YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC18B11.02c
Organism:	Schizosaccharomyces pombe
Length:	394 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC18B11.02c.

Description	E-value	Query Range	Subject Range
gi\|49645320 - gi\|49645320\|emb\|CAG98892.1\| KLLA0F24794p [Kluyveromyces lactis] gi\|50312303, gi\|... - gi\|50312303\|ref\|XP_456184.1\| unnamed protein product [Kluyveromyces lactis], gi\|49645320\|emb\|CAG9889...	303.0	[0..7]	[382..73]
gi\|44983458, gi\|... - gi\|45190516\|ref\|NP_984770.1\| AEL091Cp [Ashbya gossypii ATCC 10895], gi\|44983458\|gb\|AAS52594.1\| AEL09... gi\|44983458 - gi\|44983458\|gb\|AAS52594.1\| AEL091Cp [Ashbya gossypii ATCC 10895]	302.0	[0..12]	[382..95]
RIB2 - Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase cata... RIB2_YEAST - Bifunctional protein RIB2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RIB2 PE=1 SV=1	297.0	[0..7]	[382..62]
gi\|66519850 - gi\|66519850\|ref\|XP_624656.1\| PREDICTED: similar to RluA-1 CG31719-PA, isoform A [Apis mellifera]	296.0	[0..3]	[380..96]
gi\|221322942 - gi\|221322942\|ref\|ZP_03604236.1\| hypothetical protein BsubsS_08522 [Bacillus subtilis subsp. subtilis... gi\|221318669 - gi\|221318669\|ref\|ZP_03599963.1\| hypothetical protein BsubsJ_08416 [Bacillus subtilis subsp. subtilis... gi\|221313745 - gi\|221313745\|ref\|ZP_03595550.1\| hypothetical protein BsubsN3_08482 [Bacillus subtilis subsp. subtili... YLYB_BACSU - Uncharacterized RNA pseudouridine synthase YlyB OS=Bacillus subtilis (strain 168) GN=ylyB PE=3 SV=3 YLYB_BACSU - Uncharacterized RNA pseudouridine synthase ylyB OS=Bacillus subtilis GN=ylyB PE=3 SV=3	293.0	[0..29]	[338..1]
gi\|58391643, gi\|... - gi\|58391643\|ref\|XP_318750.2\| ENSANGP00000004675 [Anopheles gambiae str. PEST], gi\|55235872\|gb\|EAA145...	293.0	[0..3]	[380..12]
gi\|81246458, gi\|... - gi\|82545047\|ref\|YP_408994.1\| 23S rRNA pseudouridine synthase D [Shigella boydii Sb227], gi\|81246458\|... gi\|187429681, gi... - gi\|75178203\|ref\|ZP_00698262.1\| COG0564: Pseudouridylate synthases, 23S RNA-specific [Shigella boydii...	291.0	[0..31]	[360..6]
gi\|30063991, gi\|... - gi\|30063991\|ref\|NP_838162.1\| 23S rRNA pseudouridine synthase D [Shigella flexneri 2a str. 2457T], gi... gi\|73856630, gi\|... - gi\|74313153\|ref\|YP_311572.1\| 23S rRNA pseudouridine synthase D [Shigella sonnei Ss046], gi\|73856630\|... RLUD_SHIFL - Ribosomal large subunit pseudouridine synthase D OS=Shigella flexneri GN=rluD PE=3 SV=2 RLUD_ECOL6 - Ribosomal large subunit pseudouridine synthase D OS=Escherichia coli O6 GN=rluD PE=3 SV=2 gi\|24053038, gi\|... - gi\|24113932\|ref\|NP_708442.1\| 23S rRNA pseudouridine synthase D [Shigella flexneri 2a str. 301], gi\|2... RLUD_ECOL6 - Ribosomal large subunit pseudouridine synthase D OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700... gi\|218555174, gi... - gi\|218555174\|ref\|YP_002388087.1\| 23S rRNA pseudouridine synthase D [Escherichia coli IAI1], gi\|21836... gi\|218352951, gi... - gi\|218696219\|ref\|YP_002403886.1\| 23S rRNA pseudouridine synthase D [Escherichia coli 55989], gi\|2183... gi\|75236018, gi\|... - gi\|75236018\|ref\|ZP_00720152.1\| COG0564: Pseudouridylate synthases, 23S RNA-specific [Escherichia col... gi\|110344349, gi... - gi\|110642757\|ref\|YP_670487.1\| 23S rRNA pseudouridine synthase D [Escherichia coli 536], gi\|110344349... gi\|110806535, gi... - gi\|110806535\|ref\|YP_690055.1\| 23S rRNA pseudouridine synthase D [Shigella flexneri 5 str. 8401], gi\|...	291.0	[0..31]	[360..6]
gi\|193064062, gi... - gi\|75258015\|ref\|ZP_00729489.1\| COG0564: Pseudouridylate synthases, 23S RNA-specific [Escherichia col... gi\|75227673, gi\|... - gi\|75227673\|ref\|ZP_00714414.1\| COG0564: Pseudouridylate synthases, 23S RNA-specific [Escherichia col... gi\|193071695, gi... - gi\|75214714\|ref\|ZP_00713222.1\| COG0564: Pseudouridylate synthases, 23S RNA-specific [Escherichia col... gi\|75208570, gi\|... - gi\|75208570\|ref\|ZP_00708883.1\| COG0564: Pseudouridylate synthases, 23S RNA-specific [Escherichia col... gi\|209913330, gi... - gi\|209920071\|ref\|YP_002294155.1\| 23S rRNA pseudouridine synthase D [Escherichia coli SE11], gi\|20991... gi\|157078638, gi... - gi\|75187343\|ref\|ZP_00700610.1\| COG0564: Pseudouridylate synthases, 23S RNA-specific [Escherichia col...	291.0	[0..31]	[360..6]
gi\|46111497, gi\|... - gi\|46111497\|ref\|XP_382806.1\| hypothetical protein FG02630.1 [Gibberella zeae PH-1], gi\|42547066\|gb\|E...	291.0	[0..5]	[381..80]

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Predicted Domain #1

Region A:
Residues: [1-394]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKRPKRDPL KDCEYVFKGD GLRRVPPYYY EYITFAKLRW YGKTLLEVFN TEFRDRESGY  60
   61 YEKAIRNGQV KVNNQIGNVD TLIENGYIVS HHAHRHEPPV SDQPVGIVHE DESYVVIDKP 120
  121 AGVPVHPTGR YNHNTVLHIL MKENKCSLLY PCNRLDRLTS GLMFFSKSPK AAEEMRVHMI 180
  181 SKSLKKEYVA RVIGEFPNSG EVICDAPLLT VAPTLGLNRI HPDGKEASTV FKRIAFDGHT 240
  241 SLVLCKPLTG RTHQLRVHLQ YLGYPIANDP IYANKRVWGP SLGKNGEGSN ESVIMRLSEI 300
  301 GKTETASPLL QYEWYTNETE AEAKARRDKR LGELLTGKHC SECGTPLYSD PSPEELGIWL 360
  361 HALKYESKDW SYKTQLPKWA LDVCCRDPNA LPIE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.09691
Match:	1qyuA
Description:	Structure of the catalytic domain of 23S rRNA pseudouridine synthase RluD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pseudouridine synthase activity	5.19957135839682	bayes_pls_golite062009
intramolecular transferase activity	3.78688422405974	bayes_pls_golite062009
isomerase activity	2.91720316078381	bayes_pls_golite062009
catalytic activity	2.02180970970004	bayes_pls_golite062009
transcription regulator activity	1.21173188039059	bayes_pls_golite062009
DNA binding	0.950713703876672	bayes_pls_golite062009
nucleic acid binding	0.909704702595901	bayes_pls_golite062009
binding	0.730744558777463	bayes_pls_golite062009
RNA binding	0.706879359688019	bayes_pls_golite062009
transferase activity	0.237728328252954	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: