YRC Public Data Repository - Protein Structure Prediction

Protein:	trp2
Organism:	Schizosaccharomyces pombe
Length:	697 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trp2.

Description	E-value	Query Range	Subject Range
TRP_NEUCR - Tryptophan synthase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / F... TRP_NEUCR - Tryptophan synthase OS=Neurospora crassa GN=trp-3 PE=1 SV=1	757.0	[0..2]	[697..1]
gi\|28800025 - gi\|28800025\|gb\|AAO47003.1\| tryptophan synthetase [Nodulisporium sp. ATCC74245]	752.0	[0..2]	[697..1]
gi\|238881278 - gi\|238881278\|gb\|EEQ44916.1\| tryptophan synthase [Candida albicans WO-1] gi\|46431495, gi\|... - gi\|68491800\|ref\|XP_710312.1\| likely tryptophan synthetase alpha chain [Candida albicans SC5314], gi\|... orf19.4718 - TRP5 CGDID:CAL0004378 Assembly 19, Contig19-2212 (10836, 12944) CDS, translated using codon table 12...	749.0	[0..1]	[697..1]
TRP_YEAST - Tryptophan synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRP5 PE=1 SV=1 TRP5 - Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general co...	744.0	[0..1]	[697..1]
gi\|46138457, gi\|... - gi\|46138457\|ref\|XP_390919.1\| TRP_NEUCR Tryptophan synthase [Gibberella zeae PH-1], gi\|42552157\|gb\|EA...	742.0	[0..2]	[697..1]
gi\|115384238, gi... - gi\|115384238\|ref\|XP_001208666.1\| tryptophan synthase [Aspergillus terreus NIH2624], gi\|114196358\|gb\|...	740.0	[0..2]	[697..1]
gi\|49097816, gi\|... - gi\|67540122\|ref\|XP_663835.1\| hypothetical protein AN6231.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	740.0	[0..2]	[697..1]
gi\|49524131 - gi\|49524131\|emb\|CAG57722.1\| unnamed protein product [Candida glabrata] gi\|50284803, gi\|... - gi\|50284803\|ref\|XP_444829.1\| hypothetical protein CAGL0A01430g [Candida glabrata CBS138], gi\|4952413...	735.0	[0..1]	[697..1]
gi\|119190055, gi... - gi\|90304420\|gb\|EAS34051.1\| hypothetical protein CIMG_05075 [Coccidioides immitis RS], gi\|119190055\|r...	733.0	[0..2]	[697..1]
gi\|50420927, gi\|... - gi\|50420927\|ref\|XP_459006.1\| hypothetical protein DEHA0D13552g [Debaryomyces hansenii CBS767], gi\|49...	732.0	[0..1]	[697..1]

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Predicted Domain #1

Region A:
Residues: [1-265]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEQIKKTFL KAKEENKNVL VTFVTCGFPN VDETIKIMQG LQNGGAGIIE LGIPFSDAVA  60
   61 DGPTICKGNE IALKNNITLE KVFETVKLAR DAGVTIPIIL MGYYNPIFSY GDAKTIQKAK 120
  121 EVGANGFIIV DLPPEEAVGF REECKKQGVS FVPLVAPSTT DRRMELLASV ADSFIYVVSR 180
  181 MGSTGSSATG VINTALPQLC QRVRKFAGDT PLAVGFGVNT SEHFHQVGSV SDGVVVGSKI 240
  241 IDLILKAEPG TAATVVEEYC KYLTK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.522879
Match:	2ekcA
Description:	No description for 2ekcA was found.

Predicted Domain #2

Region A:
Residues: [266-697]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDPSAPVPKQ FQSGGSVATA PPAAVVEPIN EMYLPQKYGM FGGMYVPEAL TQCLVELESV  60
   61 FYKALHDEKF WEEFRSYYEY MGRPSALDYA KRLTEYCGGA HIWLKREDLN HGGSHKINNC 120
  121 IGQILLAKRL GKNRIIAETG AGQHGVATAI CAAKFGMKCT IYMGAEDCRR QALNVFRIRL 180
  181 LGAEVVPVTS GTQTLRDAVN EALKAWVEQI DTTHYLIGSA IGPHPFPTIV KTFQSVIGEE 240
  241 TKAQMQEKRK KLPDAVVACV GGGSNSIGMF SPFKADKSVM MLGCEAGGDG VDTPKHSATL 300
  301 TMGKVGVFHG VRTYVLQRED GQIQDTHSIS AGLDYPGVGP ELSELKYTNR AEFIAVTDAQ 360
  361 CLEGFRALCH LEGIIPALES SHAVYGGMEL AKKLPKDKDI VITISGRGDK DVQSVAEQLP 420
  421 ILGPKIGWDL RF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	122.0
Match:	1v8zA
Description:	X-ray crystal structure of the Tryptophan Synthase b2 Subunit from Hyperthermophile, Pyrococcus furiosus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
tryptophan synthase activity	3.62092042588636	bayes_pls_golite062009
catalytic activity	2.38994231321972	bayes_pls_golite062009
lyase activity	1.87743897464083	bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates	1.42195744285403	bayes_pls_golite062009
binding	1.34539784687114	bayes_pls_golite062009
cysteine synthase activity	1.31641967296632	bayes_pls_golite062009
carbon-oxygen lyase activity	0.923824749425553	bayes_pls_golite062009
threonine synthase activity	0.727838845253199	bayes_pls_golite062009
ammonia-lyase activity	0.476674617721478	bayes_pls_golite062009
L-threonine ammonia-lyase activity	0.37325071016009	bayes_pls_golite062009
carbon-nitrogen lyase activity	0.249761226675912	bayes_pls_golite062009
protein binding	0.044015703839169	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: