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View Structure Prediction Details

Protein: tpp1
Organism: Schizosaccharomyces pombe
Length: 817 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tpp1.

Description E-value Query
Range
Subject
Range
gi|60265773, gi|... - gi|60265773|gb|AAX16015.1| trehalose-6-phosphate synthase [Ginkgo biloba], gi|60265771|gb|AAX16014.1...
536.0 [0..1] [817..31]
gi|19568935 - gi|19568935|gb|AAL91978.1|AF483209_1 putative trehalose synthase [Solanum tuberosum]
527.0 [0..1] [817..33]
gi|215695376, gi... - gi|57899511|dbj|BAD86973.1| putative trehalose-6-phosphate synthase/phosphatase [Oryza sativa Japoni...
519.0 [0..1] [816..44]
TPS7_ARATH - Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 7 OS=Arabidopsis thaliana GN=TPS7 PE...
517.0 [0..1] [816..31]
gi|39942722, gi|... - gi|39942722|ref|XP_360898.1| hypothetical protein MG03441.4 [Magnaporthe grisea 70-15], gb|EAA51846....
512.0 [0..16] [817..315]
gi|42554455, gi|... - gi|46127097|ref|XP_388102.1| hypothetical protein FG07926.1 [Gibberella zeae PH-1], gi|42554455|gb|E...
508.0 [0..19] [817..6]

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Predicted Domain #1
Region A:
Residues: [1-93]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVYGKIPST SFEHENTFEL SGDLLDPEEL KSLGVSGRII YVLRHLPFKS SINEETREWD  60
   61 LSGRRGATTM YSSMNWLANS TYWQTTLVGW TGV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [94-549]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPTVSEKEEN KDAVTRLDSQ DVKRFEETYS QWNSGERSTE YVPVWLPGPE KGSETIINET  60
   61 RSQQSRWLAY AENVIRPLIH YKYWPSSEVD ENEEQWWRDY VKMNHAFADK ICEIYKPGDF 120
  121 IIVQDYSLFL VPQLIRNKID DAVIGFYHHH PFPSSEIARC FPRRRAILRS VLGADFIGFE 180
  181 DYSYARHFIS CCSRVLDLEI GHDWVNLNGN KVTVRAITVG IDVPRIIRSS GNVSVSEKLE 240
  241 ELNKRYENMK VILGRDRLDE LYGVPQKLRS FQRFLRTYPE WRKKVVLIQI TISSAFKHPK 300
  301 LLSSIKKLVQ AINQEFGTDD YTPVHHVEEQ LEPADYFALL TRADALFINS IREGVSNLAL 360
  361 EYVVCQRDRY GMVLLSEFTA TSAMLHDVPL INPWDYNECA EIISNALSTP LERRKMIERE 420
  421 SYKQVTTHTM QSWTSSLIRS LANKLAATKT DQRIPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.39794
Match: 1uqtA
Description: Trehalose-6-phosphate from E. coli bound with UDP-2-fluoro glucose.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 11.2045941324603 bayes_pls_golite062009
glucosyltransferase activity 8.25064561355471 bayes_pls_golite062009
UDP-glucosyltransferase activity 8.0463972704113 bayes_pls_golite062009
trehalose-phosphatase activity 7.58500038184065 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 3.70184884300914 bayes_pls_golite062009
catalytic activity 2.65148466065976 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.62403914335522 bayes_pls_golite062009
transferase activity 2.18054407163329 bayes_pls_golite062009
UDP-glycosyltransferase activity 2.13085705769565 bayes_pls_golite062009
binding 0.86799881302731 bayes_pls_golite062009
carbohydrate phosphatase activity 0.78952375993773 bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity 0.690032302126686 bayes_pls_golite062009
glycogen phosphorylase activity 0.607220464589157 bayes_pls_golite062009
phosphorylase activity 0.296436712681472 bayes_pls_golite062009
mannosyltransferase activity 0.253888301381021 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [550-817]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPEHALSVY SKASKRLFMM DYDGTLTPIV RDPNAAVPSK KLLDNLATLA ADPKNQVWII  60
   61 SGRDQQFLRN WMDDIKGLGL SAEHGSFVRK PHSTTWINLA ELLDMSWKKE VRRIFQYYTD 120
  121 RTQGSSIEEK RCAMTWHYRK ADPENGAFQA LECEALLEEL VCSKYDVEIM RGKANLEVRP 180
  181 SSINKGGIVK QILSSYPEDS LPSFIFCAGD DRTDEDMFRS LHKNTRINKE TSFAVTIGSD 240
  241 KKLSIADWCI ADPANVIDIL ADLANFTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 1rkqA
Description: Crystal structure of NYSGRC target T1436: A Hypothetical protein yidA.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
trehalose-phosphatase activity 3.78859922218487 bayes_pls_golite062009
catalytic activity 1.55296860681783 bayes_pls_golite062009
binding 0.54369553186176 bayes_pls_golite062009
hydrolase activity 0.385402333062566 bayes_pls_golite062009
nucleic acid binding 0.263520144636139 bayes_pls_golite062009
phosphatase activity 0.159899259988948 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.103902756538853 bayes_pls_golite062009
DNA binding 0.0142681844140111 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle