YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC8D2.18c
Organism:	Schizosaccharomyces pombe
Length:	433 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC8D2.18c.

Description	E-value	Query Range	Subject Range
gi\|91083583 - gi\|91083583\|ref\|XP_968366.1\| PREDICTED: similar to adenosylhomocysteinase [Tribolium castaneum]	570.0	[0..1]	[433..1]
gi\|138519669, gi... - gi\|89269565\|emb\|CAJ82626.1\| S-adenosylhomocysteine hydrolase [Xenopus tropicalis], gi\|138519669\|gb\|A...	564.0	[0..6]	[433..7]
gi\|54297948, gi\|... - gi\|54297948\|ref\|YP_124317.1\| S-adenosyl-L-homocysteine hydrolase [Legionella pneumophila str. Paris]...	564.0	[0..4]	[433..15]
gi\|54294919, gi\|... - gi\|54294919\|ref\|YP_127334.1\| S-adenosyl-L-homocysteine hydrolase [Legionella pneumophila str. Lens],...	562.0	[0..4]	[433..15]
FBpp0312000, Ahc... - The gene Adenosylhomocysteinase at 13 is referred to in FlyBase by the symbol Dmel\Ahcy13 (CG11654, ...	562.0	[0..1]	[433..1]
gi\|40363541, gi\|... - gi\|40363541\|ref\|NP_954688.1\| S-adenosylhomocysteine hydrolase [Danio rerio], gi\|37681725\|gb\|AAQ97740...	561.0	[0..6]	[433..7]
gi\|52842238, gi\|... - gi\|52842238\|ref\|YP_096037.1\| S-adenosyl-L-homocysteine hydrolase [Legionella pneumophila subsp. pneu...	561.0	[0..4]	[433..15]
SAHHA_XENLA - Adenosylhomocysteinase A OS=Xenopus laevis GN=ahcy-a PE=2 SV=1	560.0	[0..6]	[433..7]

Back

Predicted Domain #1

Region A:
Residues: [1-433]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATQNYKVAD ISLAAFGRKE LEIAENEMPG LIAVREKYAK SQPLKGARIA GCLHMTIQTA  60
   61 VLIETLVALG AEVTWSSCNI YSTQDHAAAA IAATGVPVFA WKGETEEEYL WCIEQQLKSF 120
  121 PSGKPLNMIL DDGGDLTALV HERHPELLVD IRGISEETTT GVHNLYKMFK ENKLKVPAIN 180
  181 VNDSVTKSKF DNLFGCKESL VDGIKRATDV MIAGKVAVVA GFGDVGKGCS TSLRSQGARV 240
  241 IVTEVDPINA LQAAMDGFEV TTMEEAVKEG QIFVTTTGCR DIIRGEHFNE MKEDSIVCNI 300
  301 GHFDVEIDVA WLKANAKDVV NIKPQVDRYE LKNGRHIILL ADGRLVNLGC ATGHPSFVMS 360
  361 CSFTNQVLAQ IALWTDNTSY PLGVHMLPKK LDEEVARLHL GKLGVKLTTL TSVQSDYLGI 420
  421 PVDGPYKADH YRY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	156.0
Match:	1xwfA
Description:	K185N mutated S-adenosylhomocysteine hydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
adenosylhomocysteinase activity	4.75102111339352	bayes_pls_golite062009
trialkylsulfonium hydrolase activity	4.75102111339352	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity	0.9367410227151	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009
DNA binding	0.158019531459925	bayes_pls_golite062009
nucleic acid binding	0.0191997392158629	bayes_pls_golite062009
transcription regulator activity	0.012678711735872	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: