YRC Public Data Repository - Protein Structure Prediction

Protein:	ura2
Organism:	Schizosaccharomyces pombe
Length:	337 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ura2.

Description	E-value	Query Range	Subject Range
PYRC_STAEQ - Dihydroorotase OS=Staphylococcus epidermidis (strain ATCC 35984 / RP62A) GN=pyrC PE=3 SV=1 gi\|242234057, gi... - gi\|242242483\|ref\|ZP_04796928.1\| dihydroorotase [Staphylococcus epidermidis W23144], gi\|242234057\|gb\|...	309.0	[0..2]	[333..49]
PYRC_STAEP - (Q8CPJ6) Dihydroorotase (EC 3.5.2.3) (DHOase) PYRC_STAES - Dihydroorotase OS=Staphylococcus epidermidis (strain ATCC 12228) GN=pyrC PE=3 SV=1	306.0	[0..2]	[333..49]
gi\|195991527, gi... - gi\|196035878\|ref\|ZP_03103280.1\| dihydroorotase [Bacillus cereus W], gi\|195991527\|gb\|EDX55493.1\| dihy... gi\|190565763, gi... - gi\|190565763\|ref\|ZP_03018682.1\| dihydroorotase [Bacillus anthracis Tsiankovskii-I], gi\|190562682\|gb\|... PYRC_BACC0 - Dihydroorotase OS=Bacillus cereus (strain AH820) GN=pyrC PE=3 SV=1 gi\|30263891, gi\|... - gi\|30263891\|ref\|NP_846268.1\| dihydroorotase [Bacillus anthracis str. Ames], gi\|30258535\|gb\|AAP27754.... gi\|21401873, gi\|... - gi\|65321216\|ref\|ZP_00394175.1\| COG0044: Dihydroorotase and related cyclic amidohydrolases [Bacillus ... PYRC_BACAC - Dihydroorotase OS=Bacillus anthracis (strain CDC 684 / NRRL 3495) GN=pyrC PE=3 SV=1 PYRC_BACAA - Dihydroorotase OS=Bacillus anthracis (strain A0248) GN=pyrC PE=3 SV=1 gi\|254721421 - gi\|254721421\|ref\|ZP_05183210.1\| dihydroorotase [Bacillus anthracis str. A1055] gi\|167510936, gi... - gi\|167641156\|ref\|ZP_02399411.1\| dihydroorotase [Bacillus anthracis str. A0193], gi\|167510936\|gb\|EDR8... gi\|254735928 - gi\|254735928\|ref\|ZP_05193634.1\| dihydroorotase [Bacillus anthracis str. Western North America USA615... gi\|165872277, gi... - gi\|165872277\|ref\|ZP_02216914.1\| dihydroorotase [Bacillus anthracis str. A0488], gi\|164711953\|gb\|EDR1... gi\|254751014 - gi\|254751014\|ref\|ZP_05203053.1\| dihydroorotase [Bacillus anthracis str. Vollum] gi\|49186738, gi\|... - gi\|49186738\|ref\|YP_029990.1\| dihydroorotase [Bacillus anthracis str. Sterne], gi\|49180665\|gb\|AAT5604... gi\|172080423, gi... - gi\|177654912\|ref\|ZP_02936629.1\| dihydroorotase [Bacillus anthracis str. A0174], gi\|172080423\|gb\|EDT6... gi\|254756679 - gi\|254756679\|ref\|ZP_05208708.1\| dihydroorotase [Bacillus anthracis str. Australia 94] gi\|47504468, gi\|... - gi\|47529320\|ref\|YP_020669.1\| dihydroorotase [Bacillus anthracis str. 'Ames Ancestor'], gi\|47504468\|g... gi\|170126290, gi... - gi\|170708805\|ref\|ZP_02899241.1\| dihydroorotase [Bacillus anthracis str. A0389], gi\|170126290\|gb\|EDS9... PYRC_BACAN - Dihydroorotase OS=Bacillus anthracis GN=pyrC PE=1 SV=1	304.0	[0..3]	[334..50]
gi\|89098723, gi\|... - gi\|89098723\|ref\|ZP_01171605.1\| dihydroorotase [Bacillus sp. NRRL B-14911], gi\|89086685\|gb\|EAR65804.1...	303.0	[0..3]	[334..50]
PYRC_BACHK - Dihydroorotase OS=Bacillus thuringiensis subsp. konkukian GN=pyrC PE=3 SV=1 PYRC_BACHK - Dihydroorotase OS=Bacillus thuringiensis subsp. konkukian (strain 97-27) GN=pyrC PE=3 SV=1	302.0	[0..3]	[334..50]
gi\|196047421, gi... - gi\|196047421\|ref\|ZP_03114633.1\| dihydroorotase [Bacillus cereus 03BB108], gi\|196021729\|gb\|EDX60424.1... PYRC_BACAH - Dihydroorotase OS=Bacillus thuringiensis (strain Al Hakam) GN=pyrC PE=3 SV=1 gi\|47553845, gi\|... - gi\|47569516\|ref\|ZP_00240196.1\| dihydroorotase [Bacillus cereus G9241], gi\|47553845\|gb\|EAL12216.1\| di... PYRC_BACCZ - Dihydroorotase OS=Bacillus cereus (strain ZK / E33L) GN=pyrC PE=3 SV=1 gi\|196030339, gi... - gi\|196038616\|ref\|ZP_03105924.1\| dihydroorotase [Bacillus cereus NVH0597-99], gi\|196030339\|gb\|EDX6893...	302.0	[0..3]	[334..50]
PYRC_BACCL - Dihydroorotase OS=Bacillus caldolyticus GN=pyrC PE=3 SV=1	301.0	[0..3]	[334..51]
PYRC_GEOKA - Dihydroorotase OS=Geobacillus kaustophilus (strain HTA426) GN=pyrC PE=3 SV=1 PYRC_GEOKA - Dihydroorotase OS=Geobacillus kaustophilus GN=pyrC PE=3 SV=1	301.0	[0..3]	[334..52]
PYRC_BACLD - Dihydroorotase OS=Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB...	301.0	[0..4]	[333..51]
PYRC_BACC1 - Dihydroorotase OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=pyrC PE=3 SV=1	301.0	[0..3]	[334..50]

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Predicted Domain #1

Region A:
Residues: [1-337]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKIPGLAD MHVHLRQDNM LKAVVPTVAE GGVSVAYVMP NLIPPITTVD ACLQYKKEIE  60
   61 QLDSKTTYLM SLYLSPETTP EVIYEAAKKG IRGVKSYPKG ATTNSESGVE SYEPFYPTFA 120
  121 AMQETGMILN IHGEVPPSKD NTVFTAEPKF LPTLLDLHQR FPKLKIVLEH CTTADAVEAV 180
  181 KACGESVAGT ITAHHLYLTQ KDWQDDPYCF CKPVAKTERD RRALIEAATS KNPKFFFGSD 240
  241 SAPHPRSSKL KTPPAAGVFT QPFAASYLAE VFDKEGRLDA LKDFACIFGR KFYCIPLDFK 300
  301 ESNIVLKKES FRVPESVAND LVPFHPNEVL QWHCSWE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.045757
Match:	1xgeA
Description:	Dihydroorotase from Escherichia coli: Loop Movement and Cooperativity between subunits
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydroorotase activity	2.32070383330692	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	2.20489529944693	bayes_pls_golite062009
deaminase activity	1.79186203771221	bayes_pls_golite062009
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.60895003474033	bayes_pls_golite062009
nucleic acid binding	0.629962267754185	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.573107361273483	bayes_pls_golite062009
transcription regulator activity	0.506159010274668	bayes_pls_golite062009
DNA binding	0.462348875991261	bayes_pls_golite062009
binding	0.459041534336076	bayes_pls_golite062009
hydrolase activity	0.24275130580417	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: