YRC Public Data Repository - Protein Structure Prediction

Protein:	ade6
Organism:	Schizosaccharomyces pombe
Length:	552 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ade6.

Description	E-value	Query Range	Subject Range
gi\|1813614 - gi\|1813614\|gb\|AAC49742.1\| phosphoribosylaminoimidazole carboxylase [Candida albicans]	419.0	[0..3]	[551..2]
PUR6_CANAL - Phosphoribosylaminoimidazole carboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE2... sp\|Q92210\|PUR6_C... - ADE2 CGDID:CAL0003241 Assembly 19, Contig19-10236 (89577, 87871) CDS, reverse complemented, translat...	419.0	[0..3]	[551..2]
PUR6_CANGA - Phosphoribosylaminoimidazole carboxylase OS=Candida glabrata GN=ADE2 PE=3 SV=2 PUR6_CANGA - Phosphoribosylaminoimidazole carboxylase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 ...	418.0	[0..3]	[551..2]
PUR6_SCHOC - Phosphoribosylaminoimidazole carboxylase OS=Schwanniomyces occidentalis GN=ADE2 PE=3 SV=1	416.0	[0..3]	[550..2]
gi\|3342244 - gi\|3342244\|gb\|AAC27548.1\| aminoimidazole ribonucleotide carboxylase [Candida glabrata]	414.0	[0..3]	[551..2]
gi\|31580804 - gi\|31580804\|gb\|AAP51419.1\| chimeric p53-yADE2 [Yeast truncation assay backbone vector pLSK870]	410.0	[0..3]	[551..15]
gi\|151945749 - gi\|151945749\|gb\|EDN63990.1\| phosphoribosylaminoimidazole carboxylase [Saccharomyces cerevisiae YJM78... gi\|195972362 - gi\|195972362\|gb\|ACG61339.1\| ADE-1 [Expression vector pYAA-ZP-MCS] gi\|3243009 - gi\|3243009\|gb\|AAC23867.1\| phosphoribosylaminoimidazole carboxylase [Expression vector pBEVY-A] gi\|3243012 - gi\|3243012\|gb\|AAC23869.1\| phosphoribosylaminoimidazole carboxylase [Expression vector pBEVY-GA] gi\|3243116 - gi\|3243116\|gb\|AAC40224.1\| phosphoribosylamino-imidazole-carboxylase [Integrating expression vector Y... gi\|38327510 - gi\|38327510\|gb\|AAR17787.1\| phosphoribosylamino-imidazole-carboxylase [Cloning vector pPGA89] PUR6_YEAST - Phosphoribosylaminoimidazole carboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... ADE2 - Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosyn...	409.0	[0..3]	[551..2]
gi\|6018748, gi\|1... - gi\|6018748\|emb\|CAB57994.1\| phosphoribosylaminoimidazole carboxylase [Zygosaccharomyces rouxii], gi\|2... gi\|254585243 - gi\|254585243\|ref\|XP_002498189.1\| ZYRO0G04400p [Zygosaccharomyces rouxii] gi\|146189516 - gi\|146189516\|emb\|CAM91751.1\| phosphoribosylaminoimidazole carboxylase [Cloning vector pZCAA] gi\|146189499 - gi\|146189499\|emb\|CAM91225.1\| phosphoribosylaminoimidazole carboxylase [Cloning vector pZEA]	405.0	[0..3]	[551..2]
gi\|18482492 - gi\|18482492\|gb\|AAL68881.1\| phosphoribosylaminoimidazole carboxylase [Dipodascus magnusii]	397.0	[0..3]	[551..2]

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Predicted Domain #1

Region A:
Residues: [1-394]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKQVVGIL GGGQLGRMMV EAAHRLNIKC IILDAANSPA KQIDGGREHI DASFTDPDAI  60
   61 VELSKKCTLL TTEIEHINTD ALAAVTKSVA VEPSPATLRC IQDKYLQKQH LQVFKIALPE 120
  121 FCDAPDQESV EKAGQEFGYP FVLKSKTLAY DGRGNYVVHQ PSEIPTAIKA LGDRPLYVEK 180
  181 FVPFSMEIAV MVVRSLDGKV YAYPTTETIQ KDNVCHLVYA PARLPFSIQQ RAQTLAMDAV 240
  241 RTFEGAGIYG VEMFVLQDGE TILLNEIAPR PHNSGHYTIE ACPTSQFEAH LRAICGLPFS 300
  301 EINTQLSTST THALMVNILG TDDPDYVSKI AKRSLSIPGA TLHLYGKAES RKGRKMGHVT 360
  361 IISDSPQECE RRYQMLLDVK DPVESPVVGI IMGS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.0
Match:	2czgA
Description:	Crystal structure of Probable phosphoribosylglycinamide formyl transferase (PH0318) from Pyrococcus horikoshii OT3
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [395-552]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSDLSKMKDA AVILDEFKVP YELTIVSAHR TPDRMVTYAR TAASRGLRVI IAGAGGAAHL  60
   61 PGMVAAMTPL PVIGVPVKGS TLDGVDSLHS IVQMPRGVPV ATVAINNSQN AGILACRILA 120
  121 TFQPSLLAAM ESFMDNMKEI VLEKADKLEK VGWKNYSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.69897
Match:	1o4vA
Description:	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoribosylaminoimidazole carboxylase activity	12.126616405613	bayes_pls_golite062009
carboxy-lyase activity	8.23768576957333	bayes_pls_golite062009
carbon-carbon lyase activity	2.36590642968819	bayes_pls_golite062009
catalytic activity	1.94758748334979	bayes_pls_golite062009
lyase activity	0.685887227538264	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: