YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC70.03c
Organism:	Schizosaccharomyces pombe
Length:	492 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC70.03c.

Description	E-value	Query Range	Subject Range
gi\|37525880, gi\|... - gi\|37525880\|ref\|NP_929224.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline...	471.0	[0..1]	[491..148]
gi\|105894673, gi... - gi\|107024484\|ref\|YP_622811.1\| delta-1-pyrroline-5-carboxylate dehydrogenase [Burkholderia cenocepaci... gi\|67662181, gi\|... - gi\|67662181\|ref\|ZP_00459471.1\| delta-1-pyrroline-5-carboxylate dehydrogenase 3 [Burkholderia cenocep...	460.0	[0..1]	[491..182]
gi\|91689678, gi\|... - gi\|91785724\|ref\|YP_560930.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline...	459.0	[0..1]	[491..145]
gi\|238723597, gi... - gi\|77975687\|ref\|ZP_00831221.1\| COG4230: Delta 1-pyrroline-5-carboxylate dehydrogenase [Yersinia fred...	459.0	[0..1]	[491..149]
gi\|149366203, gi... - gi\|149366203\|ref\|ZP_01888238.1\| multifunctional proline dehydrogenase/delta-1-pyrroline-5-carboxylat... gi\|229897964, gi... - gi\|229897964\|ref\|ZP_04513115.1\| Transcriptional repressor of PutA and PutP /Proline dehydrogenase (P... gi\|108807225, gi... - gi\|108807225\|ref\|YP_651141.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrrolin... gi\|89105425, gi\|... - gi\|89105425\|ref\|ZP_01177944.1\| COG4230: Delta 1-pyrroline-5-carboxylate dehydrogenase [Yersinia pest... gi\|25284839 - pir\|\|AH0225 1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) [imported] - Yersinia pestis (stra... gi\|165926003, gi... - gi\|165926003\|ref\|ZP_02221835.1\| bifunctional PutA protein [Yersinia pestis biovar Orientalis str. F1... gi\|167049507, gi... - gi\|167401118\|ref\|ZP_02306621.1\| bifunctional PutA protein [Yersinia pestis biovar Antiqua str. UG05-... gi\|15979873, gi\|... - gi\|218928970\|ref\|YP_002346845.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrro... gi\|165990138, gi... - gi\|166010794\|ref\|ZP_02231692.1\| bifunctional PutA protein [Yersinia pestis biovar Antiqua str. E1979... gi\|166961838, gi... - gi\|167420143\|ref\|ZP_02311896.1\| bifunctional PutA protein [Yersinia pestis biovar Orientalis str. MG...	458.0	[0..1]	[491..149]
Q66BP8\|Q66BP8_YERPS - Bifunctional PutA protein [includes: proline dehydrogenase an... - Yersinia pseudotuberculosis gi\|161511405 - gi\|161511405\|ref\|NP_992900.2\| trifunctional transcriptional regulator/proline dehydrogenase/pyrrolin... gi\|162418609, gi... - gi\|77635973\|ref\|ZP_00798051.1\| COG4230: Delta 1-pyrroline-5-carboxylate dehydrogenase [Yersinia pest... gi\|77628920, gi\|... - gi\|77628920\|ref\|ZP_00791506.1\| COG4230: Delta 1-pyrroline-5-carboxylate dehydrogenase [Yersinia pseu... gi\|166211180, gi... - gi\|166211180\|ref\|ZP_02237215.1\| bifunctional PutA protein [Yersinia pestis biovar Antiqua str. B4200... gi\|51596058, gi\|... - gi\|51596058\|ref\|YP_070249.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline... gi\|186895166, gi... - gi\|186895166\|ref\|YP_001872278.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrro... gi\|21959320, gi\|... - gi\|22126338\|ref\|NP_669761.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline... gi\|108776081, gi... - gi\|229902805\|ref\|ZP_04517922.1\| Transcriptional repressor of PutA and PutP /Proline dehydrogenase (P...	458.0	[0..1]	[491..149]
gi\|45436221, gi\|... - gi\|45441361\|ref\|NP_992900.1\| bifunctional PutA protein [includes: proline dehydrogenase and delta-1-... gi\|167055208, gi... - gi\|167425809\|ref\|ZP_02317562.1\| bifunctional PutA protein [Yersinia pestis biovar Mediaevalis str. K...	458.0	[0..1]	[491..144]
gi\|46312639, gi\|... - gi\|78064771\|ref\|YP_367540.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline...	458.0	[0..1]	[491..145]
gi\|71737353, gi\|... - gi\|71737353\|ref\|YP_272798.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline...	458.0	[0..1]	[491..146]
gi\|26991625, gi\|... - gi\|26991625\|ref\|NP_747050.1\| trifunctional transcriptional regulator/proline dehydrogenase/pyrroline...	457.0	[0..1]	[491..146]

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Predicted Domain #1

Region A:
Residues: [1-492]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRAFRLASGV LRNRKVILGI GAGSLITAGN IKIRNDSKFD AFFAKGFPDE LQHRSLFSVL  60
   61 RSAFVYEICS RAWLVKLSLG AMSLCDVFHL SFLYNPFCRY TFYKHFCGGE TPQAVMATMD 120
  121 TLQAAGITSC LNYSREVDLD GDMDVNKIAS QGVVPPQVPV PSEKNQKVLR QIADKAFESN 180
  181 MHIIDMATYK PGTVCAVKLT PFINPLVLQR YNSILNQYPV ESACNYLEHL KSPELSTYEV 240
  241 SELKKFWEYA DKLCQFAKEK QIPLFIDAEQ TYFQDCMHAV TVDLMRKYNK EVAIVHNTYQ 300
  301 LYLKKSRKIM DDHIKKCVAE GWLMGAKLVR GAYLNSEPRF LIHDTKAETD KDFDSAVEAI 360
  361 IAAAAKFAPG DPASASDPIA SRKGKWGIMV ASHNKKTMFE SVNLAETKKV DFTKTSFYLA 420
  421 QLLGMADDIT YALAYSQRNQ QPNFCIVKYV SCGPISEVLP YLVRRARENI DALDRCKEER 480
  481 AYYRQALRRR IF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	127.0
Match:	1tj2A
Description:	Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with acetate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the CH-NH group of donors	6.88732579226533	bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity	6.68550231605226	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	5.85251457886657	bayes_pls_golite062009
oxidoreductase activity	3.26500423104107	bayes_pls_golite062009
catalytic activity	2.15527229494088	bayes_pls_golite062009
methylenetetrahydrofolate reductase (NADPH) activity	1.53575450131902	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: