YRC Public Data Repository - Protein Structure Prediction

Protein:	erg12
Organism:	Schizosaccharomyces pombe
Length:	404 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for erg12.

Description	E-value	Query Range	Subject Range
gi\|32404644, gi\|... - gi\|32404644\|ref\|XP_322935.1\| hypothetical protein ( (AL513444) related to MEVALONATE KINASE [Neurosp... gi\|85102580 - gi\|85102580\|ref\|XP_961360.1\| hypothetical protein NCU03633 [Neurospora crassa OR74A]	243.0	[0..1]	[374..76]
gi\|88183104, gi\|... - gi\|88183104\|gb\|EAQ90572.1\| hypothetical protein CHGG_02507 [Chaetomium globosum CBS 148.51], gi\|1162...	241.0	[0..1]	[374..82]
gi\|83769159 - gi\|83769159\|dbj\|BAE59296.1\| unnamed protein product [Aspergillus oryzae] gi\|238491672, gi... - gi\|238491672\|ref\|XP_002377073.1\| mevalonate kinase [Aspergillus flavus NRRL3357], gi\|220697486\|gb\|EE... gi\|169773659 - gi\|169773659\|ref\|XP_001821298.1\| hypothetical protein [Aspergillus oryzae RIB40]	241.0	[0..1]	[374..86]
gi\|46123069, gi\|... - gi\|46123069\|ref\|XP_386088.1\| hypothetical protein FG05912.1 [Gibberella zeae PH-1], gi\|42552714\|gb\|E...	240.0	[0..1]	[374..57]
gi\|114192792, gi... - gi\|115398019\|ref\|XP_001214601.1\| conserved hypothetical protein [Aspergillus terreus NIH2624], gi\|11...	240.0	[0..3]	[374..94]
gi\|67526823, gi\|... - gi\|67526823\|ref\|XP_661473.1\| hypothetical protein AN3869.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	235.0	[0..3]	[374..289]
gi\|66849681, gi\|... - gi\|70994538\|ref\|XP_752047.1\| mevalonate kinase [Aspergillus fumigatus Af293], gi\|66849681\|gb\|EAL9000...	231.0	[0..1]	[374..88]
gi\|49656520 - gi\|49656520\|emb\|CAG89196.1\| DEHA2F11176p [Debaryomyces hansenii] gi\|50424525, gi\|... - gi\|50424525\|ref\|XP_460851.1\| hypothetical protein DEHA0F12188g [Debaryomyces hansenii CBS767], gi\|49...	231.0	[0..4]	[378..5]
gi\|46445332, gi\|... - gi\|68465212\|ref\|XP_723305.1\| hypothetical protein CaO19.12272 [Candida albicans SC5314], gi\|68464835... orf19.12272, orf... - orf19.4809 CGDID:CAL0005299 Assembly 19, Contig19-10215 (201746, 203041) CDS, translated using codon...	230.0	[0..4]	[378..5]
gi\|145013479, gi... - gi\|39978123\|ref\|XP_370449.1\| hypothetical protein MGG_06946 [Magnaporthe grisea 70-15], gb\|EAA55289....	229.0	[0..1]	[359..43]

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Predicted Domain #1

Region A:
Residues: [1-404]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKSLIVSSP GKTILFGEHA VVYGATALAA AVSLRSYCKL QTTNNNEIVI VMSDIGTERR  60
   61 WNLQSLPWQH VTVENVQHPA SSPNLDLLQG LGELLKNEEN GLIHSAMLCT LYLFTSLSSP 120
  121 SQGCTLTISS QVPLGAGLGS SATISVVVAT SLLLAFGNIE PPSSNSLQNN KALALIEAWS 180
  181 FLGECCIHGT PSGIDNAVAT NGGLIAFRKA TAHQSAMKEF LKPKDTLSVM ITDTKQPKST 240
  241 KKLVQGVFEL KERLPTVIDS IIDAIDGISK SAVLALTSES DKNSSAKKLG EFIVLNQKLL 300
  301 ECLGVSHYSI DRVLQATKSI GWTKLTGAGG GGCTITLLTP ECKEEEFKLC KESLLAHKNS 360
  361 IYDVQLGGPG VSVVTDSDSF FPQYESDFDF KKLNLLSKFN KYYI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.0
Match:	1kvkA
Description:	Mevalonate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.836142537655721	bayes_pls_golite062009
binding	0.769835316275102	bayes_pls_golite062009
diphosphomevalonate decarboxylase activity	0.714132174817049	bayes_pls_golite062009
carbohydrate kinase activity	0.49664490095304	bayes_pls_golite062009
nucleic acid binding	0.369771518688522	bayes_pls_golite062009
structural constituent of ribosome	0.325699575011026	bayes_pls_golite062009
transcription regulator activity	0.212099606954236	bayes_pls_golite062009
structural molecule activity	2.19428886088058E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: