YRC Public Data Repository - Protein Structure Prediction

Protein:	idp1
Organism:	Schizosaccharomyces pombe
Length:	418 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for idp1.

Description	E-value	Query Range	Subject Range
IDHP_BOVIN - (Q04467) Isocitrate dehydrogenase [NADP], mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate deca...	455.0	[0..1]	[416..31]
IDHP_MOUSE - Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus GN=Idh2 PE=1 SV=3	452.0	[0..2]	[416..32]
IDHP_RAT - Isocitrate dehydrogenase [NADP], mitochondrial OS=Rattus norvegicus GN=Idh2 PE=1 SV=2	451.0	[0..2]	[416..32]
gi\|114658862 - gi\|114658862\|ref\|XP_510589.2\| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial isoform 4...	451.0	[0..2]	[415..32]
gi\|123998944, gi... - gi\|123998944\|gb\|ABM87062.1\| isocitrate dehydrogenase 2 (NADP+), mitochondrial [synthetic construct],... IDH2 - isocitrate dehydrogenase 2 (NADP+), mitochondrial	450.0	[0..2]	[415..32]
gi\|73951496 - gi\|73951496\|ref\|XP_536192.2\| PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+), mitochondrial...	450.0	[0..10]	[416..106]
IDHP_MACFA - Isocitrate dehydrogenase [NADP], mitochondrial OS=Macaca fascicularis GN=IDH2 PE=2 SV=1 gi\|109082346 - gi\|109082346\|ref\|XP_001095686.1\| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial [Macac...	449.0	[0..2]	[415..32]

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Predicted Domain #1

Region A:
Residues: [1-418]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMRMASSKS FQKITVKNPV VEMDGDEMTR VIWKIIREKL VLPYMDIKLD YYDLGIEARD  60
   61 KTNDQITVDA AKAILKNDVG IKCATITPDE ARVKEYNLKK MWKSPNGTIR NILNGTVFRE 120
  121 PILIKNIPKY IPGWTNPICI GRHAFGDQYK STDLVASGPG KLELSFTPKG NPSAKETYNV 180
  181 YEFNGSGVAM SMYNTDDSIR GFAHSSFQMA LQKKMPLYLS TKNTILKKYD GRFKDTFQEV 240
  241 YESDYKQKFE ELGLWYQHRL IDDMVAQAIK SNGGFVWACK NYDGDVMSDV VAQAYGSLGL 300
  301 MTSVLIHPNG RTFESEAAHG TVQRHYMQYL KGKKTSTNSI ASIFAWTRGL AHRGRLDGNE 360
  361 RLVKFANALE HACVRCVEKG IMTKDLYLLS KSPNGYVDTF EFLDAVKSEL DSELVNIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.0
Match:	1lwdA
Description:	NADP-dependent isocitrate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
isocitrate dehydrogenase (NAD+) activity	5.9567768649084	bayes_pls_golite062009
isocitrate dehydrogenase activity	5.76817846591752	bayes_pls_golite062009
isocitrate dehydrogenase (NADP+) activity	3.47645456015586	bayes_pls_golite062009
oxidoreductase activity	2.74237430402883	bayes_pls_golite062009
catalytic activity	2.71251959637136	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.46799258909805	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.38235863668553	bayes_pls_golite062009
transferase activity, transferring acyl groups	1.15484868227001	bayes_pls_golite062009
3-isopropylmalate dehydrogenase activity	0.848289435089509	bayes_pls_golite062009
binding	0.530580225668688	bayes_pls_golite062009
protein binding	0.074256700284446	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: