YRC Public Data Repository - Protein Structure Prediction

Protein:	hmt2
Organism:	Schizosaccharomyces pombe
Length:	459 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hmt2.

Description	E-value	Query Range	Subject Range
gi\|82655340, gi\|... - gi\|82749809\|ref\|YP_415550.1\| sulfide-quinone reductase [Staphylococcus aureus RF122], gi\|82655340\|em...	237.0	[0..25]	[442..1]
gi\|57652429, gi\|... - gi\|57652429\|ref\|YP_184970.1\| hypothetical protein SACOL0065 [Staphylococcus aureus subsp. aureus COL... gi\|87201416, gi\|... - gi\|88193858\|ref\|YP_498643.1\| hypothetical protein SAOUHSC_00037 [Staphylococcus aureus subsp. aureus... gi\|15923078, gi\|... - gi\|15923078\|ref\|NP_370612.1\| sulfide-quinone reductase [Staphylococcus aureus subsp. aureus Mu50], g... gi\|15925792, gi\|... - gi\|15925792\|ref\|NP_373325.1\| hypothetical protein SA0084 [Staphylococcus aureus subsp. aureus N315],... gi\|21203222, gi\|... - gi\|21281787\|ref\|NP_644873.1\| hypothetical protein MW0058 [Staphylococcus aureus subsp. aureus MW2], ... gi\|49484963, gi\|... - gi\|49484963\|ref\|YP_042184.1\| putative oxidoreductase [Staphylococcus aureus subsp. aureus MSSA476], ... gi\|90429112, gi\|... - gi\|90582116\|ref\|ZP_01237881.1\| FAD-dependent pyridine nucleotide-disulphide oxidoreductase [Staphylo... gi\|148266517, gi... - gi\|90586002\|ref\|ZP_01241706.1\| FAD-dependent pyridine nucleotide-disulphide oxidoreductase [Staphylo... gi\|25506673 - pir\|\|D89768 hypothetical protein SA0084 [imported] - Staphylococcus aureus (strain N315) gi\|156720553, gi... - gi\|156978418\|ref\|YP_001440677.1\| hypothetical protein SAHV_0087 [Staphylococcus aureus subsp. aureus... gi\|253315719 - gi\|253315719\|ref\|ZP_04838932.1\| hypothetical protein SauraC_06166 [Staphylococcus aureus subsp. aure... gi\|254664016 - gi\|254664016\|ref\|ZP_05143488.1\| hypothetical protein SauraM_00420 [Staphylococcus aureus subsp. aure... gi\|269201722\|ref... - hypothetical protein SAAV_0036 [Staphylococcus aureus subsp. aureus ED98]	236.0	[0..25]	[442..1]
gi\|56420625, gi\|... - gi\|56420625\|ref\|YP_147943.1\| hypothetical protein GK2090 [Geobacillus kaustophilus HTA426], gi\|56380...	233.0	[0..30]	[442..8]
gi\|115390454, gi... - gi\|115390454\|ref\|XP_001212732.1\| conserved hypothetical protein [Aspergillus terreus NIH2624], gi\|11...	229.0	[0..5]	[442..19]
gi\|87311991, gi\|... - gi\|87311991\|ref\|ZP_01094100.1\| hypothetical protein DSM3645_04135 [Blastopirellula marina DSM 3645],...	225.0	[0..28]	[443..3]
gi\|42549863, gi\|... - gi\|46114834\|ref\|XP_383435.1\| hypothetical protein FG03259.1 [Gibberella zeae PH-1], gi\|42549863\|gb\|E...	223.0	[0..2]	[451..8]
gi\|53795841 - ref\|ZP_00356883.1\| COG0446: Uncharacterized NAD(FAD)-dependent dehydrogenases [Chloroflexus aurantia... gi\|222527420, gi... - gi\|222527420\|ref\|YP_002571891.1\| FAD-dependent pyridine nucleotide-disulphide oxidoreductase [Chloro... gi\|163670705, gi... - gi\|76257890\|ref\|ZP_00765547.1\| conserved hypothetical protein [Chloroflexus aurantiacus J-10-fl], gi...	223.0	[0..25]	[443..2]
gi\|46096746, gi\|... - gi\|71005352\|ref\|XP_757342.1\| hypothetical protein UM01195.1 [Ustilago maydis 521], ref\|XP_398810.1\| ...	223.0	[0..5]	[459..24]
gi\|67902718, gi\|... - gi\|67902718\|ref\|XP_681615.1\| hypothetical protein AN8346.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	222.0	[0..2]	[455..217]
gi\|2147325, gi\|4... - gi\|472330\|gb\|AAA21748.1\| dihydrolipoamide dehydrogenase [Clostridium magnum], pir\|\|I40794 dihydrolip...	218.0	[0..31]	[449..118]

Back

Predicted Domain #1

Region A:
Residues: [1-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTLNSTIKS VTGSFQSASM LARFASTHHK VLVVGGGSAG ISVAHQIYNK FSKYRFANDQ  60
   61 GKDTSLKPGE IGIVDGAKYH YYQPGWTLTG AGLSSVAKTR RELASLVPAD KFKLHPEFVK 120
  121 SLHPRENKIV TQSGQEISYD YLVMAAGIYT DFGRIKGLTE ALDDPNTPVV TIYSEKYADA 180
  181 VYPWIEKTKS GNAIFTQPSG VLKCAGAPQK IMWMAEDYWR RHKVRSNIDV SFYTGMPTLF 240
  241 SVKRYSDALL RQNEQLHRNV KINYKDELVE VKGSERKAVF KNLNDGSLFE RPFDLLHAVP 300
  301 SMRSHEFIAK SDLADKSGFV AVDQSTTQST KFPNVFAIGD CSGLPTSKTY AAITAQAPVM 360
  361 VHNLWSFVNG KNLTASYNGY TSCPLLTGYG KLILAEFLYK QEPKESFGRF SRFLDQTVPR 420
  421 RMFYHLKKDF FPFVYWNFAV RNGKWYGSRG LIPPHFPVN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.522879
Match:	1ebdA
Description:	Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors	2.38687908444458	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.65116166340793	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
antioxidant activity	1.49429830917872	bayes_pls_golite062009
binding	0.993436593091194	bayes_pls_golite062009
thioredoxin-disulfide reductase activity	0.844975371289313	bayes_pls_golite062009
oxidoreductase activity	0.48971304115416	bayes_pls_golite062009
peptide disulfide oxidoreductase activity	0.445102575662049	bayes_pls_golite062009
glutathione disulfide oxidoreductase activity	0.445102575662049	bayes_pls_golite062009
NADPH-adrenodoxin reductase activity	0.37585188510577	bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor	0.366059136123732	bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions	0.17657668860129	bayes_pls_golite062009
protein binding	0.116927178396589	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: