YRC Public Data Repository - Protein Structure Prediction

Protein:	his3
Organism:	Schizosaccharomyces pombe
Length:	384 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for his3.

Description	E-value	Query Range	Subject Range
AAT_AQUAE - Aspartate aminotransferase OS=Aquifex aeolicus (strain VF5) GN=aspC PE=3 SV=1 AAT_AQUAE - Aspartate aminotransferase OS=Aquifex aeolicus GN=aspC PE=3 SV=1	298.0	[0..1]	[380..20]
gi\|196253921, gi... - gi\|196253921\|ref\|ZP_03152522.1\| aminotransferase class I and II [Clostridium thermocellum DSM 4150],... gi\|67849411, gi\|... - gi\|67916633\|ref\|ZP_00510335.1\| Aminotransferase, class I and II [Clostridium thermocellum ATCC 27405...	293.0	[0..1]	[377..18]
gi\|48895332, gi\|... - gi\|71675283\|ref\|ZP_00673028.1\| Aminotransferase, class I and II [Trichodesmium erythraeum IMS101], g...	292.0	[0..1]	[378..18]
gi\|18977625, gi\|... - gi\|18977625\|ref\|NP_578982.1\| aspartate aminotransferase [Pyrococcus furiosus DSM 3638], gi\|18893347\|...	289.0	[0..8]	[379..21]
gi\|228656558, gi... - gi\|229126958\|ref\|ZP_04255969.1\| Aspartate aminotransferase [Bacillus cereus BDRD-Cer4], gi\|228656558... gi\|29895237, gi\|... - gi\|30019693\|ref\|NP_831324.1\| aspartate aminotransferase [Bacillus cereus ATCC 14579], gi\|29895237\|gb...	289.0	[0..1]	[378..18]
gi\|228859394, gi... - gi\|228900225\|ref\|ZP_04064456.1\| Aspartate aminotransferase [Bacillus thuringiensis IBL 4222], gi\|228... gi\|75760397, gi\|... - gi\|75760397\|ref\|ZP_00740441.1\| Aspartate aminotransferase [Bacillus thuringiensis serovar israelensi...	288.0	[0..1]	[378..18]
gi\|82500308, gi\|... - gi\|82500308\|ref\|ZP_00885728.1\| aspartate aminotransferase [Caldicellulosiruptor saccharolyticus DSM ...	287.0	[0..10]	[381..27]
AAT1_BACSU - Aspartate aminotransferase OS=Bacillus subtilis GN=aspB PE=3 SV=1 AAT1_BACSU - Aspartate aminotransferase OS=Bacillus subtilis (strain 168) GN=aspB PE=3 SV=1 gi\|221314475 - gi\|221314475\|ref\|ZP_03596280.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. N... gi\|221319397 - gi\|221319397\|ref\|ZP_03600691.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. J... gi\|221323673 - gi\|221323673\|ref\|ZP_03604967.1\| aspartate aminotransferase [Bacillus subtilis subsp. subtilis str. S...	286.0	[0..1]	[381..18]
gi\|28210979, gi\|... - gi\|28210979\|ref\|NP_781923.1\| aspartate aminotransferase [Clostridium tetani E88], gi\|28203418\|gb\|AAO...	286.0	[0..1]	[380..17]

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Predicted Domain #1

Region A:
Residues: [1-384]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDLNTCLRK NILELQPYRC ARDDFSEGVL LDANECAYGS VISVDGVEFN RYPDPRQIEV  60
   61 KQRLCDLRNK ELSITKPLTP DNICMGVGSD EIIDSLIRIS CIPGKDKILM CPPSYGMYTV 120
  121 SAKINDVEVV KVLLEPDFNL NVDAICETLS KDSAIKVFFA CSPGNPTAKA LKLEDIKKIL 180
  181 EHPTWNGIVV VDEAYIDFSA PDMSALTLVN EYPNLAVCQT LSKSFGLAGI RIGFCLTSKP 240
  241 IATIMNSLKA PYNISEPTSR LALDALSPQS IDKMHTYRDA IIQQRVRLCK ELTTIKGMGK 300
  301 IIGGYDANFI LIQVLDRPEG GKPSNDAAKY LYLQMATMHK VVVRFRGTEP LCEGALRITV 360
  361 GTEEENTILL KTIKLVLQEY YTKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.30103
Match:	1fg3A
Description:	Histidinol-phosphate aminotransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.29878871754893	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
histidinol-phosphate transaminase activity	1.26617748508821	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	0.81652984148807	bayes_pls_golite062009
5-aminolevulinate synthase activity	0.802089219704558	bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups	0.659071155545801	bayes_pls_golite062009
binding	0.536634592992536	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
nucleic acid binding	0.013097682076602	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: