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View Structure Prediction Details

Protein: eso1
Organism: Schizosaccharomyces pombe
Length: 872 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eso1.

Description E-value Query
Range
Subject
Range
POLK_MOUSE - DNA polymerase kappa OS=Mus musculus GN=Polk PE=1 SV=1
437.0 [0..1] [667..66]
POLK - polymerase (DNA directed) kappa
434.0 [0..1] [674..67]
gi|114599641, gi... - gi|114599641|ref|XP_001149179.1| PREDICTED: polymerase (DNA directed) kappa isoform 6 [Pan troglodyt...
431.0 [0..1] [674..67]
gi|109077621 - gi|109077621|ref|XP_001105220.1| PREDICTED: polymerase (DNA directed) kappa isoform 5 [Macaca mulatt...
423.0 [0..1] [673..67]

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Predicted Domain #1
Region A:
Residues: [1-508]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELGKSKFSW KDLQYCDKAG TQNSPLRVVA HIDQDAFYAQ VESVRLGLDH SVPLAVQQWQ  60
   61 GLIAVNYAAR AANISRHETV TEAKKKCPEL CTAHVKTWKA GESEAKYHEN PNPNYYKTCL 120
  121 DPYRHESVKI LNIIKKHAPV VKKASIDECF IELTSDVKRI VLEEYPYLKI PSEDSNVALP 180
  181 QAPVLLWPAE FGMVIEEEVV DRTKEDYERD WDDVFLFYAA KIVKEIRDDI YLQLKYTCSA 240
  241 GVSFNPMLSK LVSSRNKPNK QTILTKNAIQ DYLVSLKITD IRMLGGKFGE EIINLLGTDS 300
  301 IKDVWNMSMD FLIDKLGQTN GPLVWNLCHG IDNTEITTQV QIKSMLSAKN FSQQKVKSEE 360
  361 DAINWFQVFA SDLRSRFLEL EGMRRPKTIC LTVVSRFLRK SRSSQIPMNV DISTQFIVEA 420
  421 TSKLLRQLQQ EFDVYPISNL SISFQNIIEV DRNSRGIEGF LKKSNDEIYM STSVSPSIEG 480
  481 RAKLLNENMR ENNSFELSSE KDIKSPKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.0
Match: 1jihA
Description: DNA polymerase eta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-directed DNA polymerase activity 9.12112857204028 bayes_pls_golite062009
DNA polymerase activity 9.07163148377911 bayes_pls_golite062009
DNA primase activity 6.94812039437428 bayes_pls_golite062009
nucleotidyltransferase activity 4.75943480079119 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.94496917620645 bayes_pls_golite062009
DNA binding 2.53092801704688 bayes_pls_golite062009
nucleic acid binding 2.33765586478028 bayes_pls_golite062009
transferase activity 1.93427633579563 bayes_pls_golite062009
binding 1.83109253387887 bayes_pls_golite062009
exonuclease activity 1.68989335095363 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.60828797652808 bayes_pls_golite062009
RNA polymerase activity 1.60828797652808 bayes_pls_golite062009
damaged DNA binding 1.08077297289305 bayes_pls_golite062009
catalytic activity 1.04899053677564 bayes_pls_golite062009
chromatin binding 0.953917901573139 bayes_pls_golite062009
3'-5' exonuclease activity 0.78558451404229 bayes_pls_golite062009
structure-specific DNA binding 0.433956339585542 bayes_pls_golite062009
protein binding 0.354190470641287 bayes_pls_golite062009
nuclease activity 0.332024848299731 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.19596408995795 bayes_pls_golite062009
5'-3' exonuclease activity 0.154583332107704 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [509-703]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKRGKGKGIF DMLQQTAVSK PTENSADETY TCEECEQKIT LSERNEHEDY HIALSISRKE  60
   61 RYNNLVPPSH DKPKQVKPKT YGRKTGSKHY APLSDETNNK RAFLDAFLGN GGNLTPNWKK 120
  121 QTPKAISNSS DNMTQLHLDL ANSTVTCSEC SMEYNSTSEE DILLHSRFHS RVLGGVTVSF 180
  181 QCSPIYRVNY GLSSD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.42
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [704-872]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CIYSINSESS LIDQRKAEEA LSFVNNELSS EPIETIGVDK YTTFLFISDK KCVGLLLAER  60
   61 ISSAYIVDEL ELNNNNSTSS AVYIKNENLR KGFVLGISRI WVSASRRKQG IASLLLDNAL 120
  121 KKFIYGYVIS PAEVAFSQPS ESGKQFIISW HRSRNNGSSK SLRYAVYES

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.584 0.990 protein amino acid acetylation d.108.1 Acyl-CoA N-acyltransferases (Nat)


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle