YRC Public Data Repository - Protein Structure Prediction

Protein:	cdc45
Organism:	Schizosaccharomyces pombe
Length:	638 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cdc45.

Description	E-value	Query Range	Subject Range
gi\|4185283, gi\|6... - gi\|6753366\|ref\|NP_033992.1\| cell division cycle 45 homolog (S. cerevisiae)-like [Mus musculus], gi\|4...	739.0	[0..1]	[632..1]
gi\|64174914 - gi\|64174914\|gb\|AAY41172.1\| DNA replication protein Cdc45 [Cricetulus griseus]	738.0	[0..1]	[632..1]
gi\|3021388 - gi\|3021388\|emb\|CAA11530.1\| CDC45 like protein [Homo sapiens]	736.0	[0..1]	[632..1]
gi\|30584643, gi\|... - gi\|60653115\|gb\|AAX29252.1\| CDC45 cell division cycle 45-like [synthetic construct], gi\|60653113\|gb\|A...	735.0	[0..1]	[632..1]
gi\|114685091 - gi\|114685091\|ref\|XP_514980.2\| PREDICTED: CDC45-like [Pan troglodytes]	733.0	[0..1]	[632..1]
gi\|40882245 - gi\|40882245\|emb\|CAF06070.1\| related to sna41 protein [Neurospora crassa]	733.0	[0..1]	[638..1]
gi\|109093266 - gi\|109093266\|ref\|XP_001104872.1\| PREDICTED: similar to CDC45-like [Macaca mulatta]	730.0	[0..1]	[632..1]

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Predicted Domain #1

Region A:
Residues: [1-303]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFIKRSDYAS AYLKIKEASV SGGCTVQLFV ALDPDALCAC KLLSTLLKGD FISHKIRPVS  60
   61 GYRDLEQANK TLLEQNEDIK FIILLNCGTM VDLNNYLVSM EDVSIYVIDS HRPHNLNNIY 120
  121 IENNIFVFDD GDIEEDMNKI HDAWYAFNSH ELSDEENSDS SNEREEEVED DNRSVESYSS 180
  181 SDYQARSRRR FSEETTQRRA EIKEKRKKRK EFASILSEYY EKGSWYGESI TNILFAVASM 240
  241 LGREDNDMLW LAIVGLTCLE IHCQSSKKYF NRSYSLLKDE VNRLNPSPLE NQIVGRAHGK 300
  301 TPH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [304-428]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQSIRLEDEF RFMLVRHWSL YDSMLHSAYV GSRLHIWSEE GRKRLHKLLA KMGLSLVECK  60
   61 QTYIHMNMDL KKTLKSSLKR FAPFYGLDDV IFHSFTRTYG FKCTLSASDV SYAISALLEM 120
  121 GNTGV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.245	0.914	DNA replication initiation	a.4.5	"Winged helix" DNA-binding domain

Predicted Domain #3

Region A:
Residues: [429-638]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLQSKTVARS PDMTEEEYLE KFENAQNQEW LHNFYDAYDA LDDVDSLERA LKLAMHLQRA  60
   61 IVRTGITLLE KRAIKTLRSF RFGLINEGPD LKIFMHPLAL TKMSLWIAEA INEQEREFGK 120
  121 LRHLPLVLAA FVEEKNRYLI VGTSTSAFTS NEDDDDDDGH GHNRFGVAFQ EVANMTSATL 180
  181 QMDCFEASVI ECQKSDLGVF LESLSFKTLL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits