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View Structure Prediction Details

Protein: gi|22832460, gi|...
Organism: Drosophila melanogaster
Length: 362 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|22832460, gi|....

Description E-value Query
Range
Subject
Range
GS-PE, CG32495-P... - The gene Glutathione Synthetase is referred to in FlyBase by the symbol Dmel\GS (CG6835, FBgn0030882...
548.0 [0..14] [362..146]

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Predicted Domain #1
Region A:
Residues: [1-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWPTTRSSSR RRWRRRSKWT SSRPICSTSI ARCWRTDSPR FVLSELGHAD KLHNMPDNNA  60
   61 LAGLCDGMVK AWDIYAKPQA VILFIIEDVS YNICDQRFHE FYIRETYPHI KVLRRTLTEV 120
  121 HREGKLGQSK ELLLGSQEVA VIYFRAGYEP GHYHSQADWD ARYLMETSLA IKCPSIHYHL 180
  181 AGTKKVQQAL AQPAVLERFI NDPEEIKAVG KIFTGLYSLD DNEAGNASYE MALRTPERFV 240
  241 LKPQREGGGN NVYGVDIPDA LKRMSRVERS AWILMDLIHP PLTKGYMVRP GGDMPPQIVD 300
  301 MVSELGIFGV VIGDAEHIVH NYQAGHMLRT KLSTANEGGV AAGLGALDSP YLIDSDDEDE 360
  361 QK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 137.0
Match: 2hgsA
Description: Eukaryotic glutathione synthetase, substrate-binding domain; Eukaryotic glutathione synthetase ATP-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glutathione synthase activity 3.36797779177268 bayes_pls_golite062009
catalytic activity 2.87139587563481 bayes_pls_golite062009
ligase activity 1.70071261805297 bayes_pls_golite062009
succinate-CoA ligase activity 0.970113655642181 bayes_pls_golite062009
CoA-ligase activity 0.85407001746442 bayes_pls_golite062009
acid-thiol ligase activity 0.79517718342104 bayes_pls_golite062009
glutathione binding 0.65617009195909 bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity 0.61662787854529 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.463643664297841 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 0.45881977344533 bayes_pls_golite062009
acid-amino acid ligase activity 0.28951341378787 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle