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View Structure Prediction Details

Protein: mus101-PA
Organism: Drosophila melanogaster
Length: 1425 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mus101-PA.

Description E-value Query
Range
Subject
Range
gi|11037277 - gi|11037277|gb|AAG27544.1|AF257463_1 BRCT-domain protein MUS101 [Drosophila melanogaster]
919.0 [0..1] [1425..1]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISMSMDET ICAYFVNNLK PGDGGVQEAD TLQQFEAARE LLGQQLAETQ IRQIKPSEGY  60
   61 PLIAAGNLTK KDVFVLTQFE GEFFEQLQQT RALILGPPCL ITCLRRNEPI PEGSSAIYST 120
  121 AMRDLQVSAT GITPQKKEEL SRLINWMGGI YFQSFGHRTT HLISNTIKSS KYEQATLNGV 180
  181 PVMHVDWVQY VWDQSRRSQR EG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 2owoA
Description: No description for 2owoA was found.

Predicted Domain #2
Region A:
Residues: [203-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IMATDPDFDK YRLPIFFGAN ITCSGLDVAR KDQVMRLVND NGGIYHRAFR SQVVDIVITE  60
   61 QTKTDTEKYK AAIRYKKDVL LPEWIFDSCN RGYALPTKDY EVRPGKTSST PT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1oqaA
Description: Solution structure of the BRCT-c domain from human BRCA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.911539062312394 bayes_pls_golite062009
protein binding 0.740170908668509 bayes_pls_golite062009
catalytic activity 0.00504703671568302 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [315-483]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTTRPGAAPG ADQTHLSDLS RISFVSGSRR MCSDLSTVNE SVSSVGSSSP AKQLLKQATS  60
   61 SGRNYQQVLA EIEPRQAKKA GAFLDGCCVY LSGFRSEERE KLNRVLNTGG ATRYDEANEG 120
  121 ISHIIVGQLD DAEYRQWQRD GLMGSVHVVR LDWLLESIRA GRVVSELVH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1wf6A
Description: The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.911539062312394 bayes_pls_golite062009
protein binding 0.740170908668509 bayes_pls_golite062009
catalytic activity 0.00504703671568302 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [484-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVSMPQNREP DVASPASKRT LRSMNHSFKQ PTLPIKKKLF DQEPDPVQEQ EHEEPDHTLL  60
   61 DQYSQDQGAV AQLPPADVSL LQPAASSTQM DIRQRVSVAN PKPPAEGLQL PDLSASTLSI 120
  121 DFDKLDY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [611-709]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FAGVSVYVHR ECFNEEFFNQ MLTECEAAQG LLVPSSFSDE VDFAIVSFEV AFDVKQLPVK  60
   61 ARHVVTELFL ESCMKKNQLL PIEYYHKHVP ATALRQPLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.154902
Match: 1cdzA
Description: DNA-repair protein XRCC1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.911539062312394 bayes_pls_golite062009
protein binding 0.740170908668509 bayes_pls_golite062009
catalytic activity 0.00504703671568302 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [710-875]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMTIVVSIYA GLERDFINAT AELLGASVNK TFIKKEKPLL VCPSAEGSKY EGAIKWNYPV  60
   61 VTSDWLVQCA RTGQKLPFVG YLVGKSPEDF PISPRLRDSN SRTARRPNES TLVAQPDVTM 120
  121 EEAENQPAGS VTPVTAGSPG APELTPLRNK RVSELAGIPG GSALHR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.14
Match: 2d8mA
Description: No description for 2d8mA was found.

Predicted Domain #7
Region A:
Residues: [876-1112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSNSTSSPDS PCTPLSQVGA QQYNLDFLEQ FVQRLDTEEG KDCVREIIRE MRENQTPELE  60
   61 RIRRQACTPV SRKHQRPAPG IPDFCLTPEF QQRMADDFER RWRLPTMKIK PDTPLAVIRQ 120
  121 RVMRITCETL GIEYEESNAK TPTLSESPST VKKKPPTRTT QATKLNFDRS PKTPKLSLGK 180
  181 KTPLRVSMGS PRSGTQSPFV PNTQSPIEAA PPRRSDGPTL SEEGQSTINF DKISFEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1113-1205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAVPVLAPDV PTVAPDVKQI TDYLKNCESR RNSLKRSHDN DMDCGESEVQ YVQPFESEGF  60
   61 ALGTEDMVDW RDPAEFNAAK RRSSGGSPKM QYA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1206-1425]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIPCFSISCG DDDEKRAELI ARITQLGGKV CENLVNYDDS CTHLLCERPN RGEKMLACIA  60
   61 AGKWILNIQY IEQSHARGDF LDETLYEWGN PKAINLPTLA PEEEPIAAAV HRWRTELSAC 120
  121 GGGAFSDHRV ILSMNERSGA PIRNVLRAGG ACILEPTTPF SKDPVAKSAS HCFVDVKKAP 180
  181 LSTQDMEYLH KCGVQVLSQI AINAYLMNGR DADLGKYQLL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.154902
Match: 1jnxX
Description: Breast cancer associated protein, BRCA1
Matching Structure (courtesy of the PDB):

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