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View Structure Prediction Details

Protein: mus101-PA
Organism: Drosophila melanogaster
Length: 1425 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mus101-PA.

Description E-value Query
Range
Subject
Range
gi|11037277 - gi|11037277|gb|AAG27544.1|AF257463_1 BRCT-domain protein MUS101 [Drosophila melanogaster]
919.0 [0..1] [1425..1]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISMSMDET ICAYFVNNLK PGDGGVQEAD TLQQFEAARE LLGQQLAETQ IRQIKPSEGY  60
   61 PLIAAGNLTK KDVFVLTQFE GEFFEQLQQT RALILGPPCL ITCLRRNEPI PEGSSAIYST 120
  121 AMRDLQVSAT GITPQKKEEL SRLINWMGGI YFQSFGHRTT HLISNTIKSS KYEQATLNGV 180
  181 PVMHVDWVQY VWDQSRRSQR EG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 2owoA
Description: No description for 2owoA was found.

Predicted Domain #2
Region A:
Residues: [203-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IMATDPDFDK YRLPIFFGAN ITCSGLDVAR KDQVMRLVND NGGIYHRAFR SQVVDIVITE  60
   61 QTKTDTEKYK AAIRYKKDVL LPEWIFDSCN RGYALPTKDY EVRPGKTSST PT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1oqaA
Description: Solution structure of the BRCT-c domain from human BRCA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.911539062312394 bayes_pls_golite062009
protein binding 0.740170908668509 bayes_pls_golite062009
catalytic activity 0.00504703671568302 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [315-483]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTTRPGAAPG ADQTHLSDLS RISFVSGSRR MCSDLSTVNE SVSSVGSSSP AKQLLKQATS  60
   61 SGRNYQQVLA EIEPRQAKKA GAFLDGCCVY LSGFRSEERE KLNRVLNTGG ATRYDEANEG 120
  121 ISHIIVGQLD DAEYRQWQRD GLMGSVHVVR LDWLLESIRA GRVVSELVH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1wf6A
Description: The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.911539062312394 bayes_pls_golite062009
protein binding 0.740170908668509 bayes_pls_golite062009
catalytic activity 0.00504703671568302 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [484-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVSMPQNREP DVASPASKRT LRSMNHSFKQ PTLPIKKKLF DQEPDPVQEQ EHEEPDHTLL  60
   61 DQYSQDQGAV AQLPPADVSL LQPAASSTQM DIRQRVSVAN PKPPAEGLQL PDLSASTLSI 120
  121 DFDKLDY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [611-709]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FAGVSVYVHR ECFNEEFFNQ MLTECEAAQG LLVPSSFSDE VDFAIVSFEV AFDVKQLPVK  60
   61 ARHVVTELFL ESCMKKNQLL PIEYYHKHVP ATALRQPLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.154902
Match: 1cdzA
Description: DNA-repair protein XRCC1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.911539062312394 bayes_pls_golite062009
protein binding 0.740170908668509 bayes_pls_golite062009
catalytic activity 0.00504703671568302 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [710-875]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMTIVVSIYA GLERDFINAT AELLGASVNK TFIKKEKPLL VCPSAEGSKY EGAIKWNYPV  60
   61 VTSDWLVQCA RTGQKLPFVG YLVGKSPEDF PISPRLRDSN SRTARRPNES TLVAQPDVTM 120
  121 EEAENQPAGS VTPVTAGSPG APELTPLRNK RVSELAGIPG GSALHR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.14
Match: 2d8mA
Description: No description for 2d8mA was found.

Predicted Domain #7
Region A:
Residues: [876-1112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSNSTSSPDS PCTPLSQVGA QQYNLDFLEQ FVQRLDTEEG KDCVREIIRE MRENQTPELE  60
   61 RIRRQACTPV SRKHQRPAPG IPDFCLTPEF QQRMADDFER RWRLPTMKIK PDTPLAVIRQ 120
  121 RVMRITCETL GIEYEESNAK TPTLSESPST VKKKPPTRTT QATKLNFDRS PKTPKLSLGK 180
  181 KTPLRVSMGS PRSGTQSPFV PNTQSPIEAA PPRRSDGPTL SEEGQSTINF DKISFEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1113-1205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAVPVLAPDV PTVAPDVKQI TDYLKNCESR RNSLKRSHDN DMDCGESEVQ YVQPFESEGF  60
   61 ALGTEDMVDW RDPAEFNAAK RRSSGGSPKM QYA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1206-1425]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIPCFSISCG DDDEKRAELI ARITQLGGKV CENLVNYDDS CTHLLCERPN RGEKMLACIA  60
   61 AGKWILNIQY IEQSHARGDF LDETLYEWGN PKAINLPTLA PEEEPIAAAV HRWRTELSAC 120
  121 GGGAFSDHRV ILSMNERSGA PIRNVLRAGG ACILEPTTPF SKDPVAKSAS HCFVDVKKAP 180
  181 LSTQDMEYLH KCGVQVLSQI AINAYLMNGR DADLGKYQLL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.154902
Match: 1jnxX
Description: Breast cancer associated protein, BRCA1
Matching Structure (courtesy of the PDB):

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