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View Structure Prediction Details

Protein: Hira-PA
Organism: Drosophila melanogaster
Length: 1047 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Hira-PA.

Description E-value Query
Range		 Subject
Range
gi|148658115, gi... - gi|148658115|ref|YP_001278320.1| NB-ARC domain-containing protein [Roseiflexus sp. RS-1], gi|1485702...
 684.0 [0..95] [1000..703]

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Predicted Domain #1
Region A:
Residues: [1-117] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLKPAWVH HDDKQIFSVD IHKDCTKFAT GGQGSDCGRV VIWNLLPVLS DKAEFDADVP  60
   61 KMLCQMDQHL ACVNCVRWSQ NGQNLASGSD DKLIMIWRKS AGSSGVFGTG GMQKNHE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.19
Match: 1s4uX
Description: Crystal Structure analysis of the beta-propeller protein Ski8p
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [118-713] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SWKCFYTLRG HDGDVLDLAW SPNDVYLASC SIDNTVIIWD AQAFPHSVAT LKGHTGLVKG  60
   61 VSWDPLGRFL ASQSDDRSIK IWNTMNWSLS HTITEPFEEC GGTTHILRLS WSPDGQYLVS 120
  121 AHAMNGGGPT AQIIEREGWK CDKDFVGHRK AVTCVRFHNS ILSRQENDGS PSKPLQYCCL 180
  181 AVGSRDRSLS VWMTALQRPM VVIHELFNAS ILDLTWGPQE CLLMACSVDG SIACLKFTEE 240
  241 ELGKAISEEE QNAIIRKMYG KNYVNGLGKS APVLEHPQRL LLPQGDKPTK FPLSNNNEAN 300
  301 QRPISKQTET RTKDGKRRIT PMFIPLHEDG PTSLSMNIVS SSGSSTTALT SCSAAIGTLP 360
  361 AAAPTESAAT PLMPLEPLVS KIDLGRLDSR LKTQPASQRR QSLPFDPGQS NELLRTPRLE 420
  421 EHQSSTCSPS NLNVTATGKS EFVKAALDYR LHVSNGHLKT QHGMLAKVTA SDSKEMLWEF 480
  481 YVGSPLVNLN LCEKYAMLCS LDGSMRLISM ETGCPVFPAI SLTSSAVHCA FSPDNSLVGV 540
  541 LTECGLLRIW DIAKKVVSLA AGCLELLNKH GTAAQFSVTN QGMPLIGFPS GNSYSY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.69897
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.67009948605948 bayes_pls_golite062009
snoRNA binding 4.78410616474982 bayes_pls_golite062009
RNA binding 3.77273677738815 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.79445416141967 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
transcription repressor activity 2.29049708962212 bayes_pls_golite062009
protein binding 2.26925404328312 bayes_pls_golite062009
dynein binding 1.74989209255308 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
transcription corepressor activity 1.41752877005447 bayes_pls_golite062009
structural molecule activity 1.31060431370834 bayes_pls_golite062009
cytoskeletal protein binding 1.19593750149343 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
mRNA binding 1.05053985350578 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
DNA-dependent ATPase activity 0.625780732991652 bayes_pls_golite062009
actin binding 0.529861581509437 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
DNA helicase activity 0.220747580531792 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [714-883] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSLQSWLVL ATKDAIMYHG IRGTLPRDMD QMQQKFPLLS MQASSQNYFS FTGSMELRHS  60
   61 ESWQQCAKIR FIENQIKLCE ALQSLDELQH WHKMLTFQLA THGSEKRMRV FLDDLLSMPE 120
  121 PGISQFVPKL ELMQCVLDTL KPHSEWNRLH SEYTELLKEC KSERQKDIFA

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 8.356547
Match: PF07569.2
Description: No description for PF07569.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [884-959] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPAPPQQKTA SSAGSSPRSG EATGEEVTEK DGATAVAAAV VAGSRMAVTT GTSTTTTTTA  60
   61 SSSLSSSGSS SSTSGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [960-1047] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSSSSSSTS SLSVPQPAPS LSPEIQTLDS PTVCIDDEIL SASSSLPPLD TSPVEVSPAS  60
   61 TSGGAASTSP AASVAGSAPV SSSKTDQT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle