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View Structure Prediction Details

Protein: FBpp0308820
Organism: Drosophila melanogaster
Length: 485 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0308820.

Description E-value Query
Range
Subject
Range
gi|73976793 - gi|73976793|ref|XP_857617.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...
296.0 [0..3] [470..101]

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Predicted Domain #1
Region A:
Residues: [1-88]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNADKMQDQ EHDDEQSSDI EGSGDNVGRD DGTDDDDDSN GNMQQENGDG GNGGDGQEHS  60
   61 GDEEQHHSQD NEGNDNSAGQ QQQMQQVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.522879
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 3.75748736237159 bayes_pls_golite062009
nucleic acid binding 3.30499161454806 bayes_pls_golite062009
mRNA binding 2.67679675039933 bayes_pls_golite062009
binding 2.30438455421982 bayes_pls_golite062009
0.84389121154917 bayes_pls_golite062009
single-stranded RNA binding 0.61170301639809 bayes_pls_golite062009
poly-pyrimidine tract binding 0.40943492051131 bayes_pls_golite062009
protein binding 0.403675976995418 bayes_pls_golite062009
transcription regulator activity 0.361110886317161 bayes_pls_golite062009
mRNA 5'-UTR binding 0.18283446592068 bayes_pls_golite062009
DNA binding 0.139895000724487 bayes_pls_golite062009
translation repressor activity, nucleic acid binding 0.0860748299027598 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [89-277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTSATNLIIN YLPQDMTDRE LYNLFSGCGP INTCKIMRDF KTGYSFGYGF VDYKTESDSE  60
   61 DAIQKLNGFY VRNKRLKVSY ARPGGQSIKD TNLYVINLSR NINDDMLDRI FSPYGLIVQR 120
  121 NILRDKLTGR PRGVAFVRYN KREEAQEAIK ALNNTVPEGG SQPIWVRLAE EHGKAKAAQF 180
  181 MAQIGGGNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.09691
Match: 3sxlA
Description: Sex-lethal protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 3.75748736237159 bayes_pls_golite062009
nucleic acid binding 3.30499161454806 bayes_pls_golite062009
mRNA binding 2.67679675039933 bayes_pls_golite062009
binding 2.30438455421982 bayes_pls_golite062009
0.84389121154917 bayes_pls_golite062009
single-stranded RNA binding 0.61170301639809 bayes_pls_golite062009
poly-pyrimidine tract binding 0.40943492051131 bayes_pls_golite062009
protein binding 0.403675976995418 bayes_pls_golite062009
transcription regulator activity 0.361110886317161 bayes_pls_golite062009
mRNA 5'-UTR binding 0.18283446592068 bayes_pls_golite062009
DNA binding 0.139895000724487 bayes_pls_golite062009
translation repressor activity, nucleic acid binding 0.0860748299027598 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [278-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGGPPHMG PGGPMHPPHH HNNHHHNNHH NPHMPPHHHQ PQHPHQHPQH HPQLHHMQHH  60
   61 HPNNHNNNHP NNHHHNNNNN NHHNMGGPHP HHMQQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [373-485]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHPMGMNMGM GVNMGMGMGM GMPIHGGGGG GGGGGGGGGG GNFHHMAHRG EVFMLPLPIC  60
   61 SRFPSQPHPV GNGICHSPNK NSRFRLSRRP QASRTTIRYI AHSVADPVPT PTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.221849
Match: 1g9lA
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
eukaryotic initiation factor 4G binding 3.42010690672168 bayes_pls_golite062009
RNA binding 2.72440026355875 bayes_pls_golite062009
mRNA binding 2.69217140436626 bayes_pls_golite062009
single-stranded RNA binding 2.18428706002465 bayes_pls_golite062009
nucleic acid binding 2.17282382736847 bayes_pls_golite062009
poly(A) RNA binding 1.84786464421696 bayes_pls_golite062009
binding 1.42205067775429 bayes_pls_golite062009
poly-purine tract binding 1.35887811843216 bayes_pls_golite062009
catalytic activity 0.658135691360255 bayes_pls_golite062009
protein binding 0.137597344174086 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle