YRC Public Data Repository - Protein Structure Prediction

Protein:	FBpp0300849
Organism:	Drosophila melanogaster
Length:	1851 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0300849.

Description	E-value	Query Range	Subject Range
gi\|28261017 - gi\|28261017\|gb\|AAO32792.1\| scribbled [Drosophila melanogaster]	1223.0	[0..1]	[1851..1]

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Predicted Domain #1

Region A:
Residues: [1-640]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKCIPIFKG CNRQVEFVDK RHCSLPQVPE EILRYSRTLE ELFLDANHIR DLPKNFFRLH  60
   61 RLRKLGLSDN EIGRLPPDIQ NFENLVELDV SRNDIPDIPD DIKHLQSLQV ADFSSNPIPK 120
  121 LPSGFSQLKN LTVLGLNDMS LTTLPADFGS LTQLESLELR ENLLKHLPET ISQLTKLKRL 180
  181 DLGDNEIEDL PPYLGYLPGL HELWLDHNQL QRLPPELGLL TKLTYLDVSE NRLEELPNEI 240
  241 SGLVSLTDLD LAQNLLEALP DGIAKLSRLT ILKLDQNRLQ RLNDTLGNCE NMQELILTEN 300
  301 FLSELPASIG QMTKLNNLNV DRNALEYLPL EIGQCANLGV LSLRDNKLKK LPPELGNCTV 360
  361 LHVLDVSGNQ LLYLPYSLVN LQLKAVWLSE NQSQPLLTFQ PDTDAETGEQ VLSCYLLPQQ 420
  421 EYQPITPARD LESDSEPFEE REPSRTVVKF SEEATQEKET PFVRQNTPHP KDLKAKAQKL 480
  481 KVERSRNEEH ANLVTLPEEN GTKLAETPTE TRTIANNHQQ QPHPVQQPIV GVNSKQPVVV 540
  541 GVVTPTTTTV APTGVQGGSE GASSTANNVK AATAAVVAEL AATVGGSDEV QDDDEQEDEF 600
  601 ESDRRVGFQV EGEDDDFYKR PPKLHRRDTP HHLKNKRVQH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.045757
Match:	2a0zA
Description:	The molecular structure of toll-like receptor 3 ligand binding domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [641-714]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTDKQASEIL ANALASQERN DTTPQHSLSG KVTSPIEEEE QLEVEQEQQQ QQQQHPFDSS  60
   61 LSPISAGKTA EAST

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [715-821]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPDNLDGVTE LRLEQYEIHI ERTAAGLGLS IAGGKGSTPF KGDDDGIFIS RVTEAGPADL  60
   61 AGLKVGDKVI KVNGIVVVDA DHYQAVQVLK ACGAVLVLVV QREVTRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.154902
Match:	1g9oA
Description:	Na+/H+ exchanger regulatory factor, NHERF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
signal transducer activity	0.877891218909175	bayes_pls_golite062009
molecular transducer activity	0.877891218909175	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
transcription regulator activity	0.59879941754162	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
transcription activator activity	0.112015276833031	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [822-926]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGHPVFSEDG SVSQISVETR PLVADAPPAA SISHERYIPA PIEIVPQQQH LQQQQQQPIQ  60
   61 QVAPTHSYSG NVFATPTAAQ TVQPAVSAAP NGLLLNGREA PLSYI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [927-1030]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLHTTLIRDQ IGQGLGFSIA GGKGSPPFKD DCDGIFISRI TEGGLAYRDG KIMVGDRVMA  60
   61 INGNDMTEAH HDAAVACLTE PQRFVRLVLQ REYRGPLEPP TSPR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.0
Match:	1x5qA
Description:	Solution structure of the first PDZ domain of scribble homolog protein (hScrib)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
signal transducer activity	0.877891218909175	bayes_pls_golite062009
molecular transducer activity	0.877891218909175	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
transcription regulator activity	0.59879941754162	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
transcription activator activity	0.112015276833031	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [1031-1116]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPAVLNSLSP SGYLANRPAN FSRSVVEVEQ PYKYNTLATT TPTPKPTVPA SISNNNNTLP  60
   61 SSKTNGFATA AAATIDSSTG QPVPAP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [1117-1231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRTNSVPMGD GDIGAGSTTS GDSGEAQPSS LRPLTSDDFQ AMIPAHFLSG GSQHQVHVAR  60
   61 PNEVGVSAVT VNVNKPQPDL PMFPAAPTEL GRVTETITKS TFTETVMTRI TDNQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.0
Match:	1p1dA
Description:	Structural Insights into the Inter-domain Chaperoning of Tandem PDZ Domains in Glutamate Receptor Interacting Proteins
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
signal transducer activity	0.877891218909175	bayes_pls_golite062009
molecular transducer activity	0.877891218909175	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
transcription regulator activity	0.59879941754162	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
transcription activator activity	0.112015276833031	bayes_pls_golite062009

Predicted Domain #8

Region A:
Residues: [1232-1330]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEPLISEEVV LPKNQGSLGF SIIGGTDHSC VPFGTREPGI FISHIVPGGI ASKCGKLRMG  60
   61 DRILKVNEAD VSKATHQDAV LELLKPGDEI KLTIQHDPL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.83
Match:	1q7xA
Description:	Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	3.22145158985802	bayes_pls_golite062009
binding	2.49440226554254	bayes_pls_golite062009
signal transducer activity	0.892817370602462	bayes_pls_golite062009
molecular transducer activity	0.892817370602462	bayes_pls_golite062009
transporter activity	0.801614726348297	bayes_pls_golite062009
receptor binding	0.771579763169856	bayes_pls_golite062009
transmembrane transporter activity	0.708502382436949	bayes_pls_golite062009
transcription regulator activity	0.6225846026487	bayes_pls_golite062009
beta-catenin binding	0.54133173692519	bayes_pls_golite062009
PDZ domain binding	0.529933147165971	bayes_pls_golite062009
substrate-specific transporter activity	0.448136507940928	bayes_pls_golite062009
protein domain specific binding	0.412972149823917	bayes_pls_golite062009
cyclase inhibitor activity	0.352975560849784	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.352975560849784	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.258628194099861	bayes_pls_golite062009
transcription activator activity	0.105686987138254	bayes_pls_golite062009

Predicted Domain #9

Region A:
Residues: [1331-1428]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPGFQEVLLS KAEGERLGMH IKGGLNGQRG NPADPSDEGV FVSKINSVGA ARRDGRLKVG  60
   61 MRLLEVNGHS LLGASHQDAV NVLRNAGNEI QLVVCKGY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.39794
Match:	1ujuA
Description:	Solution structure of the fourth PDZ domain of human scribble (KIAA0147 protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	3.40921081688513	bayes_pls_golite062009
binding	2.6196222853442	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
signal transducer activity	0.877891218909175	bayes_pls_golite062009
molecular transducer activity	0.877891218909175	bayes_pls_golite062009
receptor binding	0.867295068429704	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
beta-catenin binding	0.740091060781601	bayes_pls_golite062009
cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
guanylate cyclase inhibitor activity	0.719523854982412	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
transcription regulator activity	0.59879941754162	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
transcription activator activity	0.112015276833031	bayes_pls_golite062009

Predicted Domain #10

Region A:
Residues: [1429-1611]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKSNLIHSIG QAGGMSTGFN SSASCSGGSR QGSRASETGS ELSQSQSVSS LDHEEDERLR  60
   61 QDFDVFASQK PDAQQPTGPS VLAAAAAMVH GASSPTPPAA TSNITPLPTA AAVASADLTA 120
  121 PDTPATQTVA LIHAEQQAHQ QQQQTQLAPL GQEKSTQEKV LEIVRAADAF TTVPPKSPSE 180
  181 HHE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11

Region A:
Residues: [1612-1851]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDKIQKTTTV VISKHTLDTN PTTPTTPAAP LSIAGAESAN SAGAPSPAVP ASTPGSAPVL  60
   61 PAVAVQTQTQ TTSTEKDEEE ESQLQSTPAS RDGAEEQQEE VRAKPTPTKV PKSVSDKKRF 120
  121 FESAMEDQHK PTQKTDKVFS FLSKDEVEKL RQEEERKIAT LRRDKNSRLL DAANDNIDKD 180
  181 AAQQRTKSNS NSSSGDDNDD SDQEEGIARG DSVDNAALGH FDDAEDMRNP LDEIEAVFRS 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions:

Predicted functions:

Predicted functions: