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View Structure Prediction Details

Protein: nhr-264
Organism: Caenorhabditis elegans
Length: 408 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-264.

Description E-value Query
Range
Subject
Range
gi|76631078 - gi|76631078|ref|XP_887036.1| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
269.0 [0..3] [405..46]

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Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAERQYGEF IYFCQNVGVI LFETCMIKPT FNVVKTAFPL KVYNYIKTKA SNFTKNSEPC  60
   61 QVCQDSASTR HHFGITSCTA CASFFRRTTM NQFTCNLDNN CSVSYKKKWV CRACRYNNCI 120
  121 RAGMSKDYIR RGNVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.39794
Match: 2a66A
Description: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [136-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETKNRKTFRK RTIRNSIRRN KSSLNRISEP VKMDQNSTSR SSTSSSIKHS SDTSTEFSKI  60
   61 LHLSNDELLQ FYLKEVERTM VQKQRGLAKN ALLAESMNEL MIISAYQNGL SMESCMHCPG 120
  121 VNSLEKEDVQ TLLKYFQFAN VWMDSVRAYS MSNVDIYETT PKDKRLSEYI QQVKLTLGSS 180
  181 FSQLKLNLYE FAALKSYCIW NMGFFETSIA MKIIAREHYI GVTAALRNYY RTQTKMSDMD 240
  241 IAIRIGDITL QIITVSNMFH DMAKLSYQCG LTF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 1xdkB
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.31508164334985 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 2.20996397516696 bayes_pls_golite062009
transcription regulator activity 2.02157665604796 bayes_pls_golite062009
DNA binding 1.47175550190876 bayes_pls_golite062009
signal transducer activity 1.430912689846 bayes_pls_golite062009
molecular transducer activity 1.430912689846 bayes_pls_golite062009
protein binding 1.34648900580465 bayes_pls_golite062009
nucleic acid binding 1.29377568150934 bayes_pls_golite062009
receptor activity 1.17902442273252 bayes_pls_golite062009
transcription activator activity 0.96843436755116 bayes_pls_golite062009
transcription factor activity 0.92060883178562 bayes_pls_golite062009
sequence-specific DNA binding 0.67007540744134 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle