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View Structure Prediction Details

Protein: Ect3-PA
Organism: Drosophila melanogaster
Length: 637 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ect3-PA.

Description E-value Query
Range
Subject
Range
BGAL_CANLF - Beta-galactosidase OS=Canis lupus familiaris GN=GLB1 PE=2 SV=3
487.0 [0..19] [634..28]

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Predicted Domain #1
Region A:
Residues: [1-472]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFSVVVLVA LLPLLGAVSA NRTFVVDYEK DQFLKDGEPF RFIAGSFHYF RAHPATWQRH  60
   61 LRTMRAAGLN AVTTYVEWSL HNPRDGVYVW SGIADLEHFI RLAVGEDLLV ILRPGPYICA 120
  121 ERDMGGFPYW LLNKYPGIQL RTADVNYLSE IRIWYTQLFA KMNKYLYGNG GPIIMVQVEN 180
  181 EYGSFYACDL NYRNWLRDET ESHVKGQAVL FTNDGPSVLR CGKIQGVLAT MDFGATNDLK 240
  241 PIWAKFRRYQ PKGPLVNAEY YPGWLTHWTE PMANVSTQSI TSTFINMLDH GASVNFYMFY 300
  301 GGTNFGFTAG ANDIGPGNYM ADITSYDYDA PMTEAGDPTP KYQALRRIIG RYLPLPNQPV 360
  361 PGPVPKRSYG TVRLTTCCSL LSSEARSRLS TGFVQSAKPK SFEALGQYSG LVLYETWLPS 420
  421 FQRDPSILSV PGLADRGYVY VDGEFVGILA RETPVFELPL SASAGRRFQI IV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.09691
Match: 1tg7A
Description: Native structure of beta-galactosidase from Penicillium sp.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, hydrolyzing O-glycosyl compounds 6.26329339735894 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 5.92180849080637 bayes_pls_golite062009
hydrolase activity 3.98075336331567 bayes_pls_golite062009
hexosaminidase activity 3.21852337137039 bayes_pls_golite062009
beta-N-acetylhexosaminidase activity 2.69072465526737 bayes_pls_golite062009
catalytic activity 1.85569074294201 bayes_pls_golite062009
glucosidase activity 1.85545420386612 bayes_pls_golite062009
galactosidase activity 1.26155841119987 bayes_pls_golite062009
sugar binding 1.05517664149942 bayes_pls_golite062009
alpha-glucosidase activity 1.00973231642658 bayes_pls_golite062009
beta-glucuronidase activity 0.55376725638834 bayes_pls_golite062009
mannosidase activity 0.48536369022293 bayes_pls_golite062009
carbohydrate binding 0.36193860645628 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.266938437560648 bayes_pls_golite062009
binding 0.129334455670168 bayes_pls_golite062009
beta-galactosidase activity 0.0137149865738109 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [473-637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENQGRINYGR QLNDFKGILR DVRLDKQVLS NWNMTQFPLE SYDNLEQLIT QSDEAVRQGF  60
   61 QELKKLRTML RTGPAIYHGQ LDIQKESDLA DTYLDMSGWG KGIVFVNGEN LGRYWPLVGP 120
  121 QVTLYVPAAV LKAGSNRLVV VEYQQTPASQ ELHFRDTPIL NARTV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.76
Match: 1bhgA
Description: beta-Glucuronidase; beta-Glucuronidase, domain 3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sugar binding 1.88707446766738 bayes_pls_golite062009
monosaccharide binding 1.5016957206605 bayes_pls_golite062009
hydrolase activity 1.33447645932315 bayes_pls_golite062009
binding 1.18625504714684 bayes_pls_golite062009
carbohydrate binding 1.13274900486168 bayes_pls_golite062009
peptidase activity 0.619147192549203 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.338739134947705 bayes_pls_golite062009
fucose binding 0.25045987594275 bayes_pls_golite062009
protein binding 0.0768945417872265 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle