YRC Public Data Repository - Protein Structure Prediction

Protein:	MED27-PA
Organism:	Drosophila melanogaster
Length:	293 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED27-PA.

Description	E-value	Query Range	Subject Range
gi\|157818903, gi... - gi\|62644833\|ref\|XP_216025.3\| PREDICTED: similar to transcriptional co-activator CRSP8 homolog [Rattu...	467.0	[0..1]	[291..11]
tr\|G3I9P4\|G3I9P4... - Mediator of RNA polymerase II transcription subunit 27 OS=Cricetulus griseus GN=I79_020298 PE=4 SV=1 MED27_PIG - Mediator of RNA polymerase II transcription subunit 27 OS=Sus scrofa GN=MED27 PE=2 SV=1	467.0	[0..1]	[291..11]
MED27_MOUSE - Mediator of RNA polymerase II transcription subunit 27 OS=Mus musculus GN=Med27 PE=2 SV=2	466.0	[0..1]	[291..11]
gi\|109109978 - gi\|109109978\|ref\|XP_001105126.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional act...	466.0	[0..1]	[291..11]
MED27_PONAB - Mediator of RNA polymerase II transcription subunit 27 OS=Pongo abelii GN=MED27 PE=2 SV=1 MED27 - mediator complex subunit 27 gi\|167773683 - gi\|167773683\|gb\|ABZ92276.1\| mediator complex subunit 27 [synthetic construct] MED27_PONPY - Mediator of RNA polymerase II transcription subunit 27 - Pongo pygmaeus (Orangutan)	466.0	[0..1]	[291..11]
MED27_BOVIN - Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus GN=MED27 PE=2 SV=1	465.0	[0..1]	[291..11]
gi\|73967722 - gi\|73967722\|ref\|XP_849826.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	464.0	[0..1]	[291..11]
gi\|50757265 - gi\|50757265\|ref\|XP_415455.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	456.0	[0..1]	[291..44]
gi\|55624172 - gi\|55624172\|ref\|XP_526874.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	447.0	[0..1]	[291..11]
MED27_DANRE - Mediator of RNA polymerase II transcription subunit 27 OS=Danio rerio GN=med27 PE=2 SV=1	445.0	[0..1]	[291..11]

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Predicted Domain #1

Region A:
Residues: [1-106]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLNSTLTA VKNLRSNVRL CFEHLADGTD GESGEESRNK FVNDFQERFA AINSQIREVE  60
   61 QLINGLPVPP TPYSLGNTAY LAQETSQDRQ ALYPQLVNSY KWMDKV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.952	N/A	N/A	a.47.2	t-snare proteins
View	Download	0.914	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.909	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.807	N/A	N/A	a.24.26	Description not found.
View	Download	0.792	N/A	N/A	a.47.2	t-snare proteins
View	Download	0.766	N/A	N/A	a.29.13	Description not found.
View	Download	0.765	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.760	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.710	N/A	N/A	a.7.6	Ribosomal protein S20
View	Download	0.700	N/A	N/A	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Predicted Domain #2

Region A:
Residues: [107-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDHSFLAFNN LNQNTLRRSY NYCSQKRQRL PFSSFNNDPD HIDKLLSEIN TPPHTSYRIF  60
   61 RPFGTNAVTI VTISNVMKAA IVFKGVLIEW VTVKGFDE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.675	a.1.1	Globin-like
View	Download	0.668	a.1.1	Globin-like
View	Download	0.655	b.36.1	PDZ domain-like
View	Download	0.650	b.36.1	PDZ domain-like
View	Download	0.604	a.4.1	Homeodomain-like
View	Download	0.576	a.74.1	Cyclin-like
View	Download	0.555	a.74.1	Cyclin-like
View	Download	0.547	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.535	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.535	a.4.6	C-terminal effector domain of the bipartite response regulators

Predicted Domain #3

Region A:
Residues: [205-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLEHDDLWAE SRYEVFRKVQ DHAHSAMLHF FSPTLPDLAV KSYITWLNSH VKLFLEPCKR  60
   61 CGKFVVNGLP PTWRDLRTLE PFHEDCRNC

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.995	N/A	N/A	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac
View	Download	0.995	N/A	N/A	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac
View	Download	0.916	N/A	N/A	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac
View	Download	0.911	N/A	N/A	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac
View	Download	0.885	N/A	N/A	a.24.9	alpha-catenin/vinculin
View	Download	0.874	N/A	N/A	a.24.9	alpha-catenin/vinculin
View	Download	0.867	N/A	N/A	a.47.2	t-snare proteins
View	Download	0.854	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.834	N/A	N/A	a.24.9	alpha-catenin/vinculin
View	Download	0.828	N/A	N/A	a.47.2	t-snare proteins

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits