YRC Public Data Repository - Protein Structure Prediction

Protein:	MED27-PA
Organism:	Drosophila melanogaster
Length:	293 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED27-PA.

Description	E-value	Query Range	Subject Range
gi\|157818903, gi... - gi\|62644833\|ref\|XP_216025.3\| PREDICTED: similar to transcriptional co-activator CRSP8 homolog [Rattu...	467.0	[0..1]	[291..11]
tr\|G3I9P4\|G3I9P4... - Mediator of RNA polymerase II transcription subunit 27 OS=Cricetulus griseus GN=I79_020298 PE=4 SV=1 MED27_PIG - Mediator of RNA polymerase II transcription subunit 27 OS=Sus scrofa GN=MED27 PE=2 SV=1	467.0	[0..1]	[291..11]
MED27_MOUSE - Mediator of RNA polymerase II transcription subunit 27 OS=Mus musculus GN=Med27 PE=2 SV=2	466.0	[0..1]	[291..11]
gi\|109109978 - gi\|109109978\|ref\|XP_001105126.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional act...	466.0	[0..1]	[291..11]
MED27_PONAB - Mediator of RNA polymerase II transcription subunit 27 OS=Pongo abelii GN=MED27 PE=2 SV=1 MED27 - mediator complex subunit 27 gi\|167773683 - gi\|167773683\|gb\|ABZ92276.1\| mediator complex subunit 27 [synthetic construct] MED27_PONPY - Mediator of RNA polymerase II transcription subunit 27 - Pongo pygmaeus (Orangutan)	466.0	[0..1]	[291..11]
MED27_BOVIN - Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus GN=MED27 PE=2 SV=1	465.0	[0..1]	[291..11]
gi\|73967722 - gi\|73967722\|ref\|XP_849826.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	464.0	[0..1]	[291..11]
gi\|50757265 - gi\|50757265\|ref\|XP_415455.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	456.0	[0..1]	[291..44]
gi\|55624172 - gi\|55624172\|ref\|XP_526874.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	447.0	[0..1]	[291..11]
MED27_DANRE - Mediator of RNA polymerase II transcription subunit 27 OS=Danio rerio GN=med27 PE=2 SV=1	445.0	[0..1]	[291..11]

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Predicted Domain #1

Region A:
Residues: [1-106]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLNSTLTA VKNLRSNVRL CFEHLADGTD GESGEESRNK FVNDFQERFA AINSQIREVE  60
   61 QLINGLPVPP TPYSLGNTAY LAQETSQDRQ ALYPQLVNSY KWMDKV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.952	N/A	N/A	a.47.2	t-snare proteins

Predicted Domain #2

Region A:
Residues: [107-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDHSFLAFNN LNQNTLRRSY NYCSQKRQRL PFSSFNNDPD HIDKLLSEIN TPPHTSYRIF  60
   61 RPFGTNAVTI VTISNVMKAA IVFKGVLIEW VTVKGFDE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [205-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLEHDDLWAE SRYEVFRKVQ DHAHSAMLHF FSPTLPDLAV KSYITWLNSH VKLFLEPCKR  60
   61 CGKFVVNGLP PTWRDLRTLE PFHEDCRNC

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.995	N/A	N/A	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits