YRC Public Data Repository - Protein Structure Prediction

Protein:	mRpL46-PA
Organism:	Drosophila melanogaster
Length:	258 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mRpL46-PA.

Description	E-value	Query Range	Subject Range
RM46_RAT - 39S ribosomal protein L46, mitochondrial OS=Rattus norvegicus GN=Mrpl46 PE=2 SV=1	327.0	[0..2]	[258..19]
MRPL46 - mitochondrial ribosomal protein L46	325.0	[0..4]	[257..21]
gi\|114658725 - gi\|114658725\|ref\|XP_510572.2\| PREDICTED: mitochondrial ribosomal protein L46 isoform 2 [Pan troglody...	320.0	[0..4]	[257..21]
gi\|109082282 - gi\|109082282\|ref\|XP_001088970.1\| PREDICTED: similar to mitochondrial ribosomal protein L46 isoform 2...	310.0	[0..2]	[257..19]
RM46_PONPY - 39S ribosomal protein L46, mitochondrial precursor - Pongo pygmaeus (Orangutan) RM46_PONAB - 39S ribosomal protein L46, mitochondrial OS=Pongo abelii GN=MRPL46 PE=2 SV=1	307.0	[0..4]	[257..23]
RM46_MOUSE - 39S ribosomal protein L46, mitochondrial OS=Mus musculus GN=Mrpl46 PE=1 SV=1	303.0	[0..2]	[258..19]
gi\|73951430 - gi\|73951430\|ref\|XP_536185.2\| PREDICTED: similar to mitochondrial ribosomal protein L46 [Canis famili...	303.0	[0..4]	[258..23]
RM46_BOVIN - 39S ribosomal protein L46, mitochondrial OS=Bos taurus GN=MRPL46 PE=2 SV=1	291.0	[0..6]	[258..23]
gi\|116127281, gi... - gi\|118788447\|ref\|XP_316723.3\| AGAP006684-PA [Anopheles gambiae str. PEST], gi\|116127281\|gb\|EAA11413.... AGAP006684-PA - mRpL46: 39S ribosomal protein L46, mitochondrial\|protein_coding\|2L:36681148:36682028:-1\|gene:AGAP006...	288.0	[0..1]	[258..4]
gi\|54641160, gi\|... - gi\|54641160\|gb\|EAL29910.1\| GA12628 [Drosophila pseudoobscura pseudoobscura], gi\|125976762\|ref\|XP_001... gi\|54641160\|gb\|E... - GA12628-PA [Drosophila pseudoobscura], GA12628 [Drosophila pseudoobscura pseudoobscura]	283.0	[0..1]	[258..1]

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Predicted Domain #1

Region A:
Residues: [1-84]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRRIVQVGA RELSRAQSST ASAEKWDLYA GVLVERLPVV SKSLNPLEKQ FQDLLWRVEY  60
   61 ENSLKSDHEL KHEREIVQAE LIKQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [85-258]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKIQVDLEDA GSKQTAQDLK DAYVEELKKF QLGSRTTPDD QANRTTSTDR CLDDTLYLLV  60
   61 QQKLGQQEHL ILPQGKREEG ESMRQTAERV LRESCGQELQ VLFYGNAPVG FHKYKYPRNQ 120
  121 RTETVGAKVF FYRASLRSGQ VPENLTKFEW LPKEALNEKL TNTAYAQSVK KFLL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.43
Match:	2azwA
Description:	Crystal structure of the MutT/nudix family protein from Enterococcus faecalis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.616957420082379	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.128023358756584	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.126599262279799	bayes_pls_golite062009
hydrolase activity	0.0931531162120938	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: