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View Structure Prediction Details

Protein: CG5594-PB
Organism: Drosophila melanogaster
Length: 1028 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG5594-PB.

Description E-value Query
Range
Subject
Range
gi|73999688 - gi|73999688|ref|XP_535414.2| PREDICTED: similar to Solute carrier family 12, member 6 (Electroneutra...
796.0 [0..4] [1028..76]

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Predicted Domain #1
Region A:
Residues: [1-93]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSNSAKDDS DEMEIIPSEH NGTVHETKNE DSGDIHRAEE NQKSSIDPNL YLYDDDLETR  60
   61 PHISTFISSI ANYENTIPAA TDPDAKPAAP SAR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [94-193]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTLIGVFLP CIQNIFGVIL FIRLTWVVGT AGAVCGFLIV LTCCCVTMLT AISMSAIATN  60
   61 GVVPAGGSYF MISRSLGPEF GGAVGMLFYT GTTLAAAMYI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 2a65A
Description: Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [194-716]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGAVEIVLTY MAPWASIFGD FTKDADAMYN NFRVYGTLLL IFMGLIVFLG VKFVNKFATV  60
   61 ALACVILSII AVYVGIFDNI HGNEKLYMCV LGKRLLKDIP LENCTKEDSF LRDIYCPDGK 120
  121 CEEYYLANNV TKVKGIKGLA SGVFYDNIFP SFLEKGQFIS YGKSAIDIEN TSGESYNQIM 180
  181 ADITTSFTLL IGIFFPSVTG IMAGSNRSGD LADAQKSIPI GTICAILTTS TVYLSSVMFF 240
  241 AGTVDNLLLR DKFGQSIGGK LVVANIAWPN QWVILIGSFL STLGAGLQSL TGAPRLLQAI 300
  301 ARDEIIPFLA PFAKSSKRGE PTRALLLTIV ICQCGILLGN VDLLAPLLSM FFLMCYGFVN 360
  361 LACAVQTLLR TPNWRPRFKF YHWSLSLIGL TLCISVMIMT SWYFALIAMG MAIIIYKYIE 420
  421 YRGAEKEWGD GIRGMALTAA RYSLLRLEEG PPHTKNWRPQ ILVLSKLNDN LLPKYRKIFS 480
  481 FATQLKAGKG LTICVSVIKG DHTKITNKAV DAKATLRKYM TDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.045757
Match: 1ar1A
Description: Bacterial aa3 type cytochrome c oxidase subunit I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
monovalent inorganic cation transmembrane transporter activity 6.93719418697328 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 6.67949994760371 bayes_pls_golite062009
cation transmembrane transporter activity 6.50939400533716 bayes_pls_golite062009
ion transmembrane transporter activity 6.40081133240949 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 6.02701109829891 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 5.9695962563814 bayes_pls_golite062009
transporter activity 4.2806100513341 bayes_pls_golite062009
transmembrane transporter activity 4.19885907933483 bayes_pls_golite062009
substrate-specific transporter activity 4.09889747645813 bayes_pls_golite062009
binding 1.32681091506724 bayes_pls_golite062009
heme-copper terminal oxidase activity 1.27735515053931 bayes_pls_golite062009
copper ion binding 1.08782819178001 bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors 0.803860393147327 bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor 0.803860393147327 bayes_pls_golite062009
cytochrome-c oxidase activity 0.803860393147327 bayes_pls_golite062009
active transmembrane transporter activity 0.349031670056176 bayes_pls_golite062009
primary active transmembrane transporter activity 0.336122020727214 bayes_pls_golite062009
protein binding 0.335149649581279 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [717-799]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVKGFCDVLV AQQIGEGLSS VIQTIGLGGM KPNTVIIGWP YSWRQEGRNS WKTFIQTVRT  60
   61 VAACHMALMV PKGINFYPES NHK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [800-941]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGGNIDIWWI VHDGGLLMLL PFLLKQHRTW RNCKLRIFTV AQIEDNSIQM KKDLKTFLYH  60
   61 LRIEADVEVV EMNNSDISAY TYERTLMMEQ RNQMLRALGL NKKENSKVDS QNDEKRNSID 120
  121 LDGPENADTP ETTSNKDEST EK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [942-1028]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADGDFKSSVK PDEFNVRRMH TAIKLNEVIV EKSQDAQLVI MNLPGPPREV RAERERNYME  60
   61 FLEVLTEGLE KVLMVRGGGR EVITIYS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle