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View Structure Prediction Details

Protein: FBpp0292546
Organism: Drosophila melanogaster
Length: 1091 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0292546.

Description E-value Query
Range
Subject
Range
gi|125807730, gi... - gi|54635677|gb|EAL25080.1| GA17566-PA [Drosophila pseudoobscura], gi|125807730|ref|XP_001360505.1| G...
403.0 [0..15] [1090..1]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPMPQMPPM PPLQLDKNTL VGHLREHERA LIFGSRSPEE APEFKLVHLA QQRPEEQQRL  60
   61 EERKRPGEAE QHGGNPHQRR QRRSLPSEDG NGPLPPEEEE QEAGEDVEAR LQLQQSPQLI 120
  121 DDAFIFIRRT ENGTQFVEHS PQLLKRLERC FYRSPAAALD LCEPGNVRGV FQQNGSDLVI 180
  181 HPLPARFGTG 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [191-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 THVLYQARVD KSGGGYSEAS SRRTASPLDS QLQFEPDAEE FNEPRRRLRA QSQLQSPLRL  60
   61 RFQPRHHHPH QHHQQRRRRY IGDAPRSRW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [280-716]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDIPEELFIE TAIFVDSDLY AHMQKNFPTN TESKVVSFLL AMINGVQLLY HHPTLGRRIN  60
   61 FVLKRLEIWK SWDPPGLVRS RDVENYLNSF CKWQEKLNPF SDADPLHYDH ALVLTGLDLV 120
  121 TYDKGKANSQ VVGMATVKGM CTSIYSCTIN EAKHFESVFV VAHEIGHNLG MRHDAKEISC 180
  181 DPTMHIMSPK LGSGKVTWSK CSRTYLEDFL MDPQAECLFD RDSFAGPWDH TAGGRLPGER 240
  241 FNANQQCMLR FGKNFMQAST QSKMEICRDL HCRQDGLPWT SHPALEGTEC GPNMWCRGGT 300
  301 CEARSSKQGS YSALKSWPPE HIPEATHEKI IRHEPNRIPP LLHDYNPMDN ELPGSPSNWG 360
  361 EWSEPSACES GCLYGQSRRL LEGSTGLRTL NRSCLNFPSR CIGRDRRFVT CNTPQCHKVP 420
  421 VQTINDFATQ VCMQARK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.0
Match: 2dw0A
Description: No description for 2dw0A was found.

Predicted Domain #4
Region A:
Residues: [717-1011]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDPELTGEGQ QLPSTLDASC KIFCRTRTNG TKSRRWTFPD GTTCKAKQHN PEDITYCISG  60
   61 RCERFSCDNS TSNFFKMDSS FCEARSVRPT RDSSDQESRQ QTNRQRYAER QEGKPQKNHY 120
  121 ENEVAKRPSY GQGNHINAPA SPYKRRNYHK PYPPEIPRPP PPASASLIAL DRSSSSESEW 180
  181 VAHPGCHSNC MTDSKGVQGV TSRLTGVESI QLCSYRIQPC ERLQTAAEYA EQTCARYRQK 240
  241 VRGLSGHGAQ ISASIDEPDR SCRVGCQDEF IKYRYYLVNG RNGHFPPGTR CSPVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.35439555347435 bayes_pls_golite062009
growth factor activity 2.88505170485169 bayes_pls_golite062009
binding 1.87945097283832 bayes_pls_golite062009
glycosaminoglycan binding 1.68241417866789 bayes_pls_golite062009
protein binding 1.62006751483747 bayes_pls_golite062009
heparin binding 1.30139703416568 bayes_pls_golite062009
pattern binding 1.26957983931218 bayes_pls_golite062009
polysaccharide binding 1.11978732751628 bayes_pls_golite062009
ErbB-2 class receptor binding 0.847169032980225 bayes_pls_golite062009
carbohydrate binding 0.72748768329894 bayes_pls_golite062009
epidermal growth factor receptor binding 0.66302254098895 bayes_pls_golite062009
transcription factor binding 0.556175571276939 bayes_pls_golite062009
ErbB-3 class receptor binding 0.37496803961958 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1012-1091]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRYCVYGRCL EFGDDDLPLD KTHISLGQLR TRRKRSSISN DLFNITEIFI KPSHSDISAE  60
   61 NIEFTQPIHV SADELSSKSR 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle