YRC Public Data Repository - Protein Structure Prediction

Protein:	CkIIbeta2-PA
Organism:	Drosophila melanogaster
Length:	219 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CkIIbeta2-PA.

Description	E-value	Query Range	Subject Range
gi\|73972260 - gi\|73972260\|ref\|XP_532075.2\| PREDICTED: similar to casein kinase 2, beta subunit [Canis familiaris]	383.0	[0..1]	[196..90]
gi\|56201309 - gi\|56201309\|dbj\|BAD72911.1\| CkIIbeta2 [Drosophila simulans] gi\|194126641, gi... - gi\|56201328\|dbj\|BAD72929.1\| CkIIbeta2 [Drosophila sechellia], gi\|195336072\|ref\|XP_002034671.1\| casei...	380.0	[0..1]	[219..1]
gi\|168985483, gi... - gi\|66347790\|emb\|CAI18393.2\| casein kinase 2, beta polypeptide [Homo sapiens], gi\|168986040\|emb\|CAQ10... ENSPTRT00000033199 - null gi\|109070470 - gi\|109070470\|ref\|XP_001112540.1\| PREDICTED: similar to casein kinase 2, beta subunit isoform 2 [Maca...	380.0	[0..1]	[196..20]
gi\|181155 - gi\|181155\|gb\|AAA52123.1\| casein kinase II beta subunit [Homo sapiens]	377.0	[0..1]	[196..1]
gi\|51261191 - gi\|51261191\|gb\|AAH78807.1\| Csnk2b protein [Rattus norvegicus]	377.0	[0..1]	[196..27]
CSK2B_DANRE - Casein kinase II subunit beta OS=Danio rerio GN=csnk2b PE=2 SV=1 gi\|11280586, gi\|... - gi\|7672353\|gb\|AAF66446.1\|AF133088_1 CK2 beta subunit [Cyprinus carpio], gi\|11280586\|pir\|\|JC7269 prot... gi\|223649430, gi... - gi\|223649430\|gb\|ACN11473.1\| Casein kinase II subunit beta [Salmo salar], gi\|223648390\|gb\|ACN10953.1\|...	376.0	[0..1]	[196..1]
tr\|G3HZG2\|G3HZG2... - Casein kinase II subunit beta OS=Cricetulus griseus GN=H671_1g2786 PE=3 SV=1 gi\|53734598 - gb\|AAH83993.1\| Unknown (protein for MGC:98116) [Xenopus laevis] CSK2B_RAT - Casein kinase II subunit beta OS=Rattus norvegicus GN=Csnk2b PE=1 SV=1 CSNK2B - casein kinase 2, beta polypeptide CSK2B_PIG - Casein kinase II subunit beta OS=Sus scrofa GN=CSNK2B PE=2 SV=1 CSK2B_RABIT - Casein kinase II subunit beta OS=Oryctolagus cuniculus GN=CSNK2B PE=2 SV=1 gi\|213688918, gi... - gi\|215983072\|ref\|NP_001135983.1\| casein kinase 2, beta polypeptide [Ovis aries], gi\|213688918\|gb\|ACJ... CSK2B_MOUSE - Casein kinase II subunit beta OS=Mus musculus GN=Csnk2b PE=1 SV=1 gi\|109070472 - gi\|109070472\|ref\|XP_001112478.1\| PREDICTED: similar to casein kinase 2, beta subunit isoform 1 [Maca... CSK2B_CHICK - Casein kinase II subunit beta OS=Gallus gallus GN=CSNK2B PE=2 SV=1 ENSPTRT00000057498 - null tr\|M3W831\|M3W831... - Casein kinase II subunit beta OS=Felis catus GN=CSNK2B PE=3 SV=1 CSK2B_BOVIN - Casein kinase II subunit beta OS=Bos taurus GN=CSNK2B PE=1 SV=1 gi\|194223340 - gi\|194223340\|ref\|XP_001917725.1\| PREDICTED: similar to casein kinase 2, beta polypeptide isoform 1 [...	376.0	[0..1]	[196..1]
CSK2B_XENLA - Casein kinase II subunit beta OS=Xenopus laevis GN=csnk2b PE=1 SV=1 gi\|49899997, gi\|... - gi\|89271289\|emb\|CAJ82633.1\| casein kinase 2, beta subunit [Xenopus tropicalis], gi\|52346076\|ref\|NP_0...	376.0	[0..1]	[196..1]
gi\|60834087 - gi\|60834087\|gb\|AAX37079.1\| casein kinase 2 beta polypeptide [synthetic construct]	376.0	[0..1]	[196..1]

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Predicted Domain #1

Region A:
Residues: [1-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDSDESSWI HWFCKQRGNE FFCEVDEEYI QDKFNLNFLD SNVKNYKCAL EVILDLNPGS  60
   61 ASEDPAEPEL EASAEKLYGL IHARFILTNR GIELMLDKYN KGEFGTCPRA FCHSQPVLPI 120
  121 GLSDNPGEDM VRIYCPKCND VYIPKASRHS NLDGAFFGTG FPHMFFMEKP DARPKRAKQK 180
  181 FVPRLYGFKI HPTAYRTAAE IQKDVTMTPV GEIDSPSHI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.0
Match:	1jwhC
Description:	Casein kinase II beta subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein kinase regulator activity	4.14878012076359	bayes_pls_golite062009
kinase regulator activity	4.09603095102334	bayes_pls_golite062009
enzyme regulator activity	2.91779610785511	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.79245883940915	bayes_pls_golite062009
protein kinase activity	2.75473427458132	bayes_pls_golite062009
kinase activity	2.66515798949431	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.39333807060713	bayes_pls_golite062009
protein serine/threonine kinase activity	1.99491617326192	bayes_pls_golite062009
binding	1.85951177140712	bayes_pls_golite062009
transferase activity	1.77218599619559	bayes_pls_golite062009
protein binding	1.4657010373022	bayes_pls_golite062009
catalytic activity	0.2012862421225	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: