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View Structure Prediction Details

Protein: garz-PA
Organism: Drosophila melanogaster
Length: 1740 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for garz-PA.

Description E-value Query
Range		 Subject
Range
garz-PB - The gene gartenzwerg is referred to in FlyBase by the symbol Dmel\garz (CG8487, FBgn0033714). It is ...
 1498.0 [0..1] [1700..1]

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Predicted Domain #1
Region A:
Residues: [1-571] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALPGNGIYV VRGEMATLMT AMRRGTRWNA TAYVDDENDS LLKLFIDLKH ELNRIEDLRQ  60
   61 IEPQVFLAPF LEVIRTADAT GPLTSLALAS VNKLLSYGLI DPTSPNLADI VERIADAVTH 120
  121 ARFMGTDQSS DGVTFMRVIE VLHTLIRSPE GAAVSNVSMC EVMLSCFKIS FEPRLSELLR 180
  181 RSAEKSLKDM VLLFFMRLPQ FAEERSDTML QKRFTIGDAA SGATQEKLKR KTVAQAQTAP 240
  241 RKSSAVEEPP QTPQSANLTV PGHLKAPILA TTPASPAGNI LDMQGKITQT PTTTASTGED 300
  301 ETTVPETPVI QVESTESEPL LDGETGEATS TLAEANSSEY INSVGVRFTQ QSTDHDVTSL 360
  361 SPYGLPFIQE LFRFLIILCN PLDKQNSDSM MHTGLSLLTV AFEVAADNIG KYEGLLELVK 420
  421 DDLCRNLISL LSSERLSIFA ADLQLCFLLF ESLRGHLKFQ LEAYLRKLSE IIASDNPKTP 480
  481 YEMRELALDN LLQLWRIPGF VTELYINYDC DLYCTDMFES LTNLLSKYTL SATNAVYSTH 540
  541 IISMDTLLSV IDSIERNCAA SKNSSNNRES L

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.14
Match: 1m5nS
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 3.54751411727402 bayes_pls_golite062009
binding 2.38363524631144 bayes_pls_golite062009
transporter activity 2.3766833486706 bayes_pls_golite062009
substrate-specific transporter activity 1.87445049214426 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
clathrin binding 1.81128105854389 bayes_pls_golite062009
protein transmembrane transporter activity 1.29496918547173 bayes_pls_golite062009
transmembrane transporter activity 1.2724388835449 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.80477645195818 bayes_pls_golite062009
active transmembrane transporter activity 0.260663498540354 bayes_pls_golite062009
primary active transmembrane transporter activity 0.0128158555898987 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.00672548245940896 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [572-856] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEAAPATGGS RHSRHNSGLE GIVIDSGNSV AAEEKVENIA SFINASSHRL RLQSGGEGVG  60
   61 ITSEQLAKVK QKKRLLSQGT ERFNQRPEKG IQYLQEHGIL NAELDPMQVA LFLRENPGLD 120
  121 KKMIGEYISK KKNVDSKILI NFVDSFDFTG LRVDQALRLY LETFRLPGEA PLIFLVLEHF 180
  181 SDHWHKQNQD PFANVDAAFR LAYAIIMLNM DQHNSNAKRL NVPMTLEDFT KNLRGLNGGE 240
  241 DFDQEMLAQV FNAIKNEEIV MPAEQTGLVR ENYQWKVLLR RGDTH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.045757
Match: 1r8mE
Description: SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO WITH BREFELDIN A-SENSITIZING MUTATIONS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ARF guanyl-nucleotide exchange factor activity 6.57705646633597 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.16463533550388 bayes_pls_golite062009
GTPase regulator activity 2.14281327181824 bayes_pls_golite062009
small GTPase regulator activity 2.10666233446144 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.03073529575688 bayes_pls_golite062009
enzyme regulator activity 1.95578809138334 bayes_pls_golite062009
binding 1.3334812784277 bayes_pls_golite062009
protein binding 0.917306986228715 bayes_pls_golite062009
phosphoinositide binding 0.0750646331148792 bayes_pls_golite062009
phospholipid binding 0.0172309833091902 bayes_pls_golite062009
cytoskeletal protein binding 0.00476738027966683 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [857-1635] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGHFHYVHDA SYDVEIFNIV WGASLSALSF MFDKSTETGY QRTLAGFSKS AAISAHYNLH  60
   61 SDFDALVLTL CKFTTLLSSV EQHEPAPANN ETQQAVNFGL NGKAQAAMRT VFLLVHDYGD 120
  121 CLRESWKHIL DLYLQLFRLK LLPKSLIEVE DFCEANGKAM LILEKPREKQ ESGLFSSLYS 180
  181 FISSEGQREP TYEEQDFIKL GRKCIKECQL DQMLQESKFV QLESLQELLK CVLALLKAPQ 240
  241 GHKSIGLPYA EDQTVFWMEF LVKIVVHNRD RMIPLWPAVR DQMYLLLMGS ASCGYDYLLN 300
  301 RCIVAVLKLA IYLMRNEELC PIVLQSLKML LMLKPALLLR ISKQISIGIY ELLKTSAQNI 360
  361 HSEQDWQIIF NLLECVGAGA VPPNYDDAQL PLPPNGSAKS DGAISGEEDA TAVPERGYTS 420
  421 DSEITKASAA PAVSSPSAEN WILVNNKDSE LTTASRPQSP PSLSAPPVNT LVYNCQLLDH 480
  481 APFALFKCWD SLAFIVRSVA HITPYNFEAC VRCIRIFVEA CRDGGIRQRR KLESAAKQKS 540
  541 SKKRSERKPG MASSASSSNL TLLTGDPSDN QINGNAAEQE DLAQRYEQLS IQLLDLMYTL 600
  601 YTRTAQIFRW WAEEGCTVPQ SAALWSPGWC PLLQGIARLA MDRRREVRTH AISCLQQRAL 660
  661 LVHDLQTLSG TEWCSCFHQV LFPLLNELLP ESNAAGQLDA ALLEESRIRT ATIMSKVFLQ 720
  721 HLTTLIELGN AFNELWLDIL DYIERFMKVG SDTLSEQMQE ILKNMLLVMH SVRVFHNQD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.26
Match: 2ie3A
Description: No description for 2ie3A was found.

Predicted functions:

Term Confidence Notes
protein transporter activity 3.54751411727402 bayes_pls_golite062009
binding 2.38363524631144 bayes_pls_golite062009
transporter activity 2.3766833486706 bayes_pls_golite062009
substrate-specific transporter activity 1.87445049214426 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
clathrin binding 1.81128105854389 bayes_pls_golite062009
protein transmembrane transporter activity 1.29496918547173 bayes_pls_golite062009
transmembrane transporter activity 1.2724388835449 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.80477645195818 bayes_pls_golite062009
active transmembrane transporter activity 0.260663498540354 bayes_pls_golite062009
primary active transmembrane transporter activity 0.0128158555898987 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.00672548245940896 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1636-1740] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSLQQALWEL TWRRIGEFLP NLKEELFHDE DSITPAVSLD YTQIRFAHST GTTDYSLSLP  60
   61 LYGYSPKISS ISASKCDTLP ATQRKKPWAK LRSKLKLLKK VGKKN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.953
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle