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Protein Overview: garz-PB

General Information:
Name(s) found: garz-PB / FBpp0087010 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene gartenzwerg is referred to in FlyBase by the symbol Dmel\garz (CG8487, FBgn0033714). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8214179..8221327. It has the cytological map location 48F8-48F10. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: phagocytosis, engulfment. 3 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; eye; intersegmental nerve; eye photoreceptor cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1983 amino acids

    Gene Ontology:
    Cellular Component: Golgi-associated vesicle [ISS]
    Biological Process: ER to Golgi vesicle-mediated transport [ISS]
    phagocytosis, engulfment [IMP]
    intra-Golgi vesicle-mediated transport [ISS]
    regulation of ARF protein signal transduction [IEA]
    Molecular Function: ARF guanyl-nucleotide exchange factor activity [IEA]
    guanyl-nucleotide exchange factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALPGNGIYV VRGEMATLMT AMRRGTRWNA TAYVDDENDS LLKLFIDLKH ELNRIEDLRQ  60
   61 IEPQVFLAPF LEVIRTADAT GPLTSLALAS VNKLLSYGLI DPTSPNLADI VERIADAVTH 120
  121 ARFMGTDQSS DGVTFMRVIE VLHTLIRSPE GAAVSNVSMC EVMLSCFKIS FEPRLSELLR 180
  181 RSAEKSLKDM VLLFFMRLPQ FAEERSDTML QKRFTIGDAA SGATQEKLKR KTVAQAQTAP 240
  241 RKSSAVEEPP QTPQSANLTV PGHLKAPILA TTPASPAGNI LDMQGKITQT PTTTASTGED 300
  301 ETTVPETPVI QVESTESEPL LDGETGEATS TLAEANSSEY INSVGVRFTQ QSTDHDVTSL 360
  361 SPYGLPFIQE LFRFLIILCN PLDKQNSDSM MHTGLSLLTV AFEVAADNIG KYEGLLELVK 420
  421 DDLCRNLISL LSSERLSIFA ADLQLCFLLF ESLRGHLKFQ LEAYLRKLSE IIASDNPKTP 480
  481 YEMRELALDN LLQLWRIPGF VTELYINYDC DLYCTDMFES LTNLLSKYTL SATNAVYSTH 540
  541 IISMDTLLSV IDSIERNCAA SKNSSNNRES LPEAAPATGG SRHSRHNSGL EGIVIDSGNS 600
  601 VAAEEKVENI ASFINASSHR LRLQSGGEGV GITSEQLAKV KQKKRLLSQG TERFNQRPEK 660
  661 GIQYLQEHGI LNAELDPMQV ALFLRENPGL DKKMIGEYIS KKKNVDSKIL INFVDSFDFT 720
  721 GLRVDQALRL YLETFRLPGE APLIFLVLEH FSDHWHKQNQ DPFANVDAAF RLAYAIIMLN 780
  781 MDQHNSNAKR LNVPMTLEDF TKNLRGLNGG EDFDQEMLAQ VFNAIKNEEI VMPAEQTGLV 840
  841 RENYQWKVLL RRGDTHDGHF HYVHDASYDV EIFNIVWGAS LSALSFMFDK STETGYQRTL 900
  901 AGFSKSAAIS AHYNLHSDFD ALVLTLCKFT TLLSSVEQHE PAPANNETQQ AVNFGLNGKA 960
  961 QAAMRTVFLL VHDYGDCLRE SWKHILDLYL QLFRLKLLPK SLIEVEDFCE ANGKAMLILE1020
 1021 KPREKQESGL FSSLYSFISS EGQREPTYEE QDFIKLGRKC IKECQLDQML QESKFVQLES1080
 1081 LQELLKCVLA LLKAPQGHKS IGLPYAEDQT VFWMEFLVKI VVHNRDRMIP LWPAVRDQMY1140
 1141 LLLMGSASCG YDYLLNRCIV AVLKLAIYLM RNEELCPIVL QSLKMLLMLK PALLLRISKQ1200
 1201 ISIGIYELLK TSAQNIHSEQ DWQIIFNLLE CVGAGAVPPN YDDAQLPLPP NGSAKSDGAI1260
 1261 SGEEDATAVP ERGYTSDSEI TKASAAPAVS SPSAENWILV NNKDSELTTA SRPQSPPSLS1320
 1321 APPVNTLVYN CQLLDHAPFA LFKCWDSLAF IVRSVAHITP YNFEACVRCI RIFVEACRDG1380
 1381 GIRQRRKLES AAKQKSSKKR SERKPGMASS ASSSNLTLLT GDPSDNQING NAAEQEDLAQ1440
 1441 RYEQLSIQLL DLMYTLYTRT AQIFRWWAEE GCTVPQSAAL WSPGWCPLLQ GIARLAMDRR1500
 1501 REVRTHAISC LQQRALLVHD LQTLSGTEWC SCFHQVLFPL LNELLPESNA AGQLDAALLE1560
 1561 ESRIRTATIM SKVFLQHLTT LIELGNAFNE LWLDILDYIE RFMKVGSDTL SEQMQEILKN1620
 1621 MLLVMHSVRV FHNQDGSLQQ ALWELTWRRI GEFLPNLKEE LFHDEGKRAQ TLTNPAPQAA1680
 1681 VAAAPQQQLP AVTILPRQTQ VSNELVVSAP TPPAATPLLG SPVESPRRSI ILQPPMADVL1740
 1741 QQPPSFVFAQ PIIVPPQPPA VTDPIPPSTL LPDLVNEATA AAVQATTTSP THSPQEAEQP1800
 1801 ASIVQQTNIV TTNNTYNSYA IEVPMAPETT AEQFGQQQQQ LLYQQYYQQY QAQQQQLPAP1860
 1861 ASDPAINVPI SHLLAGNAYP SLPKMPQASI VHSFAPVYES QAATSGAGTA AADIYQEYVQ1920
 1921 NPYNLTLQQH PQQQLHQQQQ QQQQQATGMA NAFPAVATPA NYFNVNVDPS SIPPGSELLY1980
 1981 GQQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..575] FFAS03 1.14 Importin beta
    2 View Details [576..855] PSI-BLAST 87.0 SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO WITH BREFELDIN A-SENSITIZING MUTATIONS
    3 View Details [856..933] PSI-BLAST 4.39794 Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,3,4,5)P4
    4 View Details [934..1604] FFAS03 0.989 Adaptin beta subunit N-terminal fragment
    5 View Details [1605..1983] PSI-BLAST 9.154902 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  3.54751411727402 bayes_pls_golite062009
  • binding
    		•  2.38363524631144 bayes_pls_golite062009
  • transporter activity
    		•  2.3766833486706 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.87445049214426 bayes_pls_golite062009
  • protein binding
    		•  1.81870125631028 bayes_pls_golite062009
  • clathrin binding
    		•  1.81128105854389 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.29496918547173 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.2724388835449 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.80477645195818 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.260663498540354 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0128158555898987 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.00672548245940896 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ARF guanyl-nucleotide exchange factor activity
    		•  6.57705646633597 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.16463533550388 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.14281327181824 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  2.10666233446144 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.03073529575688 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.95578809138334 bayes_pls_golite062009
  • binding
    		•  1.3334812784277 bayes_pls_golite062009
  • protein binding
    		•  0.917306986228715 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.0750646331148792 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.00476738027966683 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein transporter activity
    		•  3.54751411727402 bayes_pls_golite062009
  • binding
    		•  2.38363524631144 bayes_pls_golite062009
  • transporter activity
    		•  2.3766833486706 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.87445049214426 bayes_pls_golite062009
  • protein binding
    		•  1.81870125631028 bayes_pls_golite062009
  • clathrin binding
    		•  1.81128105854389 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.29496918547173 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.2724388835449 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.80477645195818 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.260663498540354 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0128158555898987 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.00672548245940896 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle