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View Structure Prediction Details

Protein: garz-PB
Organism: Drosophila melanogaster
Length: 1983 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for garz-PB.

Description E-value Query
Range		 Subject
Range
garz-PA - The gene gartenzwerg is referred to in FlyBase by the symbol Dmel\garz (CG8487, FBgn0033714). It is ...
 1703.0 [0..1] [1719..1]

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Predicted Domain #1
Region A:
Residues: [1-575] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALPGNGIYV VRGEMATLMT AMRRGTRWNA TAYVDDENDS LLKLFIDLKH ELNRIEDLRQ  60
   61 IEPQVFLAPF LEVIRTADAT GPLTSLALAS VNKLLSYGLI DPTSPNLADI VERIADAVTH 120
  121 ARFMGTDQSS DGVTFMRVIE VLHTLIRSPE GAAVSNVSMC EVMLSCFKIS FEPRLSELLR 180
  181 RSAEKSLKDM VLLFFMRLPQ FAEERSDTML QKRFTIGDAA SGATQEKLKR KTVAQAQTAP 240
  241 RKSSAVEEPP QTPQSANLTV PGHLKAPILA TTPASPAGNI LDMQGKITQT PTTTASTGED 300
  301 ETTVPETPVI QVESTESEPL LDGETGEATS TLAEANSSEY INSVGVRFTQ QSTDHDVTSL 360
  361 SPYGLPFIQE LFRFLIILCN PLDKQNSDSM MHTGLSLLTV AFEVAADNIG KYEGLLELVK 420
  421 DDLCRNLISL LSSERLSIFA ADLQLCFLLF ESLRGHLKFQ LEAYLRKLSE IIASDNPKTP 480
  481 YEMRELALDN LLQLWRIPGF VTELYINYDC DLYCTDMFES LTNLLSKYTL SATNAVYSTH 540
  541 IISMDTLLSV IDSIERNCAA SKNSSNNRES LPEAA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.14
Match: 1m5nS
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 3.54751411727402 bayes_pls_golite062009
binding 2.38363524631144 bayes_pls_golite062009
transporter activity 2.3766833486706 bayes_pls_golite062009
substrate-specific transporter activity 1.87445049214426 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
clathrin binding 1.81128105854389 bayes_pls_golite062009
protein transmembrane transporter activity 1.29496918547173 bayes_pls_golite062009
transmembrane transporter activity 1.2724388835449 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.80477645195818 bayes_pls_golite062009
active transmembrane transporter activity 0.260663498540354 bayes_pls_golite062009
primary active transmembrane transporter activity 0.0128158555898987 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.00672548245940896 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [576-855] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PATGGSRHSR HNSGLEGIVI DSGNSVAAEE KVENIASFIN ASSHRLRLQS GGEGVGITSE  60
   61 QLAKVKQKKR LLSQGTERFN QRPEKGIQYL QEHGILNAEL DPMQVALFLR ENPGLDKKMI 120
  121 GEYISKKKNV DSKILINFVD SFDFTGLRVD QALRLYLETF RLPGEAPLIF LVLEHFSDHW 180
  181 HKQNQDPFAN VDAAFRLAYA IIMLNMDQHN SNAKRLNVPM TLEDFTKNLR GLNGGEDFDQ 240
  241 EMLAQVFNAI KNEEIVMPAE QTGLVRENYQ WKVLLRRGDT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.0
Match: 1r8mE
Description: SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO WITH BREFELDIN A-SENSITIZING MUTATIONS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ARF guanyl-nucleotide exchange factor activity 6.57705646633597 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.16463533550388 bayes_pls_golite062009
GTPase regulator activity 2.14281327181824 bayes_pls_golite062009
small GTPase regulator activity 2.10666233446144 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.03073529575688 bayes_pls_golite062009
enzyme regulator activity 1.95578809138334 bayes_pls_golite062009
binding 1.3334812784277 bayes_pls_golite062009
protein binding 0.917306986228715 bayes_pls_golite062009
phosphoinositide binding 0.0750646331148792 bayes_pls_golite062009
phospholipid binding 0.0172309833091902 bayes_pls_golite062009
cytoskeletal protein binding 0.00476738027966683 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [856-933] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDGHFHYVHD ASYDVEIFNI VWGASLSALS FMFDKSTETG YQRTLAGFSK SAAISAHYNL  60
   61 HSDFDALVLT LCKFTTLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.39794
Match: 1u27A
Description: Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,3,4,5)P4
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [934-1604] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSVEQHEPAP ANNETQQAVN FGLNGKAQAA MRTVFLLVHD YGDCLRESWK HILDLYLQLF  60
   61 RLKLLPKSLI EVEDFCEANG KAMLILEKPR EKQESGLFSS LYSFISSEGQ REPTYEEQDF 120
  121 IKLGRKCIKE CQLDQMLQES KFVQLESLQE LLKCVLALLK APQGHKSIGL PYAEDQTVFW 180
  181 MEFLVKIVVH NRDRMIPLWP AVRDQMYLLL MGSASCGYDY LLNRCIVAVL KLAIYLMRNE 240
  241 ELCPIVLQSL KMLLMLKPAL LLRISKQISI GIYELLKTSA QNIHSEQDWQ IIFNLLECVG 300
  301 AGAVPPNYDD AQLPLPPNGS AKSDGAISGE EDATAVPERG YTSDSEITKA SAAPAVSSPS 360
  361 AENWILVNNK DSELTTASRP QSPPSLSAPP VNTLVYNCQL LDHAPFALFK CWDSLAFIVR 420
  421 SVAHITPYNF EACVRCIRIF VEACRDGGIR QRRKLESAAK QKSSKKRSER KPGMASSASS 480
  481 SNLTLLTGDP SDNQINGNAA EQEDLAQRYE QLSIQLLDLM YTLYTRTAQI FRWWAEEGCT 540
  541 VPQSAALWSP GWCPLLQGIA RLAMDRRREV RTHAISCLQQ RALLVHDLQT LSGTEWCSCF 600
  601 HQVLFPLLNE LLPESNAAGQ LDAALLEESR IRTATIMSKV FLQHLTTLIE LGNAFNELWL 660
  661 DILDYIERFM K

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.989
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 3.54751411727402 bayes_pls_golite062009
binding 2.38363524631144 bayes_pls_golite062009
transporter activity 2.3766833486706 bayes_pls_golite062009
substrate-specific transporter activity 1.87445049214426 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
clathrin binding 1.81128105854389 bayes_pls_golite062009
protein transmembrane transporter activity 1.29496918547173 bayes_pls_golite062009
transmembrane transporter activity 1.2724388835449 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.80477645195818 bayes_pls_golite062009
active transmembrane transporter activity 0.260663498540354 bayes_pls_golite062009
primary active transmembrane transporter activity 0.0128158555898987 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.00672548245940896 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1605-1983] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGSDTLSEQM QEILKNMLLV MHSVRVFHNQ DGSLQQALWE LTWRRIGEFL PNLKEELFHD  60
   61 EGKRAQTLTN PAPQAAVAAA PQQQLPAVTI LPRQTQVSNE LVVSAPTPPA ATPLLGSPVE 120
  121 SPRRSIILQP PMADVLQQPP SFVFAQPIIV PPQPPAVTDP IPPSTLLPDL VNEATAAAVQ 180
  181 ATTTSPTHSP QEAEQPASIV QQTNIVTTNN TYNSYAIEVP MAPETTAEQF GQQQQQLLYQ 240
  241 QYYQQYQAQQ QQLPAPASDP AINVPISHLL AGNAYPSLPK MPQASIVHSF APVYESQAAT 300
  301 SGAGTAAADI YQEYVQNPYN LTLQQHPQQQ LHQQQQQQQQ QATGMANAFP AVATPANYFN 360
  361 VNVDPSSIPP GSELLYGQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.154902
Match: 1y0fA
Description: No description for 1y0fA was found.
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