Protein Overview: garz-PA

General Information:
Name(s) found:	garz-PA / FBpp0087011 [FlyBase]
Description(s) found: Found 20 descriptions. SHOW ALL	The gene gartenzwerg is referred to in FlyBase by the symbol Dmel\garz (CG8487, FBgn0033714). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8214179..8221327. It has the cytological map location 48F8-48F10. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: phagocytosis, engulfment. 3 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; eye; intersegmental nerve; eye photoreceptor cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1740 amino acids
Gene Ontology:
Cellular Component:	Golgi-associated vesicle [ISS]
Biological Process:	ER to Golgi vesicle-mediated transport [ISS] phagocytosis, engulfment [IMP] intra-Golgi vesicle-mediated transport [ISS] regulation of ARF protein signal transduction [IEA]
Molecular Function:	ARF guanyl-nucleotide exchange factor activity [IEA] guanyl-nucleotide exchange factor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALPGNGIYV VRGEMATLMT AMRRGTRWNA TAYVDDENDS LLKLFIDLKH ELNRIEDLRQ  60
   61 IEPQVFLAPF LEVIRTADAT GPLTSLALAS VNKLLSYGLI DPTSPNLADI VERIADAVTH 120
  121 ARFMGTDQSS DGVTFMRVIE VLHTLIRSPE GAAVSNVSMC EVMLSCFKIS FEPRLSELLR 180
  181 RSAEKSLKDM VLLFFMRLPQ FAEERSDTML QKRFTIGDAA SGATQEKLKR KTVAQAQTAP 240
  241 RKSSAVEEPP QTPQSANLTV PGHLKAPILA TTPASPAGNI LDMQGKITQT PTTTASTGED 300
  301 ETTVPETPVI QVESTESEPL LDGETGEATS TLAEANSSEY INSVGVRFTQ QSTDHDVTSL 360
  361 SPYGLPFIQE LFRFLIILCN PLDKQNSDSM MHTGLSLLTV AFEVAADNIG KYEGLLELVK 420
  421 DDLCRNLISL LSSERLSIFA ADLQLCFLLF ESLRGHLKFQ LEAYLRKLSE IIASDNPKTP 480
  481 YEMRELALDN LLQLWRIPGF VTELYINYDC DLYCTDMFES LTNLLSKYTL SATNAVYSTH 540
  541 IISMDTLLSV IDSIERNCAA SKNSSNNRES LPEAAPATGG SRHSRHNSGL EGIVIDSGNS 600
  601 VAAEEKVENI ASFINASSHR LRLQSGGEGV GITSEQLAKV KQKKRLLSQG TERFNQRPEK 660
  661 GIQYLQEHGI LNAELDPMQV ALFLRENPGL DKKMIGEYIS KKKNVDSKIL INFVDSFDFT 720
  721 GLRVDQALRL YLETFRLPGE APLIFLVLEH FSDHWHKQNQ DPFANVDAAF RLAYAIIMLN 780
  781 MDQHNSNAKR LNVPMTLEDF TKNLRGLNGG EDFDQEMLAQ VFNAIKNEEI VMPAEQTGLV 840
  841 RENYQWKVLL RRGDTHDGHF HYVHDASYDV EIFNIVWGAS LSALSFMFDK STETGYQRTL 900
  901 AGFSKSAAIS AHYNLHSDFD ALVLTLCKFT TLLSSVEQHE PAPANNETQQ AVNFGLNGKA 960
  961 QAAMRTVFLL VHDYGDCLRE SWKHILDLYL QLFRLKLLPK SLIEVEDFCE ANGKAMLILE1020
 1021 KPREKQESGL FSSLYSFISS EGQREPTYEE QDFIKLGRKC IKECQLDQML QESKFVQLES1080
 1081 LQELLKCVLA LLKAPQGHKS IGLPYAEDQT VFWMEFLVKI VVHNRDRMIP LWPAVRDQMY1140
 1141 LLLMGSASCG YDYLLNRCIV AVLKLAIYLM RNEELCPIVL QSLKMLLMLK PALLLRISKQ1200
 1201 ISIGIYELLK TSAQNIHSEQ DWQIIFNLLE CVGAGAVPPN YDDAQLPLPP NGSAKSDGAI1260
 1261 SGEEDATAVP ERGYTSDSEI TKASAAPAVS SPSAENWILV NNKDSELTTA SRPQSPPSLS1320
 1321 APPVNTLVYN CQLLDHAPFA LFKCWDSLAF IVRSVAHITP YNFEACVRCI RIFVEACRDG1380
 1381 GIRQRRKLES AAKQKSSKKR SERKPGMASS ASSSNLTLLT GDPSDNQING NAAEQEDLAQ1440
 1441 RYEQLSIQLL DLMYTLYTRT AQIFRWWAEE GCTVPQSAAL WSPGWCPLLQ GIARLAMDRR1500
 1501 REVRTHAISC LQQRALLVHD LQTLSGTEWC SCFHQVLFPL LNELLPESNA AGQLDAALLE1560
 1561 ESRIRTATIM SKVFLQHLTT LIELGNAFNE LWLDILDYIE RFMKVGSDTL SEQMQEILKN1620
 1621 MLLVMHSVRV FHNQDGSLQQ ALWELTWRRI GEFLPNLKEE LFHDEDSITP AVSLDYTQIR1680
 1681 FAHSTGTTDY SLSLPLYGYS PKISSISASK CDTLPATQRK KPWAKLRSKL KLLKKVGKKN1740
 1741

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
protein transporter activity	3.54751411727402	bayes_pls_golite062009
binding	2.38363524631144	bayes_pls_golite062009
transporter activity	2.3766833486706	bayes_pls_golite062009
substrate-specific transporter activity	1.87445049214426	bayes_pls_golite062009
protein binding	1.81870125631028	bayes_pls_golite062009
clathrin binding	1.81128105854389	bayes_pls_golite062009
protein transmembrane transporter activity	1.29496918547173	bayes_pls_golite062009
transmembrane transporter activity	1.2724388835449	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.80477645195818	bayes_pls_golite062009
active transmembrane transporter activity	0.260663498540354	bayes_pls_golite062009
primary active transmembrane transporter activity	0.0128158555898987	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.00672548245940896	bayes_pls_golite062009

Term	Confidence	Notes
ARF guanyl-nucleotide exchange factor activity	6.57705646633597	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.16463533550388	bayes_pls_golite062009
GTPase regulator activity	2.14281327181824	bayes_pls_golite062009
small GTPase regulator activity	2.10666233446144	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	2.03073529575688	bayes_pls_golite062009
enzyme regulator activity	1.95578809138334	bayes_pls_golite062009
binding	1.3334812784277	bayes_pls_golite062009
protein binding	0.917306986228715	bayes_pls_golite062009
phosphoinositide binding	0.0750646331148792	bayes_pls_golite062009
phospholipid binding	0.0172309833091902	bayes_pls_golite062009
cytoskeletal protein binding	0.00476738027966683	bayes_pls_golite062009

Term	Confidence	Notes
protein transporter activity	3.54751411727402	bayes_pls_golite062009
binding	2.38363524631144	bayes_pls_golite062009
transporter activity	2.3766833486706	bayes_pls_golite062009
substrate-specific transporter activity	1.87445049214426	bayes_pls_golite062009
protein binding	1.81870125631028	bayes_pls_golite062009
clathrin binding	1.81128105854389	bayes_pls_golite062009
protein transmembrane transporter activity	1.29496918547173	bayes_pls_golite062009
transmembrane transporter activity	1.2724388835449	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.80477645195818	bayes_pls_golite062009
active transmembrane transporter activity	0.260663498540354	bayes_pls_golite062009
primary active transmembrane transporter activity	0.0128158555898987	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.00672548245940896	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..571]	FFAS03	1.14	Importin beta
2	View Details	[572..856]	PSI-BLAST	62.045757	SEC7 DOMAIN OF THE ARF EXCHANGE FACTOR ARNO WITH BREFELDIN A-SENSITIZING MUTATIONS
3	View Details	[857..1635]	FFAS03	1.26	No description for 2ie3A was found.
4	View Details	[1636..1740]	FFAS03	0.953	Adaptin beta subunit N-terminal fragment

Protein Overview: garz-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: