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View Structure Prediction Details

Protein: rnh1-PA
Organism: Drosophila melanogaster
Length: 333 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rnh1-PA.

Description E-value Query
Range
Subject
Range
gi|2677845, gi|7... - pir||JC5787 ribonuclease H (EC 3.1.26.4) 1 - fruit fly (Drosophila melanogaster), gi|2677845|gb|AAC...
269.0 [0..1] [333..1]

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Predicted Domain #1
Region A:
Residues: [1-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLPRYFCWN LQRCTMAFYA VASGRRSGVY GSWAECEEQV KGFKNAKYKK FKTRQEADQF  60
   61 VNGCKSYAPQ DVAVPLGKEK ASLASWKNSI EVNKNPKYTD EWPEEDHDLA EDDLNAAMNE 120
  121 VEGDPKPSNS SNLPDILNRK RKGTTSGDKR NKIPRHASQV SEATGLKQVG AFQFE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.30103
Match: 2iajB
Description: No description for 2iajB was found.

Predicted Domain #2
Region A:
Residues: [176-333]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDAEGYVIVY TDGSCIGNGR AGACAGYGVY FGKNHQLNAA KPVEGRVTNN VGEIQAAIHA  60
   61 IKTALDLGIQ KLCISTDSQF LINSITLWVA GWKKRDWKLK NNQPVKNVVD FKELDKLLQE 120
  121 NNITVKWNYV EAHKGIEGNE MADKLARQGS ALYKQKNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.045757
Match: 1rbrA
Description: STRUCTURAL STUDY OF MUTANTS OF ESCHERICHIA COLI RIBONUCLEASE HI WITH ENHANCED THERMOSTABILITY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease activity 4.81599779544001 bayes_pls_golite062009
exoribonuclease activity 3.01417328311605 bayes_pls_golite062009
ribonuclease H activity 2.91966688044755 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 2.89077854960958 bayes_pls_golite062009
exonuclease activity 2.69024175413643 bayes_pls_golite062009
nuclease activity 2.65398446409354 bayes_pls_golite062009
endonuclease activity 2.63074055051349 bayes_pls_golite062009
endoribonuclease activity 2.59247838057313 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.57498413015114 bayes_pls_golite062009
3'-5'-exoribonuclease activity 2.49957333962564 bayes_pls_golite062009
hydrolase activity 2.41899414621161 bayes_pls_golite062009
DNA polymerase activity 1.82615627615268 bayes_pls_golite062009
DNA-directed DNA polymerase activity 1.68530265026203 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.61250137150057 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
binding 1.20709976964365 bayes_pls_golite062009
nucleic acid binding 1.12235348738959 bayes_pls_golite062009
deoxyribonuclease activity 1.1219517187744 bayes_pls_golite062009
transcription regulator activity 1.10433412699603 bayes_pls_golite062009
3'-5' exonuclease activity 0.86862629020506 bayes_pls_golite062009
DNA binding 0.710663468386339 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
nucleotidyltransferase activity 0.623018247078448 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
transcription factor activity 0.332903382446869 bayes_pls_golite062009
exodeoxyribonuclease activity 0.278838342302102 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.261428436029202 bayes_pls_golite062009
protein binding 0.242714557118293 bayes_pls_golite062009

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