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View Structure Prediction Details

Protein: pk-PC
Organism: Drosophila melanogaster
Length: 1299 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pk-PC.

Description E-value Query
Range
Subject
Range
gi|73948425 - gi|73948425|ref|XP_541659.2| PREDICTED: similar to zinc finger protein 91 (HPF7, HTF10) [Canis famil...
756.0 [0..346] [1140..343]

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Predicted Domain #1
Region A:
Residues: [1-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLSTGGGA GGSSGGPGGA DAAAAPAAGQ ATVTATGNME PAMVPRTANL LACKQWWRVC  60
   61 FLYGDQQKYY RQLYSKAAAQ RLADANQEPD NARDREYDTV DCDLIAGQLD AVEDADDGID 120
  121 LGDHSSTPKG GATTAGRPLF PHSSSPRRSK KLLRSLRAHV RGEKLPKNDT TTANESSEVT 180
  181 QRNARVTVLD DPFLFGIDAD HLGDLVVRGK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [211-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYSTLDATEN MARFYAEQEA TAQVLEIIEQ EEESPEQEAP KPALPPKQKQ QRPVPPLPPP  60
   61 PANRVTQDQG TQPAAPQVPL QPLTAGDLQF LNLSLRQRSL PRSMKPFKDA HDISFTFNEL 120
  121 DTSAEPEVAT GAAQQESNEP ISRTPLTQIS YLQKIPTLPR HFSPSGQGLA TPPALGSGGM 180
  181 GLPSSSSASA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [401-480]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYAAQAAAGI LPTSPLPLQR HQQYLPPHHQ QHPGAGMGPG PGSGAAAGPP LGPQYSPGCS  60
   61 ANPKYSNAQL PPPPHHHHQL 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [481-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPALSTPSPP SLLHHPAGGT SSASAHAPFL GGPHMDMQRQ SHSDDDSGCA LEEYTWVPPG  60
   61 LRPDQVRLYF SQIPDDKV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.30103
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.26906680202757 bayes_pls_golite062009
nucleic acid binding 1.5361877165154 bayes_pls_golite062009
DNA binding 1.50805568602414 bayes_pls_golite062009
protein binding 0.905022998164426 bayes_pls_golite062009
transcription factor activity 0.594688838246446 bayes_pls_golite062009
signal transducer activity 0.0590340677124848 bayes_pls_golite062009
molecular transducer activity 0.0590340677124848 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [559-746]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYVNSPGEQY RVRQLLHQLP PHDNEVRYCH SLTDEERKEL RLFSTQRKRD ALGRGNVRQL  60
   61 MSARPCDGCD DLISTGDIAV FATRLGPNAS WHPACFACSV CRELLVDLIY FHRDGRMYCG 120
  121 RHHAETLKPR CSACDEIILA DECTEAEGRA WHMNHFACHE CDKQLGGQRY IMREGKPYCL 180
  181 HCFDAMFA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.0
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #6
Region A:
Residues: [747-826]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYCDYCGEAI GVDQGQMSHD GQHWHATDEC FSCNTCRCSL LGRAFLPRRG AIYCSIACSK  60
   61 GEPPTPSDSS GTGMYTTPTP 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.7
Match: 2cupA
Description: Solution structure of the Skeletal muscle LIM-protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.0300494058962 bayes_pls_golite062009
protein binding 1.20339329058617 bayes_pls_golite062009
receptor activity 1.00000843633623 bayes_pls_golite062009
transporter activity 0.893102092384062 bayes_pls_golite062009
signal transducer activity 0.73994900849782 bayes_pls_golite062009
molecular transducer activity 0.73994900849782 bayes_pls_golite062009
transmembrane transporter activity 0.7072042577999 bayes_pls_golite062009
substrate-specific transporter activity 0.489535882040485 bayes_pls_golite062009
DNA binding 0.397111874492592 bayes_pls_golite062009
nucleic acid binding 0.297808510495986 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.256518766904171 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [827-975]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTQRVRPHPQ APLPARIPSS HASSSPPMSP QQQQQHQATF NQAMYQMQSQ QMEAAGGLVD  60
   61 QSKSYAASDS DAGVVKDLEH GGHMGGGDLT DFSGGRASST SQNLSPLNSP GDFQPHFLPK 120
  121 PMELQRDGVY NFNEMSSNLD AAWSAKPTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 1ubdC
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [976-1087]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYHLQRQLLE NPHTASMPEL AGKLVAPPAH MQHLSQLHAV SSHQFQQHEY ADILHPPPPP  60
   61 PGEIPELPTP NLSVASTALP PELMGSPTHS AGDRSLNTPM STQSASHAPP HP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1088-1299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSILSGASSS SPMSGEPAKK KGVRFEGIPD TLPRSRSYSG NGAGTSGGGE RERDRDKDKE  60
   61 GGGRHGHGHS SRRRRRRKSS SSSSHHRSGS GHRSHSTTRA DTYAPAQPLS SSYQGPPSVL 120
  121 QAANLVHESP SRQQRERERE REREESEESD VCSTCSSSSS SSEDYMMMYQ LPQRRHYGGV 180
  181 RVSYVPNDAL AYDRKRKPSE LGGDKDKNCI IS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle