YRC Public Data Repository - Protein Structure Prediction

Protein:	THIO_RAT
Organism:	Rattus norvegicus
Length:	105 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THIO_RAT.

Description	E-value	Query Range	Subject Range
gi\|114626146 - gi\|114626146\|ref\|XP_001142154.1\| PREDICTED: similar to Thioredoxin (ATL-derived factor) (ADF) (Surfa...	147.0	[0..1]	[104..219]
gi\|53801490 - gi\|53801490\|gb\|AAU93947.1\| thioredoxin H [Helicosporidium sp. ex Simulium jonesii]	139.0	[0..2]	[105..5]
gi\|49076440, gi\|... - gi\|71020991\|ref\|XP_760726.1\| hypothetical protein UM04579.1 [Ustilago maydis 521], ref\|XP_402194.1\| ...	138.0	[0..1]	[105..1]
gi\|160872103, gi... - gi\|94494048\|ref\|ZP_01301251.1\| hypothetical protein Rgryl_01000578 [Rickettsiella grylli], gi\|160872...	136.0	[0..3]	[104..6]
gi\|67473772, gi\|... - gi\|67473772\|ref\|XP_652635.1\| thioredoxin [Entamoeba histolytica HM-1:IMSS], gi\|56469506\|gb\|EAL47249....	136.0	[0..2]	[100..3]
THIO_MACMU - Thioredoxin OS=Macaca mulatta GN=TXN PE=3 SV=2	135.0	[0..1]	[104..1]
gi\|73971948 - gi\|73971948\|ref\|XP_532029.2\| PREDICTED: similar to Thioredoxin (ATL-derived factor) (ADF) (Surface a...	134.0	[0..11]	[104..125]
gi\|157830999, gi... - gi\|1827675\|pdb\|1ERV\| Chain , Human Thioredoxin Mutant With Cys 73 Replaced By Ser (Reduced Form), ...	134.0	[0..1]	[104..1]
gi\|76812139, gi\|... - gi\|76812139\|ref\|YP_333769.1\| thioredoxin 1 [Burkholderia pseudomallei 1710b], gi\|76581592\|gb\|ABA5106...	134.0	[0..1]	[104..39]

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Predicted Domain #1

Region A:
Residues: [1-105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKLIESKEA FQEALAAAGD KLVVVDFSAT WCGPCKMIKP FFHSLCDKYS NVVFLEVDVD  60
   61 DCQDVAADCE VKCMPTFQFY KKGQKVGEFS GANKEKLEAT ITEFA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.30103
Match:	1ervA
Description:	HUMAN THIOREDOXIN MUTANT WITH CYS 73 REPLACED BY SER (REDUCED FORM)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	3.8464796631544	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.23310780102446	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
selenium binding	1.97148144306198	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.47769936616412	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
transcription regulator activity	0.96297634785608	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
hydrolase activity	0.620302638089385	bayes_pls_golite062009
glutathione binding	0.2456976890622	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: