YRC Public Data Repository - Protein Structure Prediction

Protein:	PTPS_RAT
Organism:	Rattus norvegicus
Length:	144 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTPS_RAT.

Description	E-value	Query Range	Subject Range
gi\|78213852, gi\|... - gi\|78213852\|ref\|YP_382631.1\| 6-pyruvoyltetrahydropterin synthase [Synechococcus sp. CC9605], gi\|7819...	186.0	[0..3]	[144..146]
gi\|109108666 - gi\|109108666\|ref\|XP_001108264.1\| PREDICTED: 6-pyruvoyltetrahydropterin synthase [Macaca mulatta]	185.0	[0..6]	[144..7]
gi\|114640356 - gi\|114640356\|ref\|XP_001147929.1\| PREDICTED: 6-pyruvoyltetrahydropterin synthase [Pan troglodytes]	182.0	[0..6]	[144..7]
PTPS_PONAB - 6-pyruvoyl tetrahydrobiopterin synthase OS=Pongo abelii GN=PTS PE=2 SV=1 PTPS_PONPY - 6-pyruvoyl tetrahydrobiopterin synthase - Pongo pygmaeus (Orangutan)	181.0	[0..6]	[144..7]
gi\|165377310, gi... - gi\|76635142\|ref\|XP_583363.2\| PREDICTED: similar to 6-pyruvoyl tetrahydrobiopterin synthase precursor...	181.0	[0..1]	[144..1]
gi\|116071454, gi... - gi\|116071454\|ref\|ZP_01468722.1\| 6-pyruvoyltetrahydropterin synthase [Synechococcus sp. BL107], gi\|11...	181.0	[0..3]	[144..84]
gi\|117645424, gi... - gi\|123994915\|gb\|ABM85059.1\| 6-pyruvoyltetrahydropterin synthase [synthetic construct], gi\|123980116\|... PTS - 6-pyruvoyltetrahydropterin synthase	181.0	[0..6]	[144..7]
gi\|116069197, gi... - gi\|116073892\|ref\|ZP_01471154.1\| 6-pyruvoyltetrahydropterin synthase [Synechococcus sp. RS9916], gi\|1...	181.0	[0..3]	[144..147]
PTPS_POERE - 6-pyruvoyl tetrahydrobiopterin synthase OS=Poecilia reticulata GN=pts PE=2 SV=1	180.0	[0..1]	[144..1]

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Predicted Domain #1

Region A:
Residues: [1-144]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNAAVGLRRR ARLSRLVSFS ASHRLHSPSL SAEENLKVFG KCNNPNGHGH NYKVVVTIHG  60
   61 EIDPVTGMVM NLTDLKEYME EAIMKPLDHK NLDLDVPYFA DVVSTTENVA VYIWENLQRL 120
  121 LPVGALYKVK VYETDNNIVV YKGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.154902
Match:	1b66A
Description:	6-pyruvoyl tetrahydropterin synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	4.1430878480831	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.94513271787536	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
dihydroneopterin aldolase activity	1.96466418682643	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: