YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|123993025, gi...
Organism:	synthetic construct
Length:	354 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123993025, gi....

Description	E-value	Query Range	Subject Range
gi\|114657504, gi... - gi\|114657504\|ref\|XP_001173904.1\| PREDICTED: carbonic anhydrase XII isoform 7 [Pan troglodytes], gi\|1...	0.0	[1..354]	[1..354]
gi\|109081435 - gi\|109081435\|ref\|XP_001105437.1\| PREDICTED: similar to carbonic anhydrase XII isoform 1 precursor is...	0.0	[1..354]	[1..354]
gi\|30585185, gi\|... - gi\|61372438\|gb\|AAX43843.1\| carbonic anhydrase XII [synthetic construct], gi\|30585185\|gb\|AAP36865.1\| ...	0.0	[1..354]	[1..343]
gi\|119598056, gi... - gi\|45935383\|ref\|NP_996808.1\| carbonic anhydrase XII isoform 2 precursor [Homo sapiens], gi\|30582151\|... gi\|60655349 - gi\|60655349\|gb\|AAX32238.1\| carbonic anhydrase XII [synthetic construct]	0.0	[1..354]	[1..343]
CAH12_RABIT - Carbonic anhydrase 12 OS=Oryctolagus cuniculus GN=CA12 PE=2 SV=2	0.0	[1..354]	[1..355]
CAH12_MOUSE - Carbonic anhydrase 12 OS=Mus musculus GN=Ca12 PE=1 SV=1	0.0	[1..354]	[1..354]

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Predicted Domain #1

Region A:
Residues: [1-354]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL  60
   61 HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL 120
  121 HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN 180
  181 PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR 240
  241 NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL 300
  301 SLGIILSLAL AGILGICIVV VVSIWLFRRK SIKKGDNKGV IYKPATKMET EAHA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.0
Match:	1jczA
Description:	Carbonic anhydrase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbonate dehydratase activity	2.35405414226159	bayes_pls_golite062009
binding	1.59667704693142	bayes_pls_golite062009
protein binding	1.30419076438266	bayes_pls_golite062009
catalytic activity	0.97285738666961	bayes_pls_golite062009
zinc ion binding	0.744428270762821	bayes_pls_golite062009
transition metal ion binding	0.36067052386032	bayes_pls_golite062009
carbon-oxygen lyase activity	0.0641135521348118	bayes_pls_golite062009
hydro-lyase activity	0.0479238316186823	bayes_pls_golite062009
lyase activity	0.0337150119314038	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: