YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|117616406
Organism:	synthetic construct
Length:	217 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|117616406.

Description	E-value	Query Range	Subject Range
gi\|60825179, gi\|... - gi\|61365696\|gb\|AAX42748.1\| growth factor receptor-bound protein 2 [synthetic construct], gi\|61365122...	161.0	[0..1]	[217..1]
gi\|212549621, gi... - gi\|212549621\|ref\|NP_001131100.1\| growth factor receptor-bound protein 2 [Sus scrofa], gi\|208612619\|g... GRB2_RAT - Growth factor receptor-bound protein 2 OS=Rattus norvegicus GN=Grb2 PE=1 SV=1 gi\|149723303 - gi\|149723303\|ref\|XP_001495816.1\| PREDICTED: similar to growth factor receptor-bound protein 2 isofor... HGNC:4566\|MIM:10... - factor receptor-bound protein 2 GRB2_PONPY - Growth factor receptor-bound protein 2 - Pongo pygmaeus (Orangutan) tr\|G3GTE4\|G3GTE4... - Growth factor receptor-bound protein 2 OS=Cricetulus griseus GN=I79_000924 PE=4 SV=1 gi\|114670447, gi... - gi\|114670453\|ref\|XP_001141640.1\| PREDICTED: similar to ash protein isoform 7 [Pan troglodytes], gi\|1... ENSCJAT00000028010 - null GRB2 - growth factor receptor-bound protein 2 gi\|77736207, gi\|... - gi\|77736207\|ref\|NP_001029802.1\| growth factor receptor-bound protein 2 [Bos taurus], gi\|74354609\|gb\|... tr\|M3XAW3\|M3XAW3... - Growth factor receptor bound protein 2 OS=Felis catus GN=GRB2 PE=4 SV=1 gi\|73964904, gi\|... - gi\|73964906\|ref\|XP_859067.1\| PREDICTED: similar to Growth factor receptor-bound protein 2 (GRB2 adap... gi\|84579023, gi\|... - gi\|90075372\|dbj\|BAE87366.1\| unnamed protein product [Macaca fascicularis], gi\|84579023\|dbj\|BAE72945.... CCDS11721.1_1 - null ENSOCUP000000055... - pep:novel scaffold:oryCun2:GL018845:344108:420891:1 gene:ENSOCUG00000006469 transcript:ENSOCUT000000... GRB2_PONAB - Growth factor receptor-bound protein 2 OS=Pongo abelii GN=GRB2 PE=2 SV=1 gi\|123981854, gi... - gi\|61354967\|gb\|AAX41082.1\| growth factor receptor-bound protein 2 [synthetic construct], gi\|60812942...	160.0	[0..1]	[217..1]
gi\|74214845 - gi\|74214845\|dbj\|BAE33439.1\| unnamed protein product [Mus musculus]	160.0	[0..1]	[217..1]
gi\|54261769, gi\|... - gi\|54261769\|ref\|NP_998200.1\| growth factor receptor-bound protein 2 [Danio rerio], gi\|37590325\|gb\|AA...	159.0	[0..1]	[216..1]
GRB2_CHICK - Growth factor receptor-bound protein 2 OS=Gallus gallus GN=GRB2 PE=1 SV=1	159.0	[0..1]	[217..1]
GRB2_XENLA - (P87379) Growth factor receptor-bound protein 2 (GRB2 adapter protein) (SH2/SH3 adapter GRB2)	156.0	[0..1]	[216..1]
GRB2_XENTR - Growth factor receptor-bound protein 2 OS=Xenopus tropicalis GN=grb2 PE=2 SV=1	152.0	[0..1]	[216..1]

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Predicted Domain #1

Region A:
Residues: [1-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW  60
   61 FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120
  121 WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQMPQQPTY VQALFDFDPQ EDGELGFRRG 180
  181 DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.69897
Match:	1griA
Description:	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
molecular transducer activity	3.13508395312263	bayes_pls_golite062009
signal transducer activity	3.13508395312263	bayes_pls_golite062009
epidermal growth factor receptor binding	2.9751846707539	bayes_pls_golite062009
binding	2.69791297400248	bayes_pls_golite062009
cytoskeletal protein binding	2.57554390739461	bayes_pls_golite062009
actin binding	2.17709619225063	bayes_pls_golite062009
protein binding	2.14586566310919	bayes_pls_golite062009
insulin receptor binding	2.1238568876176	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.85015570449703	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
receptor binding	1.80554013976158	bayes_pls_golite062009
kinase activity	1.78069536883109	bayes_pls_golite062009
protein kinase activity	1.64363774024605	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.59739467025045	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
transferase activity	1.19152443245584	bayes_pls_golite062009
actin filament binding	1.03574214978228	bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity	1.03150090191995	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.950445630788802	bayes_pls_golite062009
transporter activity	0.896907103596953	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
transcription regulator activity	0.786324379459923	bayes_pls_golite062009
transmembrane transporter activity	0.713068405985864	bayes_pls_golite062009
nucleic acid binding	0.696368655705791	bayes_pls_golite062009
protein complex binding	0.65988681496356	bayes_pls_golite062009
protein phosphorylated amino acid binding	0.649814096718101	bayes_pls_golite062009
DNA binding	0.578730664467311	bayes_pls_golite062009
enzyme regulator activity	0.456661966897198	bayes_pls_golite062009
sevenless binding	0.418968910155118	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
insulin receptor substrate binding	0.29798436765753	bayes_pls_golite062009
substrate-specific transporter activity	0.245869952317152	bayes_pls_golite062009
structural molecule activity	0.236653863910566	bayes_pls_golite062009
protein tyrosine kinase activity	0.206747304356052	bayes_pls_golite062009
phosphoprotein binding	0.16798254471727	bayes_pls_golite062009
kinase binding	0.131981353175621	bayes_pls_golite062009
receptor signaling protein activity	0.0443241110585009	bayes_pls_golite062009
transcription factor activity	0.0291114923524518	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.0273219613963591	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: