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View Structure Prediction Details

Protein: PR2C2_MOUSE
Organism: Mus musculus
Length: 224 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PR2C2_MOUSE.

Description E-value Query
Range
Subject
Range
PRL_PIG - Prolactin OS=Sus scrofa GN=PRL PE=1 SV=3
277.0 [0..6] [224..7]
PRL_AILME - Prolactin OS=Ailuropoda melanoleuca GN=PRL PE=2 SV=1
265.0 [0..24] [224..25]
PRL_NEOVI - Prolactin OS=Neovison vison GN=PRL PE=2 SV=3
PRL_MUSVI - Prolactin precursor (PRL) - Mustela vison (American mink)
265.0 [0..24] [224..25]
gi|74004132 - gi|74004132|ref|XP_545363.2| PREDICTED: similar to Prolactin precursor (PRL) [Canis familiaris]
265.0 [0..24] [224..55]
PRL_FELCA - Prolactin OS=Felis catus GN=PRL PE=2 SV=1
264.0 [0..24] [224..25]
PRL_BOVIN - Prolactin OS=Bos taurus GN=PRL PE=1 SV=1
263.0 [0..6] [224..7]
PRL_RABIT - Prolactin OS=Oryctolagus cuniculus GN=PRL PE=2 SV=1
262.0 [0..24] [224..23]
PRL_SHEEP - Prolactin OS=Ovis aries GN=PRL PE=1 SV=2
262.0 [0..7] [224..8]
PRL_CEREL - Prolactin OS=Cervus elaphus GN=PRL PE=2 SV=1
262.0 [0..6] [224..7]

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Predicted Domain #1
Region A:
Residues: [1-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPSLIQPCS WILLLLLVNS SLLWKNVASF PMCAMRNGRC FMSFEDTFEL AGSLSHNISI  60
   61 EVSELFTEFE KHYSNVSGLR DKSPMRCNTS FLPTPENKEQ ARLTHYSALL KSGAMILDAW 120
  121 ESPLDDLVSE LSTIKNVPDI IISKATDIKK KINAVRNGVN ALMSTMLQNG DEEKKNPAWF 180
  181 LQSDNEDARI HSLYGMISCL DNDFKKVDIY LNVLKCYMLK IDNC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.522879
Match: 1n9dA
Description: Prolactin (placental lactogen)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
cytokine activity 5.1883241815362 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
prolactin receptor binding 4.15199297607294 bayes_pls_golite062009
protein binding 3.52041127390038 bayes_pls_golite062009
growth hormone activity 3.48964024373018 bayes_pls_golite062009
binding 2.95468228480505 bayes_pls_golite062009
hormone activity 2.52921243340076 bayes_pls_golite062009
transcription regulator activity 1.65758440572832 bayes_pls_golite062009
interleukin-27 binding 1.65090888783496 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 1.59946630359187 bayes_pls_golite062009
interleukin-6 receptor binding 1.35761970306312 bayes_pls_golite062009
interleukin-10 receptor binding 1.21666375770079 bayes_pls_golite062009
interferon-alpha/beta receptor binding 0.93290045827216 bayes_pls_golite062009
erythropoietin receptor binding 0.5867301437183 bayes_pls_golite062009
interleukin-12 binding 0.30601802121141 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009

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