YRC Public Data Repository - Protein Structure Prediction

Protein:	TXNL1_MOUSE
Organism:	Mus musculus
Length:	289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TXNL1_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|194690714, gi... - gi\|212722176\|ref\|NP_001131150.1\| hypothetical protein LOC100192458 [Zea mays], gi\|194690714\|gb\|ACF79... TXNL1_RAT - Thioredoxin-like protein 1 OS=Rattus norvegicus GN=Txnl1 PE=1 SV=3	278.0	[0..1]	[289..1]
gi\|61372783 - gi\|61372783\|gb\|AAX43911.1\| thioredoxin-like 1 [synthetic construct]	277.0	[0..1]	[289..1]
CCDS11961.1_1 - null gi\|109122272 - gi\|109122272\|ref\|XP_001083710.1\| PREDICTED: thioredoxin-like 1 isoform 2 [Macaca mulatta]	277.0	[0..1]	[289..1]
gi\|74212400, gi\|... - gi\|74212400\|dbj\|BAE30948.1\| unnamed protein product [Mus musculus], gi\|74181308\|dbj\|BAE29934.1\| unna...	277.0	[0..1]	[289..1]
gi\|123996717, gi... - gi\|60655503\|gb\|AAX32315.1\| thioredoxin-like 1 [synthetic construct], gi\|157928290\|gb\|ABW03441.1\| thi... TXNL1 - thioredoxin-like 1 gi\|114673269, gi... - gi\|114673269\|ref\|XP_512145.2\| PREDICTED: thioredoxin-like 1 isoform 6 [Pan troglodytes], gi\|11467326... ENSCJAT00000007739 - null	277.0	[0..1]	[289..1]
gi\|50806608 - gi\|50806608\|ref\|XP_424463.1\| PREDICTED: similar to thioredoxin-like protein [Gallus gallus]	276.0	[0..1]	[289..1]
gi\|118150882, gi... - gi\|118150882\|ref\|NP_001071354.1\| thioredoxin-like 1 [Bos taurus], gi\|113912203\|gb\|AAI22817.1\| Thiore...	276.0	[0..1]	[289..1]
gi\|182891510, gi... - gi\|41053764\|ref\|NP_957432.1\| thioredoxin-like 1 [Danio rerio], gi\|28278840\|gb\|AAH45322.1\| Thioredoxi...	274.0	[0..1]	[289..1]

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Predicted Domain #1

Region A:
Residues: [1-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK YPQAVFLEVD  60
   61 VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE EKIKQHLEND

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.09691
Match:	1gh2A
Description:	Thioredoxin-like protein, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	3.8464796631544	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	2.3913606099687	bayes_pls_golite062009
protein disulfide isomerase activity	2.3913606099687	bayes_pls_golite062009
protein-disulfide reductase activity	2.24066563461479	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.23310780102446	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	2.18667085747706	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
selenium binding	1.1082524159827	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
transcription regulator activity	0.52671047749426	bayes_pls_golite062009
protein disulfide oxidoreductase activity	0.44918717550973	bayes_pls_golite062009
transferase activity	0.245320538630117	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [111-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGSNEDADIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL RKDMSFLESD CDEQLLITVA  60
   61 FNQPVKLYSM KFQGPDNGQG PKYVKIFINL PRSMDFEEAE RSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.69897
Match:	1bjxA
Description:	HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 24 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	3.8464796631544	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	2.3913606099687	bayes_pls_golite062009
protein disulfide isomerase activity	2.3913606099687	bayes_pls_golite062009
protein-disulfide reductase activity	2.24066563461479	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.23310780102446	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	2.18667085747706	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
selenium binding	1.1082524159827	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
transcription regulator activity	0.52671047749426	bayes_pls_golite062009
protein disulfide oxidoreductase activity	0.44918717550973	bayes_pls_golite062009
transferase activity	0.245320538630117	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [214-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTQALELTED DIKEDGIVPL RYVKFQNVNS VTLFVQSNQG EEETTRISYF TFIGTPVQAT  60
   61 NMNDFKRVVG KKGESH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.30103
Match:	1wwyA
Description:	Solution structure of the DUF1000 domain of a thioredoxin-like protein 1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: