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View Structure Prediction Details

Protein: FRDA_MOUSE
Organism: Mus musculus
Length: 207 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRDA_MOUSE.

Description E-value Query
Range
Subject
Range
gi|74195305 - gi|74195305|dbj|BAE28375.1| unnamed protein product [Mus musculus]
322.0 [0..1] [207..1]
gi|109463707 - gi|109463707|ref|XP_001078791.1| PREDICTED: similar to Frataxin, mitochondrial precursor (Fxn) [Ratt...
321.0 [0..1] [207..1]
FXN - frataxin
316.0 [0..1] [205..1]
gi|109111727 - gi|109111727|ref|XP_001093449.1| PREDICTED: similar to frataxin isoform 1 preproprotein [Macaca mula...
307.0 [0..1] [205..1]
gi|114624942 - gi|114624942|ref|XP_001137864.1| PREDICTED: frataxin [Pan troglodytes]
304.0 [0..1] [205..1]
FRDA_MACFA - Frataxin, mitochondrial OS=Macaca fascicularis GN=FXN PE=2 SV=1
303.0 [0..1] [205..1]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWAFGGRAAV GLLPRTASRA SAWVGNPRWR EPIVTCGRRG LHVTVNAGAT RHAHLNLHYL  60
   61 QILNIKKQSV CVVHL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [76-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNLGTLDNPS SLDETAYERL AEETLDSLAE FFEDLADKPY TLEDYDVSFG DGVLTIKLGG  60
   61 DLGTYVINKQ TPNKQIWLSS PSSGPKRYDW TGKNWVYSHD GVSLHELLAR ELTKALNTKL 120
  121 DLSSLAYSGK GT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.221849
Match: 1ekgA
Description: C-terminal domain of frataxin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
iron chaperone activity 4.16905358201916 bayes_pls_golite062009
ferric iron binding 3.23865994858009 bayes_pls_golite062009
iron ion binding 2.78584553912929 bayes_pls_golite062009
2 iron, 2 sulfur cluster binding 2.25545886640675 bayes_pls_golite062009
transition metal ion binding 1.85229574432416 bayes_pls_golite062009
binding 1.75179885686234 bayes_pls_golite062009
metallochaperone activity 1.67572555512957 bayes_pls_golite062009
ferrous iron binding 1.61332056179381 bayes_pls_golite062009
protein binding 1.50639308293007 bayes_pls_golite062009
cation binding 1.42164579673909 bayes_pls_golite062009
metal ion binding 1.42164579673909 bayes_pls_golite062009
ion binding 1.4150396069236 bayes_pls_golite062009
oxidoreductase activity 1.07282105096776 bayes_pls_golite062009
metal cluster binding 0.602901470550009 bayes_pls_golite062009
iron-sulfur cluster binding 0.602901470550009 bayes_pls_golite062009
oxidoreductase activity, oxidizing metal ions, oxygen as acceptor 0.310374472796773 bayes_pls_golite062009
ferroxidase activity 0.310374472796773 bayes_pls_golite062009
catalytic activity 0.276917867171685 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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