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View Structure Prediction Details

Protein: C209A_MOUSE
Organism: Mus musculus
Length: 238 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C209A_MOUSE.

Description E-value Query
Range
Subject
Range
gi|16660119, gi|... - gi|16660119|gb|AAL27539.1|AF374470_1 DC-SIGN neck-less isoform [Mus musculus], gi|148690009|gb|EDL21...
188.0 [0..1] [238..1]
gi|109496327, gi... - gi|34870126|ref|XP_221778.2| PREDICTED: similar to CD209a antigen [Rattus norvegicus], gi|157786866|...
184.0 [0..1] [238..1]
gi|15281085 - gi|15281085|gb|AAK91852.1| sDC-SIGN1A type III isoform [Homo sapiens]
182.0 [0..1] [235..1]
CD209_HYLLA - CD209 antigen OS=Hylobates lar GN=CD209 PE=3 SV=1
175.0 [0..6] [235..186]
209L2_MACMU - CD209 antigen-like protein 2 OS=Macaca mulatta GN=CD209L2 PE=1 SV=1
175.0 [0..1] [235..1]
gi|27356928 - gi|27356928|gb|AAL89544.1| putative CD209 protein [Pan troglodytes]
175.0 [0..6] [235..163]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSKEMGKR QLRPLDEELL TSSHTRHSIK GFGFQTNSGF SSFTGCLVHS QVPLALQVLF  60
   61 LAVCSVLLVV ILVKVYKIPS SQEENNQMNV Y

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QELTQLKAGV DRLCRSCPWD WTHFQGSCYF FSVAQKSWND SATACHNVGA QLVVIKSDEE  60
   61 QNFLQQTSKK RGYTWMGLID MSKESTWYWV DGSPLTLSFM KYWSKGEPNN LGEEDCAEFR 120
  121 DDGWNDTKCT NKKFWICKKL STSCPSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.522879
Match: 1sl6A
Description: Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 1.36045055857751 bayes_pls_golite062009
transmembrane receptor activity 1.10703123577063 bayes_pls_golite062009
signal transducer activity 0.715762096994006 bayes_pls_golite062009
molecular transducer activity 0.715762096994006 bayes_pls_golite062009
binding 0.656008673432897 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle