YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|58372411, gi\|...
Organism:	Plasmodium falciparum
Length:	453 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|58372411, gi|....

Description	E-value	Query Range	Subject Range
gi\|3095038 - gi\|3095038\|gb\|AAC15794.1\| plasmepsin [Plasmodium malariae]	392.0	[0..1]	[451..1]
PLM2_PLAFA - Plasmepsin-2 OS=Plasmodium falciparum PE=1 SV=1	387.0	[0..1]	[453..1]
gi\|46488407, gi\|... - gi\|46488411\|gb\|AAS99527.1\| aspartic protease PM4 [Plasmodium vivax], gi\|46488409\|gb\|AAS99526.1\| aspa...	374.0	[0..1]	[451..1]
gi\|3095036 - gi\|3095036\|gb\|AAC15793.1\| plasmepsin [Plasmodium ovale]	370.0	[0..1]	[451..1]
gi\|23497139, gi\|... - gi\|23509296\|ref\|NP_701963.1\| plasmepsin, putative [Plasmodium falciparum 3D7], gi\|23497139\|gb\|AAN366...	365.0	[0..1]	[451..1]
gi\|114637864 - gi\|114637864\|ref\|XP_001144824.1\| PREDICTED: pepsinogen 5, group I (pepsinogen A) isoform 2 [Pan trog...	365.0	[0..54]	[448..50]

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Predicted Domain #1

Region A:
Residues: [1-453]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDITVREHDF KHGFIKSNST FDGLNIDNSK NKKKIQKGFQ ILYVLLFCSV MCGLFYYVYE  60
   61 NVWLQRDNEM NEILKNSEHL TIGFKVENAH DRILKTIKTH KLKNYIKESV NFLNSGLTKT 120
  121 NYLGSSNDNI ELVDFQNIMF YGDAEVGDNQ QPFTFILDTG SANLWVPSVK CTTAGCLTKH 180
  181 LYDSSKSRTY EKDGTKVEMN YVSGTVSGFF SKDLVTVGNL SLPYKFIEVI DTNGFEPTYT 240
  241 ASTFDGILGL GWKDLSIGSV DPIVVELKNQ NKIENALFTF YLPVHDKHTG FLTIGGIEER 300
  301 FYEGPLTYEK LNHDLYWQIT LDAHVGNIML EKANCIVDSG TSAITVPTDF LNKMLQNLDV 360
  361 IKVPFLPFYV TLCNNSKLPT FEFTSENGKY TLEPEYYLQH IEDVGPGLCM LNIIGLDFPV 420
  421 PTFILGDPFM RKYFTVFDYD NQSVGIALAK KNL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	108.0
Match:	2bjuA
Description:	Plasmepsin II complexed with a highly active achiral inhibitor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aspartic-type endopeptidase activity	7.9145950161796	bayes_pls_golite062009
aspartic-type peptidase activity	7.9145950161796	bayes_pls_golite062009
peptidase activity	5.78181196721293	bayes_pls_golite062009
endopeptidase activity	5.4888481808613	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	5.39972232367526	bayes_pls_golite062009
hydrolase activity	4.34796304893506	bayes_pls_golite062009
catalytic activity	1.54514410489082	bayes_pls_golite062009
binding	1.10054369202721	bayes_pls_golite062009
receptor binding	0.561225023505917	bayes_pls_golite062009
protein binding	0.193907750061394	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: