YRC Public Data Repository - Protein Structure Prediction

Protein:	EHS1_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	486 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EHS1_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|11280533 - gi\|11280533\|pir\|\|JC7212 stretch-activated Ca2+-permeable channel protein homolog, Yam8 - fission yea...	720.0	[0..1]	[486..1]
gi\|28949941 - gi\|28949941\|emb\|CAD70927.1\| related to MID1 protein [Neurospora crassa]	562.0	[0..33]	[481..160]
gi\|28922554, gi\|... - gi\|32413018\|ref\|XP_326989.1\| hypothetical protein [Neurospora crassa], gi\|28922554\|gb\|EAA31782.1\| hy... gi\|85100713 - gi\|85100713\|ref\|XP_961018.1\| hypothetical protein [Neurospora crassa OR74A]	544.0	[0..33]	[470..160]
gi\|42554592, gi\|... - gi\|46126081\|ref\|XP_387594.1\| hypothetical protein FG07418.1 [Gibberella zeae PH-1], gi\|42554592\|gb\|E...	534.0	[0..42]	[482..122]
gi\|45190410, gi\|... - gi\|45190410\|ref\|NP_984664.1\| AEL197Cp [Ashbya gossypii ATCC 10895], gi\|44983306\|gb\|AAS52488.1\| AEL19... gi\|44983306 - gi\|44983306\|gb\|AAS52488.1\| AEL197Cp [Ashbya gossypii ATCC 10895]	520.0	[0..28]	[462..44]
gi\|68490426, gi\|... - gi\|68490426\|ref\|XP_710963.1\| hypothetical protein CaO19.10724 [Candida albicans SC5314], gi\|46432228... orf19.10724 - MID1 CGDID:CAL0003216 Assembly 19, Contig19-20171 (11393, 9714) CDS, reverse complemented, translate...	513.0	[0..19]	[483..99]
gi\|39943980, gi\|... - gi\|39943980\|ref\|XP_361527.1\| hypothetical protein MG04001.4 [Magnaporthe grisea 70-15], gb\|EAA50242....	511.0	[0..37]	[461..397]
gi\|27447377, gi\|... - gi\|27447377\|gb\|AAM47512.1\| calcium channel MID1 [Aspergillus nidulans], gi\|27447361\|gb\|AAM47511.1\| c... gi\|49130549, gi\|... - gi\|67903710\|ref\|XP_682111.1\| hypothetical protein AN8842.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	481.0	[0..22]	[484..106]
gi\|151944256 - gi\|151944256\|gb\|EDN62535.1\| conserved protein [Saccharomyces cerevisiae YJM789] MID1_YEAST - Stretch-activated cation channel MID1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MI... gi\|207341958 - gi\|207341958\|gb\|EDZ69872.1\| YNL291Cp-like protein [Saccharomyces cerevisiae AWRI1631] MID1 - N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stre... gi\|190409259 - gi\|190409259\|gb\|EDV12524.1\| N-glycosylated integral plasma membrane protein [Saccharomyces cerevisia...	444.0	[0..69]	[459..95]

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Predicted Domain #1

Region A:
Residues: [1-184]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFFFSTHLIL KILFFWSITR NIFGATYTSL LLNNTINGNI NDQSTAYYNL TWEGNTAYNV  60
   61 SLTLSTCTAF DGANDLMLYI SNNTFDEALP LDNFTITASE NGLATIFVTG YSPLYIAVSS 120
  121 AFSQFAPNFF VESGESTLEG NNVINYELAA GIDTPFSQYN ATKFLFAQDT DFQAALLITG 180
  181 NLTT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [185-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NETSIIPSYE IYVNPSNSTY DNTFNKFSSS FCAFQNNPST VNTNNADRSM TLRGLGPFAK  60
   61 EQFYLKGLDP NVTYTAYLVE PNIG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [269-486]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPGGTVYPGV TFTTKTSPAC QLIYDLQFCS EVAYAVPGNS SLFSASALAE WYDQQAYGYY  60
   61 QNFTYTLDLI PCNATSWSAY SLLKNCSDCA NSYKNWLCAS VIPRCADIND NSSYLIYKNY 120
  121 DSRYPLIDEV IQPGPYKEVL PCSYLCYSLA SSCPLDLGFA CPKAGYGLEF SYGEVSNVTG 180
  181 LITCNAPGVE FYESGSALLN ISWRTFFISL IFWILFVE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.57
Match:	1ijxA
Description:	Secreted Frizzled-related protein 3 (SFRP-3;fzb)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transmembrane receptor activity	1.96928126941717	bayes_pls_golite062009
receptor activity	1.93198638186764	bayes_pls_golite062009
binding	1.7353571770087	bayes_pls_golite062009
signal transducer activity	1.71958201584504	bayes_pls_golite062009
molecular transducer activity	1.71958201584504	bayes_pls_golite062009
protein binding	1.03919942773652	bayes_pls_golite062009
Wnt receptor activity	0.129505171265921	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: