YRC Public Data Repository - Protein Structure Prediction

Protein:	METE_YERPN
Organism:	Yersinia pestis Nepal516
Length:	758 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for METE_YERPN.

Description	E-value	Query Range	Subject Range
gi\|89104874 - gi\|89104874\|ref\|ZP_01177405.1\| COG0620: Methionine synthase II (cobalamin-independent) [Yersinia pes... gi\|167426239, gi... - gi\|167426239\|ref\|ZP_02317992.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer... gi\|22124357, gi\|... - gi\|22124357\|ref\|NP_667780.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [... gi\|77633875, gi\|... - gi\|77633875\|ref\|ZP_00795989.1\| COG0620: Methionine synthase II (cobalamin-independent) [Yersinia pes... gi\|167401849, gi... - gi\|167401849\|ref\|ZP_02307337.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer... gi\|166213623, gi... - gi\|166213623\|ref\|ZP_02239658.1\| 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransfer...	0.0	[1..758]	[6..763]
gi\|77630686, gi\|... - gi\|77630686\|ref\|ZP_00793272.1\| COG0620: Methionine synthase II (cobalamin-independent) [Yersinia pse...	0.0	[1..758]	[6..763]
gi\|77973685 - gi\|77973685\|ref\|ZP_00829231.1\| COG0620: Methionine synthase II (cobalamin-independent) [Yersinia fre...	0.0	[1..758]	[1..758]
METE_YERPS - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Yersinia pseudotuberculosis... METE_YERPS - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Yersinia pseudotuberculosis...	0.0	[1..758]	[1..758]
METE_PHOLL - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Photorhabdus luminescens su... METE_PHOLL - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Photorhabdus luminescens su...	0.0	[1..755]	[1..755]
METE_ECOK1 - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Escherichia coli O1:K1 / AP...	0.0	[1..754]	[1..751]
METE_ECO45 - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Escherichia coli O45:K1 (st... gi\|237702839, gi... - gi\|237702839\|ref\|ZP_04533320.1\| 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase... METE_ECOUT - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Escherichia coli (strain UT...	0.0	[1..754]	[1..751]
gi\|75256247, gi\|... - gi\|75256247\|ref\|ZP_00727925.1\| COG0620: Methionine synthase II (cobalamin-independent) [Escherichia ... gi\|193067979, gi... - gi\|75238279\|ref\|ZP_00722278.1\| COG0620: Methionine synthase II (cobalamin-independent) [Escherichia ... gi\|75209544, gi\|... - gi\|75209544\|ref\|ZP_00709765.1\| COG0620: Methionine synthase II (cobalamin-independent) [Escherichia ...	0.0	[1..754]	[1..751]
METE_SHISS - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Shigella sonnei (strain Ss0... METE_ECOSE - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Escherichia coli (strain SE...	0.0	[1..754]	[1..751]
METE_ECO24 - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Escherichia coli O139:H28 (...	0.0	[1..754]	[1..751]

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Predicted Domain #1

Region A:
Residues: [1-758]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTILNHTLGF PRVGLKRELK KAQESYWAGN STQEELLNVG RELRARHWQQ QQQAGVDLVP  60
   61 VGDFAWYDHV LTTSLLLGNV PERHQNADGS IDIDTLFRIG RGRAPTGKPA AAAEMTKWFN 120
  121 TNYHYMVPEF QQGQQFKLGW TQLLDEVDEA LALGHKIKPV LLGPITYLWL GKVKGEQFDR 180
  181 LSLLNDILPV YQQVLAELAK RGIEWVQIDE PALVLELPQE WLDAYQPAYQ ALQGQVKLLL 240
  241 TTYFDSIGHN IDTIRALPVQ GLHVDVVTGH DDLAVLNKNL PKEWLLSLGV INGRNVWRAD 300
  301 LSSWFERLQP LVNSRPLWLG SSCSLLHSPI DLNEETRLDA EVKSWFAFAL QKCAELALLT 360
  361 QALNAPNDAK LAELAAYSAP IRARRSSSRV HNAQVEQRLA AITSQDIERQ LPYEARAETQ 420
  421 RKRFNLPAWP TTTIGSFPQT TEIRGLRLDF KQGRLDGKNY RTGISEHIKH AIAEQERLGL 480
  481 DVLVHGEAER NDMVEYFGEH LDGFVFTQNG WVQSYGSRCV KPPVIIGDIS RPEAITVEWA 540
  541 KYAQSLTEKP VKGMLTGPVT ILCWSFPRED VSRETIAKQI ALALRDEVED LEKAGIGIIQ 600
  601 IDEPALREGL PLRRADWQAY LQWAVDAFKL NAAVAQNDTQ IHTHMCYCEF NDIMDSIAAL 660
  661 DADVITIETS RSDMELLESF EDFAYPNEIG PGVYDIHSPN VPSVEWIEAL LRKAAQRIPA 720
  721 ERLWVNPDCG LKTRGWPETR QALANMVLAA QRLREEQV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1u1hA
Description:	A. thaliana cobalamine independent methionine synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	6.40786073037099	bayes_pls_golite062009
5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity	6.40786073037099	bayes_pls_golite062009
uroporphyrinogen decarboxylase activity	3.13638443707338	bayes_pls_golite062009
S-methyltransferase activity	3.0142199413027	bayes_pls_golite062009
catalytic activity	2.37862248560593	bayes_pls_golite062009
binding	1.590130518929	bayes_pls_golite062009
carbon-carbon lyase activity	1.54242506764415	bayes_pls_golite062009
carboxy-lyase activity	1.52150758949987	bayes_pls_golite062009
lyase activity	0.825209465219608	bayes_pls_golite062009
protein binding	0.21865699924356	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: