YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|165915408, gi...
Organism:	Yersinia pestis biovar Orientalis str. IP275
Length:	875 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|165915408, gi....

Description	E-value	Query Range	Subject Range
gi\|75241640, gi\|... - gi\|75241640\|ref\|ZP_00725477.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli F11], gi\|191171366\|...	0.0	[1..875]	[1..875]
gi\|227888232, gi... - gi\|227888232\|ref\|ZP_04006037.1\| alanyl-tRNA synthetase [Escherichia coli 83972], gi\|227834501\|gb\|EEJ... SYA_ECOHS - Alanine--tRNA ligase OS=Escherichia coli O9:H4 (strain HS) GN=alaS PE=3 SV=1 gi\|218428383, gi... - gi\|218690819\|ref\|YP_002399031.1\| alanyl-tRNA synthetase [Escherichia coli ED1a], gi\|218428383\|emb\|CA...	0.0	[1..875]	[1..875]
gi\|75512393, gi\|... - gi\|75512393\|ref\|ZP_00734945.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli 53638], gi\|18849203... gi\|238901834, gi... - gi\|238901834\|ref\|YP_002927630.1\| alanyl-tRNA synthetase [Escherichia coli BW2952], gi\|238859951\|gb\|A... SYA_ECODH - Alanine--tRNA ligase OS=Escherichia coli (strain K12 / DH10B) GN=alaS PE=3 SV=1 SYA_ECOLI - Alanyl-tRNA synthetase (EC 6.1.1.7) (Alanine--tRNA ligase) (AlaRS) - Escherichia coli gi\|1800083, gi\|8... - gi\|89109484\|ref\|AP_003264.1\| alanyl-tRNA synthetase [Escherichia coli str. K-12 substr. W3110], gi\|1... EG10034 - alanyl-tRNA synthetase / Alanine--tRNA ligase, autorepressor gi\|194422121, gi... - gi\|83585644\|ref\|ZP_00924287.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli 101-1], gi\|19443900... gi\|226839360, gi... - gi\|254037736\|ref\|ZP_04871794.1\| alanyl t-RNA synthetase [Escherichia sp. 1_1_43], gi\|226839360\|gb\|EE... EG10034 - alanyl-tRNA synthetase / Alanine--tRNA ligase, autorepressor	0.0	[1..875]	[1..875]
SYA_ECOL5 - Alanine--tRNA ligase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=alaS PE=3 SV=1	0.0	[1..875]	[1..875]
SYA_SHISS - Alanine--tRNA ligase OS=Shigella sonnei (strain Ss046) GN=alaS PE=3 SV=1 gi\|209920136, gi... - gi\|209920136\|ref\|YP_002294220.1\| alanyl-tRNA synthetase [Escherichia coli SE11], gi\|209913395\|dbj\|BA... gi\|75256897, gi\|... - gi\|75256897\|ref\|ZP_00728473.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli E22], gi\|193065058\|... gi\|193069650, gi... - gi\|75235710\|ref\|ZP_00719884.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli E110019], gi\|193069... gi\|218555239, gi... - gi\|218555239\|ref\|YP_002388152.1\| alanyl-tRNA synthetase [Escherichia coli IAI1], gi\|218362007\|emb\|CA... gi\|218353020, gi... - gi\|218696288\|ref\|YP_002403955.1\| alanyl-tRNA synthetase [Escherichia coli 55989], gi\|218353020\|emb\|C... gi\|75229772, gi\|... - gi\|75229772\|ref\|ZP_00716302.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli B7A], gi\|191167095\|... gi\|194427866, gi... - gi\|75210896\|ref\|ZP_00711020.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli B171], gi\|194427866... SYA_ECO24 - Alanine--tRNA ligase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=alaS PE=3 SV=1	0.0	[1..875]	[1..875]
gi\|218366454, gi... - gi\|218559685\|ref\|YP_002392598.1\| alanyl-tRNA synthetase [Escherichia coli S88], gi\|218366454\|emb\|CAR... SYA_ECOK1 - Alanine--tRNA ligase OS=Escherichia coli O1:K1 / APEC GN=alaS PE=3 SV=1 gi\|237706683, gi... - gi\|237706683\|ref\|ZP_04537164.1\| alanyl-tRNA synthetase [Escherichia sp. 3_2_53FAA], gi\|226899723\|gb\|... SYA_ECOUT - Alanine--tRNA ligase OS=Escherichia coli (strain UTI89 / UPEC) GN=alaS PE=3 SV=1	0.0	[1..875]	[1..875]
SYA_SHIDS - Alanine--tRNA ligase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=alaS PE=3 SV=1	0.0	[1..875]	[1..875]
SYA_SHIBS - Alanine--tRNA ligase OS=Shigella boydii serotype 4 (strain Sb227) GN=alaS PE=3 SV=1	0.0	[1..875]	[1..875]
gi\|56480163, gi\|... - gi\|56480163\|ref\|NP_708505.2\| alanyl-tRNA synthetase [Shigella flexneri 2a str. 301], gi\|56383714\|gb\|... SYA_SHIF8 - Alanine--tRNA ligase OS=Shigella flexneri serotype 5b (strain 8401) GN=alaS PE=3 SV=1 SYA_SHIFL - Alanine--tRNA ligase OS=Shigella flexneri GN=alaS PE=3 SV=1 gi\|30064057, gi\|... - gi\|30064057\|ref\|NP_838228.1\| alanyl-tRNA synthetase [Shigella flexneri 2a str. 2457T], gi\|30042313\|g...	0.0	[1..875]	[1..875]
gi\|15832808, gi\|... - gi\|15832808\|ref\|NP_311581.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. Sakai], gi\|133630... gi\|168774775, gi... - gi\|187769613\|gb\|EDU33457.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4196], gi\|168774... gi\|189003197, gi... - gi\|189003197\|gb\|EDU72183.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4076], gi\|168778... gi\|189377449, gi... - gi\|189377449\|gb\|EDU95865.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC508], gi\|1688002... gi\|25293071 - pir\|\|B91073 alanyl-tRNA synthetase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 050... gi\|195938445 - gi\|195938445\|ref\|ZP_03083827.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4024] gi\|208805868, gi... - gi\|208805868\|ref\|ZP_03248205.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4206], gi\|20... gi\|208735038, gi... - gi\|208813761\|ref\|ZP_03255090.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|208738409, gi... - gi\|208818286\|ref\|ZP_03258606.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4042], gi\|20... gi\|209160191, gi... - gi\|209398791\|ref\|YP_002272160.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4115], gi\|2... gi\|168749982, gi... - gi\|188015823\|gb\|EDU53945.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4113], gi\|168749... gi\|189357241, gi... - gi\|189357241\|gb\|EDU75660.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4401], gi\|168755... gi\|189366853, gi... - gi\|189366853\|gb\|EDU85269.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4501], gi\|168762... SYA_ECO57 - Alanine--tRNA ligase OS=Escherichia coli O157:H7 GN=alaS PE=3 SV=2 gi\|189362083, gi... - gi\|189362083\|gb\|EDU80502.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4486], gi\|168768... gi\|83569947, gi\|... - gi\|83569947\|ref\|ZP_00921395.1\| COG0013: Alanyl-tRNA synthetase [Shigella dysenteriae 1012], gi\|19443... gi\|217327497, gi... - gi\|217327497\|ref\|ZP_03443580.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14588], gi\|2... gi\|254594038, gi... - gi\|254794638\|ref\|YP_003079475.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14359], gi\|...	0.0	[1..875]	[1..875]

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Predicted Domain #1

Region A:
Residues: [1-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKSTAEIRQ AFLDFFHSKG HQVVSSSTLV PNNDPTLLFT NAGMNQFKDV FLGLDKRAYS  60
   61 RATTSQRCVR AGGKHNDLEN VGYTARHHTF FEMLGNFSFG DYFKHDAINF AWELLTSEQW 120
  121 FNLPKEKLWV TVYETDDEAY NIWANEVGVP HERIIRIGDN KGGAFASDNF WQMGDTGPCG 180
  181 PCSEIFFDHG DHIWGGPPGS AEEDGDRYIE IWNIVFMQFN RQSDGTMLPL PKPSVDTGMG 240
  241 LERIAAVLQH VNSNYEIDLF RDLIAAVADV TGATDLSSKS LRVIADHIRS CAFLISDGVI 300
  301 PSNENRGYVL RRIIRRAIRH GNMLGAKETF FYKLVAPLIA VMGPAAAELK QQQAMVEQVL 360
  361 KTEEEQFART LERGLALLDD ELSKLTGDTL DGETAFRLYD TYGFPVDLTA DVCRERNLKV 420
  421 DEAGFEQAME AQRRRARESS GFGADYNSLI RVDSASQFS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1riqA
Description:	The crystal structure of the catalytic fragment of the alanyl-tRNA synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.89468709683036	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.89468709683036	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.88410036819636	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
alanine-tRNA ligase activity	6.00693881794242	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	2.99105702052936	bayes_pls_golite062009
serine-tRNA ligase activity	2.46505535069103	bayes_pls_golite062009
glycine-tRNA ligase activity	2.29229136935761	bayes_pls_golite062009
threonine-tRNA ligase activity	2.18642354927	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
lysine-tRNA ligase activity	1.72324031407565	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
transcription regulator activity	1.47976803533584	bayes_pls_golite062009
nucleic acid binding	1.30216701059664	bayes_pls_golite062009
DNA binding	1.1862497958336	bayes_pls_golite062009
binding	1.11470390774037	bayes_pls_golite062009
asparagine-tRNA ligase activity	0.921492123574877	bayes_pls_golite062009
transcription repressor activity	0.80781620905336	bayes_pls_golite062009
transcription factor activity	0.566858624145031	bayes_pls_golite062009
RNA binding	0.0221706730298825	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.00572514744734753	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [460-526]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYDHVQQHAT VTALFRNGEA VDEIHAGEEA VVVLNRTPFY GESGGQVGDK GELKNATATF  60
   61 SVTDTQK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.69897
Match:	2e1bA
Description:	No description for 2e1bA was found.

Predicted Domain #3

Region A:
Residues: [527-796]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGQAIGHVGI LTTGTLRVNH SVEALVDVVR RNRIRLNHSA THLLHAALRN VLGEHVAQKG  60
   61 SLVNDKYLRF DFSHFEAMKP EQIRLVEDLV NEQIRRNMPV QTEVMELDAA KEKGAMALFG 120
  121 EKYDDQVRVL TMGDFSTELC GGTHASRTGD IGLFRILTES GTAAGIRRIE AVTGEGAIAL 180
  181 LHQQSDLLQD VAHLVKGDIH NLADKVRAVL DRSKMLEREL QQLKDQQAAQ ESASLSSSAK 240
  241 LINGVKLLVS QLDNVEPKML RTMVDDLKNQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.0
Match:	1qf6A
Description:	Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [797-875]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGSAIIVLAT TADDKVSLIV GVTKDLTGKV KAGELIADIA QQVGGKGGGR PDMAQAGGTD  60
   61 VQALPAALAS VEAWVASRM

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	20.920819
Match:	PF02272.10
Description:	No description for PF02272.10 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: