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View Structure Prediction Details

Protein: FBpp0297355, Gyc...
Organism: Drosophila melanogaster
Length: 1097 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0297355, Gyc....

Description E-value Query
Range
Subject
Range
Gyc88E-PC - The gene Guanylyl cyclase at 88E is referred to in FlyBase by the symbol Dmel\Gyc88E (CG4154, FBgn00...
717.0 [0..1] [946..1]

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Predicted Domain #1
Region A:
Residues: [1-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYGLLLENLS EYIKSVYGEE KWEDIRRQAG IDSPSFSVHQ VYPENLLQKL AKKAQQVLGV  60
   61 SERDFMDQMG VYFVGFVGQY GYDRVLSVLG RHMRDFLNGL DNLHEYLKFS YPRMRAPSFI 120
  121 CENETKQGLT LHYRSKRRGF VYYTMGQIRE VARYFYHKEM HIELVREEIL FDTVHVTFQL 180
  181 TFDNRAFT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.154902
Match: 2o09A
Description: No description for 2o09A was found.

Predicted Domain #2
Region A:
Residues: [189-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LASLAMTREE KHLPISAHVL FEIFPFCMVF GADMVVRSIG NSLMVILPEL LGKKITAWFD  60
   61 LVRPLIAFKF QTILNRTNNI FELVTVDPVT ERFDVQNEDL LQHEDGSEPE KSLRLKGQMV 120
  121 YMENWRMIMF LGTPVMPDLT SLITTGLYIN DLSMHDFSRD LMLAGTQQSV ELKLALDQEQ 180
  181 QKSKKLEESM RLLDEEMRRT DELLYQMI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [397-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKQVADRLRR GENPIDTCEM FDSVSILFSD IVTFTEICSR ITPMEVVSML NAMYSIFDKL  60
   61 TERNSVYKVE TIGDAYMVVA GAPDKDANHA ERVCDMALDM VDAITDLKDP STGQHLRIRV 120
  121 GVHSGAVVAG IVGLKMPRYC LFGDTVNTAS RMESTSIAMK VHISESTKVL IGPNYKIIER 180
  181 GEIDVKGKGT MGTYWLEERE NRLPLQLTAA LQVHPLSPVP PTPTPKTKAI MPPVSKPLTP 240
  241 MMPVSVSLAA S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.30103
Match: 1azsA
Description: Adenylyl cyclase VC1, domain C1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
guanylate cyclase activity 10.3848465380008 bayes_pls_golite062009
cyclase activity 9.56622318762576 bayes_pls_golite062009
phosphorus-oxygen lyase activity 9.13872073463964 bayes_pls_golite062009
adenylate cyclase activity 2.79108987859397 bayes_pls_golite062009
signal transducer activity 1.32485567900717 bayes_pls_golite062009
molecular transducer activity 1.32485567900717 bayes_pls_golite062009
transcription regulator activity 1.12394944257466 bayes_pls_golite062009
protein binding 0.835166604872659 bayes_pls_golite062009
binding 0.407021407526425 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [648-740]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTSNVPAVD VMASSSSISG LALTAAAAAH MSLHHQAVVA EALTGASVEV ALPSVASGAT  60
   61 GAAAGGGAPS DDRNSRIYSP VTFKDVARRS VAN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [741-805]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPVRSCAQPD QERRRESRSN STGHVFMRTP SEIFGSLILD TEEFLEDLQI SRSSLANNNN  60
   61 NQSPC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [806-916]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFSPTPPFRI GSAPPKPRPS NPDKFTPEEL AAMDQLTPPS TAPARETASC SSASLDRDKA  60
   61 TKLKKITFSN SSSLDATTPT ALAAVVCPMR TKSPPMAVAP VMHMVQASTS K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [917-1097]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDGQRPGSKD SVSSISLHSP PPHRSNSAPA RPHSMSKAAR KAFLAAKQTK AMEKLDKMIE  60
   61 EVQEVESQSV AKAANMRLAL YGHDGGGDLA AGGCPLFLPP PPQQQQQQQQ SLMPSSISDS 120
  121 GLCSHGHSHA PSCHHMDPKM TNSQSFQHSP RGGITHQCCS GFGHGNGRHS HRMHSNACRI 180
  181 L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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