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View Structure Prediction Details

Protein: sdt-PH
Organism: Drosophila melanogaster
Length: 934 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sdt-PH.

Description E-value Query
Range
Subject
Range
sdt-PF - The gene stardust is referred to in FlyBase by the symbol Dmel\sdt (CG32717, FBgn0243505). It is a p...
599.0 [0..76] [934..1]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRILKQWNRR RSGSSIVVLD GDDLKPCLPD DYISGQHHLN HQQQLQLQQQ LQQQHPLQQQ  60
   61 HYRTHSGDIR EIDQEMLTML SVNQDNGPHR EMAVDCPDTF IARNKTPP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [109-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYPPPRPPQL NGNAKPVPPP RDHLRVEKDG RLVNCSPAPQ LPDRRAPGNA SSGSSGATTH  60
   61 PLQHQQIAQI VEPTLEQLDS IKKYQEQLRR RREEEERIAQ QNEFLRNSLR GSRKLKALQD 120
  121 TATPGKAVAQ QQQQATLATQ VVGVENEAYL PDEDQPQAEQ IDGYGELIAA LTRLQNQLSK 180
  181 SGLSTLAGRV SAAHSVLASA SVAHVLAART AVLQRRRSRV SGPL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [333-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHSSLGLQKD IVELLTQSNT AAAIELGNLL TSHEMEGLLL AHDRIANHTD G

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.52
Match: 1zl8B
Description: NMR structure of L27 heterodimer from C. elegans Lin-7 and H. sapiens Lin-2 scaffold proteins
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [384-470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPSPTPTPTP AIGAATGSTL SSPVAGPKRN LGMVVPPPVV PPPLAQRGAM PLPRGESPPP  60
   61 VPMPPLATMP MSMPVNLPMS ACFGTLN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [471-571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQNDNIRIIQ IEKSTEPLGA TVRNEGEAVV IGRIVRGGAA EKSGLLHEGD EILEVNGQEL  60
   61 RGKTVNEVCA LLGAMQGTLT FLIVPAGSPP SVGVMGGTTG S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 1va8A
Description: Solution structure of the PDZ domain of Pals1 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.2595117613307 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 3.03529700765506 bayes_pls_golite062009
substrate-specific transporter activity 2.83180079733297 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.39826531242265 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
nucleotide kinase activity 1.79696347300128 bayes_pls_golite062009
guanylate kinase activity 1.70730560221787 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.69528181005421 bayes_pls_golite062009
signal transducer activity 1.51162321843898 bayes_pls_golite062009
molecular transducer activity 1.51162321843898 bayes_pls_golite062009
cytoskeletal protein binding 1.00130123171287 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
transcription regulator activity 0.387065538161985 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [572-934]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLAGLGGAHR DTAVLHVRAH FDYDPEDDLY IPCRELGISF QKGDVLHVIS REDPNWWQAY  60
   61 REGEEDQTLA GLIPSQSFQH QRETMKLAIA EEAGLARSRG KDGSGSKGAT LLCARKGRKK 120
  121 KKKASSEAGY PLYATTAPDE TDPEEILTYE EVALYYPRAT HKRPIVLIGP PNIGRHELRQ 180
  181 RLMADSERFS AAVPHTSRAR REGEVPGVDY HFITRQAFEA DILARRFVEH GEYEKAYYGT 240
  241 SLEAIRTVVA SGKICVLNLH PQSLKLLRAS DLKPYVVLVA PPSLDKLRQK KLRNGEPFKE 300
  301 EELKDIIATA RDMEARWGHL FDMIIINNDT ERAYHQLLAE INSLEREPQW VPAQWVHNNR 360
  361 DES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.0
Match: 1kjwA
Description: Psd-95; Guanylate kinase-like domain of Psd-95
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle