YRC Public Data Repository - Protein Structure Prediction

Protein:	CAH3_MOUSE
Organism:	Mus musculus
Length:	260 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAH3_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|35505160, gi\|... - gi\|40363537\|ref\|NP_954685.1\| carbonic anhydrase II [Danio rerio], gi\|35505160\|gb\|AAH57412.1\| Carboni...	389.0	[0..1]	[260..1]
CAH2_TRIHK - Carbonic anhydrase 2 OS=Tribolodon hakonensis GN=ca2 PE=2 SV=3	386.0	[0..1]	[260..1]
gi\|60831506 - gi\|60831506\|gb\|AAX36973.1\| carbonic anhydrase II [synthetic construct]	383.0	[0..1]	[260..1]
gi\|11513608 - gi\|11513608\|pdb\|1G6V\|A Chain A, Complex Of The Camelid Heavy-Chain Antibody Fragment Cab- Ca05 With ... gi\|123995657, gi... - gi\|123995657\|gb\|ABM85430.1\| carbonic anhydrase II [synthetic construct], gi\|123980834\|gb\|ABM82246.1\|... CA2 - carbonic anhydrase II	383.0	[0..1]	[260..1]
gi\|109086851 - gi\|109086851\|ref\|XP_001096360.1\| PREDICTED: carbonic anhydrase II [Macaca mulatta]	382.0	[0..1]	[260..1]
gi\|22252956 - gi\|22252956\|gb\|AAM94169.1\| erythrocyte carbonic anhydrase [Lepisosteus osseus]	381.0	[0..1]	[260..1]
gi\|73762632 - gi\|73762632\|gb\|AAZ83743.1\| carbonic anhydrase [Cyprinus carpio]	381.0	[0..1]	[260..1]

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Predicted Domain #1

Region A:
Residues: [1-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKEWGYASH NGPDHWHELY PIAKGDNQSP IELHTKDIKH DPSLQPWSAS YDPGSAKTIL  60
   61 NNGKTCRVVF DDTYDRSMLR GGPLSGPYRL RQFHLHWGSS DDHGSEHTVD GVKYAAELHL 120
  121 VHWNPKYNTF GEALKQPDGI AVVGIFLKIG REKGEFQILL DALDKIKTKG KEAPFTHFDP 180
  181 SCLFPACRDY WTYHGSFTTP PCEECIVWLL LKEPMTVSSD QMAKLRSLFS SAENEPPVPL 240
  241 VGNWRPPQPV KGRVVRASFK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	104.0
Match:	1fljA
Description:	Carbonic anhydrase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbonate dehydratase activity	2.35405414226159	bayes_pls_golite062009
binding	1.59667704693142	bayes_pls_golite062009
protein binding	1.30419076438266	bayes_pls_golite062009
catalytic activity	0.97285738666961	bayes_pls_golite062009
zinc ion binding	0.744428270762821	bayes_pls_golite062009
transition metal ion binding	0.36067052386032	bayes_pls_golite062009
carbon-oxygen lyase activity	0.0641135521348118	bayes_pls_golite062009
hydro-lyase activity	0.0479238316186823	bayes_pls_golite062009
lyase activity	0.0337150119314038	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: