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View Structure Prediction Details

Protein: MPRD_MOUSE
Organism: Mus musculus
Length: 278 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPRD_MOUSE.

Description E-value Query
Range
Subject
Range
MPRD_RAT - Cation-dependent mannose-6-phosphate receptor OS=Rattus norvegicus GN=M6pr PE=1 SV=1
398.0 [0..1] [278..1]
gi|74225999 - gi|74225999|dbj|BAE28758.1| unnamed protein product [Mus musculus]
398.0 [0..1] [278..1]
MPRD_BOVIN - Cation-dependent mannose-6-phosphate receptor OS=Bos taurus GN=M6PR PE=1 SV=1
394.0 [0..1] [278..2]
gi|90085425 - gi|90085425|dbj|BAE91453.1| unnamed protein product [Macaca fascicularis]
CCDS8598.1_1 - null
gi|109095542, gi... - gi|109095544|ref|XP_001113952.1| PREDICTED: cation-dependent mannose-6-phosphate receptor isoform 6 ...
394.0 [0..1] [278..1]
M6PR - mannose-6-phosphate receptor (cation dependent)
gi|114643402, gi... - gi|114643402|ref|XP_001137569.1| PREDICTED: cation-dependent mannose-6-phosphate receptor isoform 4 ...
392.0 [0..1] [278..1]
gi|57106524 - gi|57106524|ref|XP_534894.1| PREDICTED: similar to Cation-dependent mannose-6-phosphate receptor pre...
385.0 [0..1] [278..119]

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Predicted Domain #1
Region A:
Residues: [1-186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPFSGCWRT ELLLLLLLAV AVRESWQIEE KSCDLVGEKD KESKNEVALL ERLRPLFNKS  60
   61 FESTVGQGSD TYSYIFRVCR EASNHSSGAG LVQINKSNDK ETVVGRINET HIFNGSNWIM 120
  121 LIYKGGDEYD NHCGKEQRRA VVMISCNRHT LAANFNPVSE ERGKVQDCFY LFEMDSSLAC 180
  181 SPEVSH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.0
Match: 1keoA
Description: Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.16567725130191 bayes_pls_golite062009
transmembrane receptor activity 1.7623085294263 bayes_pls_golite062009
binding 1.63474009393214 bayes_pls_golite062009
mannose binding 1.47777842440942 bayes_pls_golite062009
glycoprotein binding 1.21372567656775 bayes_pls_golite062009
protein binding 1.14178057175691 bayes_pls_golite062009
growth factor binding 1.13825996944044 bayes_pls_golite062009
signal transducer activity 1.07094403673351 bayes_pls_golite062009
molecular transducer activity 1.07094403673351 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.93864424825473 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.87739040385088 bayes_pls_golite062009
carbohydrate binding 0.787496317925942 bayes_pls_golite062009
protein tyrosine kinase activity 0.38688318553501 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [187-278]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSVGSILLVI FASLVAVYII GGFLYQRLVV GAKGMEQFPH LAFWQDLGNL VADGCDFVCR  60
   61 SKPRNVPAAY RGVGDDQLGE ESEERDDHLL PM

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 11.79588
Match: PF02157.6
Description: No description for PF02157.6 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle