YRC Public Data Repository - Protein Structure Prediction

Protein:	POMT2
Organism:	Homo sapiens
Length:	750 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POMT2.

Description	E-value	Query Range	Subject Range
gi\|114654130 - gi\|114654130\|ref\|XP_510091.2\| PREDICTED: putative protein O-mannosyltransferase isoform 5 [Pan trogl...	0.0	[1..750]	[1..750]
gi\|6492005, gi\|2... - gi\|6492005\|gb\|AAF14118.1\|AF105020_1 putative protein O-mannosyltransferase [Homo sapiens], gi\|262794...	0.0	[1..750]	[1..750]
gi\|109084407 - gi\|109084407\|ref\|XP_001101522.1\| PREDICTED: putative protein O-mannosyltransferase [Macaca mulatta]	0.0	[1..750]	[1..750]
POMT2_MOUSE - Protein O-mannosyl-transferase 2 OS=Mus musculus GN=Pomt2 PE=1 SV=1	0.0	[1..750]	[71..820]
gi\|110278363, gi... - gi\|149025258\|gb\|EDL81625.1\| rCG20643 [Rattus norvegicus], gi\|114051267\|ref\|NP_001040579.1\| protein-O...	0.0	[1..750]	[71..820]
gi\|85118928 - gi\|85118928\|ref\|XP_965543.1\| hypothetical protein NCU01912 [Neurospora crassa OR74A] gi\|32417248, gi\|... - gi\|32417248\|ref\|XP_329102.1\| hypothetical protein [Neurospora crassa], gi\|28927353\|gb\|EAA36307.1\| hy...	0.0	[56..750]	[67..769]
gi\|14625800 - gi\|14625800\|gb\|AAK71510.1\| dolichyl-phosphate-mannose:protein mannosyltransferase [Emericella nidula... gi\|49095562, gi\|... - gi\|67537870\|ref\|XP_662709.1\| hypothetical protein AN5105.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	0.0	[5..748]	[9..736]
gi\|15011522 - gi\|15011522\|gb\|AAK77607.1\|AF396953_1 protein O-mannosyl transferase [Aspergillus awamori]	0.0	[4..748]	[7..737]
gi\|73964337 - gi\|73964337\|ref\|XP_537521.2\| PREDICTED: similar to Protein O-mannosyl-transferase 2 (Dolichyl-phosph...	0.0	[1..750]	[71..820]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPATGGGLA ESELRPRRGR CGPQAARAAG RDVAAEAVAR SPKRPAWGSR RFEAVGWWAL  60
   61 LALVTLLSFA TRFHRLDEPP HICWDETHFG KMGSYYINRT FFFD

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [105-333]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHPPLGKMLI GLAGYLSGYD GTFLFQKPGD KYEHHSYMGM RGFCAFLGSW LVPFAYLTVL  60
   61 DLSKSLSAAL LTAALLTFDT GCLTLSQYIL LDPILMFFIM AAMLSMVKYN SCADRPFSAP 120
  121 WWFWLSLTGV SLAGALGVKF VGLFIILQVG LNTIADLWYL FGDLSLSLVT VGKHLTARVL 180
  181 CLIVLPLALY TATFAVHFMV LSKSGPGDGF FSSAFQARLS GNNLHNASI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [334-523]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEHLAYGSVI TVKNLRMAIG YLHSHRHLYP EGIGARQQQV TTYLHKDYNN LWIIKKHNTN  60
   61 SDPLDPSFPV EFVRHGDIIR LEHKETSRNL HSHYHEAPMT RKHYQVTGYG INGTGDSNDF 120
  121 WRIEVVNRKF GNRIKVLRSR IRFIHLVTGC VLGSSGKVLP KWGWEQLEVT CTPYLKETLN 180
  181 SIWNVEDHIN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.0
Match:	1t9fA
Description:	Structural genomics of Caenorhabditis elegans: Structure of a protein with unknown function
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dolichyl-phosphate-mannose-protein mannosyltransferase activity	7.33543412640964	bayes_pls_golite062009
mannosyltransferase activity	6.32966341675541	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	2.60661923349025	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.57555885876017	bayes_pls_golite062009
receptor activity	1.99332745476324	bayes_pls_golite062009
binding	1.86366637427031	bayes_pls_golite062009
molecular transducer activity	1.71523634580131	bayes_pls_golite062009
signal transducer activity	1.71523634580131	bayes_pls_golite062009
cation channel activity	1.66500687404195	bayes_pls_golite062009
ion channel activity	1.61859406934521	bayes_pls_golite062009
substrate-specific channel activity	1.57127083095499	bayes_pls_golite062009
passive transmembrane transporter activity	1.55374970486978	bayes_pls_golite062009
channel activity	1.55374970486978	bayes_pls_golite062009
inositol-1,4,5-trisphosphate receptor activity	1.28298370923705	bayes_pls_golite062009
transferase activity	0.981084601370981	bayes_pls_golite062009
calcium channel activity	0.85901349040585	bayes_pls_golite062009
catalytic activity	0.659936859803906	bayes_pls_golite062009
calcium-release channel activity	0.65133561512386	bayes_pls_golite062009
gated channel activity	0.53737429019655	bayes_pls_golite062009
ligand-gated ion channel activity	0.52162184692236	bayes_pls_golite062009
ligand-gated channel activity	0.52162184692236	bayes_pls_golite062009
protein binding	0.405144403982597	bayes_pls_golite062009
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	0.152598505509111	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [524-628]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKLPNISLDV LQPSFPEILL ESHMVMIRGN SGLKPKDNEF TSKPWHWPIN YQGLRFSGVN  60
   61 DTDFRVYLLG NPVVWWLNLL SIALYLLSGS IIAVAMQRGA RLPAE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [629-750]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAGLSQVLLR GGGQVLLGWT LHYFPFFLMG RVLYFHHYFP AMLFSSMLTG ILWDTLLRLC  60
   61 AWGLASWPLA RGIHVAGILS LLLGTAYSFY LFHPLAYGMV GPLAQDPQSP MAGLRWLDSW 120
  121 DF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: